Abstract: The invention provides an apparatus which includes a syringe cartridge (10) having its open lower portion closed by a plunger piston (14). The upper portion is closed by a syringe cartridge closure (15) having a leur tip cap (50). Structure is optionally provided interiorly of the tip cap to retain a hollow needle (40), which is held in position by a leur tip (34), the latter being vented and provided with a seal for the needle. A displacement dome (38) is provided at the lower portion of the syringe cartridge closure (15) to displace a minor amount of fluid upon closure to seal the cartridge, and insure zero head space. The piston plunger (14) at the lower portion of the cartridge can be advanced, desirably by a second plunger (61), to empty the contents. Upon resealing, the leur tip cap (50) is applied over the leur tip (34) after a bead is formed on the tip.

Abstract: Disclosed is a method for filling a cartridge which can be subsequently capped and closed. This is done by filling to a discrete level and then applying a closure. A displacement dome is provided at the lower portion of the syringe cartridge closure to first displace a predetermined amount of air or gas and then to displace a minor amount of fluid upon closure to seal the cartridge, and insure zero head space. The entirety of the process of filling is done in a vented environment, and the closure applied at ambient. The invention also provides an apparatus which includes a syringe cartridge having its open lower portion closed by a plunger piston. The upper portion is closed by a syringe cartridge closure having a leur tip cap. Means are optionally provided interiorly of the tip cap to retain a hollow needle, which is held in position by a leur tip, the latter being vented and provided with a seal for the needle.