Patents by Inventor Rayka Yokoo

Rayka Yokoo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Variant RNA-guided polypeptides and methods of use
    Patent number: 11180778
    Abstract: The present disclosure provides (i) RNA-guided polypeptides (e.g., circular permuted Cas9 proteins) in which the N-terminal end of an N-terminal fragment of a parent RNA-guided polypeptide (e.g., a parent Cas9 protein) is fused (e.g., via linker) to the C-terminal end of the C-terminal fragment (thereby generating new N- and C-termini), (ii) conditionally active RNA-guided polypeptides (e.g., conditionally active circular permuted Cas9 proteins), and (iiii) Cas9 fusion polypeptides that include an internal insertion of a heterologous polypeptide; as well as methods that employ the above polypeptides.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: November 23, 2021
    Assignee: The Regents of the University of California
    Inventors: David Frank Savage, Jennifer A. Doudna, Benjamin L. Oakes, Rayka Yokoo
  • VARIANT RNA-GUIDED POLYPEPTIDES AND METHODS OF USE
    Publication number: 20190233847
    Abstract: The present disclosure provides (i) RNA-guided polypeptides (e.g., circular permuted Cas9 proteins) in which the N-terminal end of an N-terminal fragment of a parent RNA-guided polypeptide (e.g., a parent Cas9 protein) is fused (e.g., via linker) to the C-terminal end of the C-terminal fragment (thereby generating new N- and C-termini), (ii) conditionally active RNA-guided polypeptides (e.g., conditionally active circular permuted Cas9 proteins), and (iiii) Cas9 fusion polypeptides that include an internal insertion of a heterologous polypeptide; as well as methods that employ the above polypeptides.
    Type: Application
    Filed: November 9, 2017
    Publication date: August 1, 2019
    Inventors: David Frank Savage, Jennifer A. Doudna, Benjamin L. Oakes, Rayka Yokoo