Abstract: Provided herein is a computer program product comprising a non-transitory computer-readable medium storing an algorithm to optimize a wavefront guided correction for a custom ophthalmic lens. The correction is determined from inputs of quantified wavefront error and registration uncertainty and a metric predictive of a visual performance task of interest and provides a level of visual performance within a user-defined performance range. Also provided is a method for optimizing a wavefront guided correction for a custom ophthalmic lens via inputting residual wavefront error values and quantified translational and rotational movements into an algorithm configured to determine the optimal wavefront guided correction therefrom and a custom ophthalmic lens comprising the correction.

Abstract: Provided herein are methods of manufacturing an optical lens using image simulation and/or predictive metrics to determine optical aberrations and an iterative algorithm to correct the aberrations to create a custom-designed surface for the optical lens and to implement the manufacture of the custom-designed surface onto the lens. Also, a computer program product storing the method is provided. In addition, there are provided a customized optical lens designed by the method and a method of correcting optical aberration to improve visual using the customized optical lens. Further provided is a method of manufacturing a custom lens effective to mimic a subset of optical aberrations.

Abstract: Provided herein is a computer program product comprising a non-transitory computer-readable medium storing an algorithm to optimize a wavefront guided correction for a custom ophthalmic lens. The correction is determined from inputs of quantified wavefront error and registration uncertainty and a metric predictive of a visual performance task of interest and provides a level of visual performance within a user-defined performance range. Also provided is a method for optimizing a wavefront guided correction for a custom ophthalmic lens via inputting residual wavefront error values and quantified translational and rotational movements into an algorithm configured to determine the optimal wavefront guided correction therefrom and a custom ophthalmic lens comprising the correction.

Abstract: Provided herein are methods of manufacturing an optical lens using image simulation and/or predictive metrics to determine optical aberrations and an iterative algorithm to correct the aberrations to create a custom-designed surface for the optical lens and to implement the manufacture of the custom-designed surface onto the lens. Also, a computer program product storing the method is provided. In addition, there are provided a customized optical lens designed by the method and a method of correcting optical aberration to improve visual using the customized optical lens. Further provided is a method of manufacturing a custom lens effective to mimic a subset of optical aberrations.

Abstract: An method and system for determining the appropriate refractive prescription in a clinical optometry or opthalmology setting. Data in the form of aberrometric input, patient history and other information, and/or other environmental data is used to optimize a real-world prescription for an individual's optic needs through the use of a equivalent quadratic fitting calculation or a simulated through focus experiment.

Abstract: Several metrics to predict the subjective impact of the eye's wavefront aberrations are presented. The metrics can be based on RMS wavefront errors or slopes, the area of the critical pupil, a curvature parameter, the point spread function, the optical transfer function, or the like. Other techniques include the fitting of a sphero-cylindrical surface, the use of multivariate metrics, and customization of the metric for patient characteristics such as age.

Abstract: A method for classifying a patient's eye includes the steps of: obtaining normal and abnormal wavefront aberration data from normal and abnormal eyes; fitting the normal and abnormal eye wavefront aberration data with a basis function to decompose the normal and abnormal eye wavefront aberration data into normal and abnormal eye mathematical components; examining the normal and abnormal eye mathematical components to develop mathematical optical filters capable of discriminating between normal and abnormal eyes, using statistical methods to define a probability distribution; obtaining wavefront aberration data from the patient's eye; fitting the patient's wavefront aberration data with a basis function to decompose the patient's wavefront aberration data into the patient's set of mathematical components; examining the patient's set of mathematical components using the mathematical optical filters to generate a patient filter value; and classifying the patient's eye by comparing the patient filter value wit

Abstract: A method for classifying a patient's eye includes the steps of: obtaining normal and abnormal wavefront aberration data from normal and abnormal eyes; fitting the normal and abnormal eye wavefront aberration data with a basis function to decompose the normal and abnormal eye wavefront aberration data into normal and abnormal eye mathematical components; examining the normal and abnormal eye mathematical components to develop mathematical optical filters capable of discriminating between normal and abnormal eyes, using statistical methods to define a probability distribution; obtaining wavefront aberration data from the patient's eye; fitting the patient's wavefront aberration data with a basis function to decompose the patient's wavefront aberration data into the patient's set of mathematical components; examining the patient's set of mathematical components using the mathematical optical filters to generate a patient filter value; and classifying the patient's eye by comparing the patient filter value with t

Abstract: Methods, systems, and media relating the display of scattering and/or absorption characteristics of an optical medium. For scattering measurements, a Hartmann-Shack calibration image of a measurement system is acquired to define a first plurality of point spread functions. A Hartmann-Shack test image of the medium is acquired to define a second plurality of point spread functions. A shift is determined between the test image and the calibration image. A point spread of each of the second plurality of point spread functions is measured, each of the second plurality of point spread functions including a component due to optical aberration of the medium and a component due to scatter. The component due to optical aberration is determined using the shift. The component due to optical aberration is deconvolved to determine the component due to scatter. A display of the local scattering characteristics is generated using the component due to scatter.

Abstract: Several metrics to predict the subjective impact of the eye's wavefront aberrations are presented. The metrics can be based on RMS wavefront errors or slopes, the area of the critical pupil, a curvature parameter, the point spread function, the optical transfer function, or the like. Other techniques include the fitting of a sphero-cylindrical surface, the use of multivariate metrics, and customization of the metric for patient characteristics such as age.

Abstract: Methods, systems, and media relating the display of scattering and/or absorption characteristics of an optical medium. For scattering measurements, a Hartmann-Shack calibration image of a measurement system is acquired to define a first plurality of point spread functions. A Hartmann-Shack test image of the medium is acquired to define a second plurality of point spread functions. A shift is determined between the test image and the calibration image. A point spread of each of the second plurality of point spread functions is measured, each of the second plurality of point spread functions including a component due to optical aberration of the medium and a component due to scatter. The component due to optical aberration is determined using the shift. The component due to optical aberration is deconvolved to determine the component due to scatter. A display of the local scattering characteristics is generated using the component due to scatter.

Abstract: Methods, systems, and media relating the display of scattering and/or absorption characteristics of an optical medium. For scattering measurements, a Hartmann-Shack calibration image of a measurement system is acquired to define a first plurality of point spread functions. A Hartmann-Shack test image of the medium is acquired to define a second plurality of point spread functions. A shift is determined between the test image and the calibration image. A point spread of each of the second plurality of point spread functions is measured, each of the second plurality of point spread functions including a component due to optical aberration of the medium and a component due to scatter. The component due to optical aberration is determined using the shift. The component due to optical aberration is deconvolved to determine the component due to scatter. A display of the local scattering characteristics is generated using the component due to scatter.

Abstract: Methods, systems, and media relating the display of scattering and/or absorption characteristics of an optical medium. For scattering measurements, a Hartmann-Shack calibration image of a measurement system is acquired to define a first plurality of point spread functions. A Hartmann-Shack test image of the medium is acquired to define a second plurality of point spread functions. A shift is determined between the test image and the calibration image. A point spread of each of the second plurality of point spread functions is measured, each of the second plurality of point spread functions including a component due to optical aberration of the medium and a component due to scatter. The component due to optical aberration is determined using the shift. The component due to optical aberration is deconvolved to determine the component due to scatter. A display of the local scattering characteristics is generated using the component due to scatter.

Abstract: Described herein are a range of techniques and apparatuses used to study the retinal vasculature near the fovea, a description of the need and rationale for noninvasive in vivo monitoring of the retinal vasculature, a presentation of theoretical and practical considerations which demonstrate that entoptic visualization of the smallest capillaries near the fovea is optimized by a short wavelength source of light which is constrained to enter the eye through a small limiting aperture moving in space near the eye at an optimized velocity in a circular or irregular path, and a discussion of the feasibility of using these techniques in a museum or novelty device as well as a research and clinical tool.

Abstract: Described herein are an apparatus and range of techniques used to study the retinal vasculature near the fovea, a description of the need and rationale for noninvasive in vivo monitoring of the retinal vasculature, a presentation of theoretical and practical considerations which demonstrate that entoptic visualization of the smallest capillaries near the fovea is optimized by a small short wavelength source (1 mm or less) rotating at 3.5 Hz in a circular path (radius 2 mm) imaged in the plane of the eye's entrance pupil and a discussion of the feasibility of using these techniques as a reseResearch relating to the development of the present invention was supported in part by grants from the United States Department of Health and Human Services (NIH EY08005 and EY07638). The United States government may have corresponding rights to the license and use of any resulting patent.

Abstract: A biomedical "tab" type of electrode suited for use with male and female connectors of the type that are adapted to snap together is provided. The female connector is located at one end of a lead wire. A male snap connector is secured to the lead wire by means of a flexible tether. The electrode includes an extension or tab having an opening therein. The tether is mounted on the lead wire and is preferably adapted to slide along its length. During use, the male snap connector can be moved into proximity of the female connector and aligned with it on opposite sides of the tab portion of the electrode and then brought into contact and connected to each other through the opening in the tab to establish both a mechanical and an electrical connection with the tab of the electrode.