Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: A connection to releasably connect and disconnect to a pipe to a fitting provides a pipe fitting body for receiving a pipe and a retaining ring located within the fitting body for retaining and releasing the pipe. The retaining ring has axially extending resilient retaining tabs, each of which has a radially inwardly extending portion for engaging the pipe, and, a radially outwardly extending portion which extends through corresponding radial openings in the fitting body. When the pipe is inserted into the fitting body to an inserted position and the retaining ring is in the first locked axial position, the radially inwardly extending portions engage and retain the pipe in the inserted position.

Abstract: A luminaire can include a power supply that receives AC mains power from a power source and delivers intermediate power. The luminaire can also include a control module coupled to the power supply, wherein the control module receives the intermediate power from the power source, where the control module includes at least one first switch that has multiple positions, where each position of the at least one first switch corresponds to an output power level of a plurality of output power levels. The output power level can correspond to a discrete photometric distribution by a plurality of light sources of the luminaire.

Abstract: A foldable rectangular plastic/composite enclosure having first, second, third and fourth sides connected by hinges. The enclosure folds flat by rotating the sides on the hinges but is constructed to fold only in one direction. The hinges allow the enclosure to be folded flat for storage and transportation. The hinges are composed of a plurality of hinge members wherein each hinge member is positioned in a housing. The housing has an open interior which helps anchor the enclosure in the ground. An insertable locking pin can be inserted through each hinge to prevent the enclosure from folding. The enclosure can be made of plastic/composite imbedded with fibers such as carbon fibers, glass fibers, or ceramic fibers or imbedded with particles such as glass particles. The use of plastic/composite and various openings or cutouts makes the enclosure light weight.

Abstract: A surge monitoring circuit for detecting transient spikes in an input voltage includes a voltage divider circuit that generates a divider output voltage from the input voltage, a reference voltage generator circuit that generates reference voltages, and a comparator circuit that generates comparator signals by comparing the divider output voltage to the reference voltages. The surge monitoring circuit further includes a processor configured to predict, at least based on the comparator signals, an expected failure of a surge suppressor circuit that suppresses the transient spikes, where the comparator signals indicate detections of divider output transient spikes in the divider output voltage. The divider output transient spikes correspond to transient spikes in the input voltage, where the divider output transient spikes have a higher voltage than the one or more reference voltages.

Abstract: A copolymer includes a hydrophobic head segment and a random copolymer tail segment comprising hydrophobic blocks and ionizable blocks. Emulsion polymerization systems incorporate the copolymer as a surfactant.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: A lighting device includes a first string of light emitting diodes (LEDs) configured to emit a warm white light having a warm Correlated Color Temperature (CCT). The lighting device further includes a second string of LEDs configured to emit a cool white light having a cool CCT. The lighting device also includes green light LEDs that emit a green light. A flux of the green light is controlled based on a flux of the cool white light or a flux of the warm white light. The flux of the warm white light and the flux of the cool white light change proportionally with respect to each other.

Abstract: A connection to releasably connect and disconnect to a pipe to a fitting provides a pipe fitting body for receiving a pipe and a retaining ring located within the fitting body for retaining and releasing the pipe. The retaining ring has axially extending resilient retaining tabs, each of which has a radially inwardly extending portion for engaging the pipe, and, a radially outwardly extending portion which extends through corresponding radial openings in the fitting body. When the pipe is inserted into the fitting body to an inserted position and the retaining ring is in the first locked axial position, the radially inwardly extending portions engage and retain the pipe in the inserted position.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: An electrical device can include a sensor module that measures at least one parameter, where the at least one parameter is associated with determining the presence of a living being in a volume of space. The electrical device can also include a controller coupled to the sensor module, where the controller receives a measurement of the at least one parameter to determine whether the living being is in the volume of space. The electrical device can further include at least one ultraviolet (UV) light source coupled to the controller, which operates the at least one UV light source to emit UV light when the living being is not in the volume of space, and where the controller prevents the at least one UV light source from emitting the UV light when the living being is in the volume of space.

Abstract: A method for producing a scaled-up solid model of microscopic features of a selected surface. A selected surface on a piece of metal exposed to friction, for example, is scanned with a profilometer along X, Y, and Z coordinates to obtain measurements of surface features. A 3-D high resolution spatial map of the surface features is made and the X, Y, and Z measurements are scaled up as desired. The spatial map is transposed into a high resolution 3-D scaled-up meshed surface. A data set of printing instructions is made from the 3-D scaled-up meshed surface acceptable for use in a 3-D printer. A solid scaled-up model of the selected surface is manufactured in the 3-D printer in any desired size using the printing instructions. The method provides a physical hand-held model of the selected surface that can be used to demonstrate accurately the effectiveness of lubrication and anti-friction products, both visually and by touch.

Abstract: A blender assembly including a blender vessel and a blender hub. The blender hub having a plurality of first guide elements. The blender vessel having a rim, the blender vessel further having a plurality of second guide elements that each cooperate with a respective one of the first guide elements for forming a coupled and a sealed engagement to the blender hub. By releasing the coupling, the first and second guide elements cooperate to provide a two-stage release. A first stage of the release breaking the sealed engagement, and maintaining a loose coupled engagement, between the blender hub and the bender vessel. A second stage of the release, subsequent to the first stage of the release, releasing the coupled engagement between the blender hub and the blender vessel.

Abstract: Disclosed is a utility pole formed as a hollow tube having a pentagonal exterior surface with the junctions of the sides of the pentagon each forming a dove tail channel. An interior surface of the hollow tube is round to allow insertion of round reinforcing sleeves. A mounting member is configured for attachment to the dove tail channel on an exterior of the hollow tube by means of a cam fastener system in an interior of the mounting block. The cam fastener system has a plurality of cams mounted rotatably on a pair of hinges, configured to allow the cam fastener system to open and close in an interior of the dove tail channel. The cam fastener system can be directly inserted into or removed from a dove tail channel anywhere along the length of the dove tail channel by closing it. The cam fastener system fastens the mounting member to the dove tail channel by opening the cam fastener system when it is in the interior of the dove tail channel.

Abstract: A lighting fixture includes a voltage source circuit and a first light module comprising a first current source circuit and a first light emitting diode (LED) light source. The lighting fixture further includes a second light module that includes a second current source circuit and a second LED light source. The voltage source circuit is configured to provide a voltage source output voltage to the first current source circuit and to the second current source circuit. The first current source circuit is configured to provide a first current to the first LED light source. The second current source circuit is configured to provide a second current to the second LED light source. A voltage level of the voltage source output voltage depends on a waveform of a line dimmer output voltage that is provided to the voltage source circuit.

Abstract: A luminaire can include a power supply that receives AC mains power from a power source and delivers intermediate power. The luminaire can also include a control module coupled to the power supply, wherein the control module receives the intermediate power from the power source, where the control module includes at least one first switch that has multiple positions, where each position of the at least one first switch corresponds to an output power level of a plurality of output power levels. The output power level can correspond to a discrete photometric distribution by a plurality of light sources of the luminaire.

Abstract: A lighting device includes a first string of light emitting diodes (LEDs) configured to emit a warm white light having a warm Correlated Color Temperature (CCT). The lighting device further includes a second string of LEDs configured to emit a cool white light having a cool CCT. The lighting device also includes green light LEDs that emit a green light. A flux of the green light is controlled based on a flux of the cool white light or a flux of the warm white light. The flux of the warm white light and the flux of the cool white light change proportionally with respect to each other.

Abstract: A lighting fixture includes a voltage source circuit and a first light module comprising a first current source circuit and a first light emitting diode (LED) light source. The lighting fixture further includes a second light module that includes a second current source circuit and a second LED light source. The voltage source circuit is configured to provide a voltage source output voltage to the first current source circuit and to the second current source circuit. The first current source circuit is configured to provide a first current to the first LED light source. The second current source circuit is configured to provide a second current to the second LED light source. A voltage level of the voltage source output voltage depends on a waveform of a line dimmer output voltage that is provided to the voltage source circuit.

Abstract: A lighting device includes a light source that emits an illumination light. The light source includes a first group of light emitting diodes (LEDs) to emit a first light, a second group of LEDs to emit a second light, and a third group of LEDs to emit a third light. The second light is warmer light than the first light, and the third light is cooler light than the first light. The lighting device further includes a first difference amplifier that controls a first current flow through the second group of LEDs at least based on a magnitude of a current flowing through the light source. The lighting device also includes a second difference amplifier that controls a second current flow through the third group of LEDs at least based on the magnitude of the current flowing through the light source.