Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: This application relates to a system, method, and non-transitory computer readable medium for implementing a queuing platform. In some embodiments, a user request is received and it determined whether the user request matches predetermined criteria. Embodiments can include assigning the user request to an item queue and issuing a ticket. In further embodiments, the ticket is validated and an access token is transmitted to the user device based on the validation of the ticket. A checkout request corresponding to the at least one user request is received and validated. In some embodiments, the user request is transmitted from the item queue to a checkout engine to complete a purchase of the item based on the validation of the access token received in the checkout request.

Abstract: A method for detecting data drift between a first database and a second database involves obtaining (from the first database) and based on a change data capture (CDC) event generated in response to a change detected in the first database, a first record identified by the CDC event, obtaining (from the second database) a second record corresponding to the first record, transforming a data structure of the first record from the first database to the data structure of the second database generating a transformed record, and based on determining that a difference between the first record and a second record exists, reporting a presence of data drift.

Abstract: The present disclosure includes computer implemented techniques for providing a survey to a user. In one embodiment, a software application receives an audio stream including utterances spoken by the user interacting with a voice-user interface of the application. The application then determines a set of paralinguistic features from the audio stream and estimates at least a first attribute of the user based on the set of paralinguistic features. The application selects survey content based on a value of the first attribute and transmits a survey including the selected survey content to the user.

Abstract: A method may include selecting a cohort of entities for migration from a source storage repository to a target storage repository, obtaining a mapping between a source storage schema of the source storage repository to a target storage schema of the target storage repository, and migrating data for the entities in the cohort. Migrating the data of an entity may include copying, without locking the data in the source storage repository and in the target storage repository, the data from the source storage repository to the target storage repository, verifying, while the data is locked, that the data in the source storage repository is the same as the data in the target storage repository, changing, while the data in the source storage repository and the target storage repository is locked, an entity pointer for the entity to the target storage repository based on the verifying, and unlocking the data.

Abstract: Embodiments disclosed herein select a content message to present to a user on a page of an application based on paralinguistic features of audio input received from the user for the application. The audio input is received via a microphone associated with a computing device. A feature extractor extracts paralinguistic features from the audio input. A predictive model determines a label indicating a measure of receptiveness to product placement (e.g., a predicted marketing outcome) based on the paralinguistic features. A content-selection component selects a content message to present to the user based on the label and based on a profile of the user.

Abstract: A system, device and method include a sensing enabled device having an optical fiber configured to perform distributed sensing of temperature-induced strain. An interpretation module is configured to receive optical signals from the optical fiber within a body and interpret the optical signals to determine one or more temperature transition points sensed by the sensing enabled device for image registration.

Abstract: An optical guidewire system employs an optical guidewire (10), an optical guidewire controller (12), a guide interface (13) and an optical connector (15). The optical guidewire (10) is for advancing a catheter (20) to a target region relative to a distal end of the optical guidewire (10), wherein the optical guidewire (10) includes one or more guidewire fiber cores (11) for generating an encoded optical signal (16) indicative of a shape of the optical guidewire (10). The optical guidewire controller (12) is responsive to the encoded optical signal (16) for reconstructing the shape of the optical guidewire (10). The guidewire interface (13) includes one or more interface fiber core(s) (14) optically coupled to the optical guidewire controller (12). The optical connector (15) facilitates a connection, disconnection and reconnection of the optical guidewire (10) to the guidewire interface (13) that enables a backloading the catheter (20) on the optical guidewire (10).

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

Abstract: A medical system for minimally-invasive measurement of blood flow in an artery (AT). An interventional device (IVD) with an optical fiber (FB) comprising a plurality of temperature-sensitive optical sensor segments, e.g. Fiber Bragg Gratings, spatially distributed along its longitudinal extension is configured for insertion into an artery (AT). A temperature changer (TC) is arranged in the WD to introduce a local change in temperature (?T) of a bolus of blood in the artery, to allow thermal tracking over time with the optical fiber (FB). A measurement unit (MU) with a laser light source (LS) delivers light to the optical fiber (FB) and receives light reflected from the optical fiber (FB) and generates a corresponding time varying output signal. A first algorithm (A1) translates this time varying output signal into a set of temperatures corresponding to temperatures at respective positions along the optical fiber (FB).

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

Abstract: Embodiments disclosed herein select a content message to present to a user on a page of an application based on paralinguistic features of audio input received from the user for the application. The audio input is received via a microphone associated with a computing device. A feature extractor extracts paralinguistic features from the audio input. A predictive model determines a label indicating a measure of receptiveness to product placement (e.g., a predicted marketing outcome) based on the paralinguistic features. A content-selection component selects a content message to present to the user based on the label and based on a profile of the user.

Abstract: A method for end-reflection reduction of an optical shape-sensing fiber is described. The includes: providing a tip portion having a length dimension (d); connecting the tip portion to an end portion of an optical fiber configured for optical shape-sensing, the tip portion being indexed matched to the optical fiber; and adjusting the absorption properties of the tip portion using back reflections as feedback to provide an absorption length for light traveling in the optical fiber to reduce the back reflections.

Abstract: A reflection reduction device includes an optical fiber (104) configured for optical sensing and having an end portion. A tip portion (102) is coupled to the end portion. The tip portion includes a length dimension (d) and is index matched to the optical fiber. The tip portion is further configured to include an absorption length to absorb and scatter light within the length dimension, and a surface (S) opposite the end portion is configured to reduce back reflections.

Abstract: A medical method and system include a medical imaging system configured to generate images of an interventional procedure. An overlay generator is configured to generate an overlay image on the images of the interventional procedure. An interventional device tracking system is configured to track a three-dimensional position, orientation and shape of the interventional device during the procedure, wherein the overlay image is dynamically updated in response to deformations caused to an organ of interest by the interventional device during the procedure.

Abstract: Embodiments disclosed herein select a content message to present to a user on a page of an application based on paralinguistic features of audio input received from the user for the application. The audio input is received via a microphone associated with a computing device. A feature extractor extracts paralinguistic features from the audio input. A predictive model determines a label indicating a measure of receptiveness to product placement (e.g., a predicted marketing outcome) based on the paralinguistic features. A content-selection component selects a content message to present to the user based on the label and based on a profile of the user.

Abstract: Systems and methods for locating a medical device in a body lumen are provided. A first flexible elongate instrument comprises a plurality of imaging markers, and a location information sensor is disposed at the first flexible elongate instrument or at a second flexible elongate instrument configured for relative movement with respect to the first flexible elongate instrument. A processor is configured to establish a reference coordinate system based on the plurality of imaging markers, which are visible in a medical image comprising the first flexible elongate instrument disposed in a body lumen, receive diagnostic scan or therapeutic delivery information at a plurality of locations of the body lumen from the first or second flexible elongate instrument, and correlate the information with the imaging markers. A display configured to display a composite image comprising the correlated diagnostic scan or therapeutic delivery information and the imaging markers.

Abstract: Certain aspects of the present disclosure provide techniques for selecting a response to a self-support query. One example method generally includes receiving an audio stream query including spoken content from a user recorded by a mobile device and determining a set of paralinguistic features from the spoken content. The method further includes estimating an emotional state of the user based on the set of paralinguistic features and identifying subject matter of the spoken content in the audio stream query. The method further includes determining two or more query responses corresponding to the subject matter to present to the user and transmitting at least one query response to the mobile device.

Abstract: A guidance system and method include a real-time imaging device (121) configured to intra-operatively collect image data of a target region to provide a real-time image. A target determination module (108) is configured to generate an overlay map (111) registered to the real-time image to project morphological feature information on corresponding features in the real-time image of the target region. A medical instrument (122) is provided to perform a procedure on the target region such that the at least one medical instrument is guided to a region suitable for performing an operative task based upon the overlay map.

Abstract: An apparatus, system and method for determining a position of an instrument (100) includes a sheath (104) configured to fit within an instrument channel of a medical scope. An optical fiber (112) is disposed within the sheath and a plurality of sensors (106) is integrated in optical fiber. The sensors are configured to measure deflections and bending in the optical fiber. A fixing mechanism (140) is sized to fit within the instrument channel in a first state and fixes the sheath within the instrument channel in a second state such that the fixing mechanism anchors the sheath and the optical fiber so that the deflections and bending in the optical fiber are employed with a pre-procedural volumetric image to determine a position of the instrument.