Abstract: The present invention provides a non-mediative approach to capture biological cells and initiate cell pairing and fusion in a microfluidic-based system with multiple channels configured in various dimensions and shapes in order to create a hydrodynamic platform incorporating a passive trapping mechanism to entrap the cells of interest from fluid flowing through the multiple channels and allow cell fusion with certain rheological deformation in the absence of any cell disruption while the whole cell pairing and fusion process is closely monitored by simple optical monitoring device.

Abstract: A sample plate for a microscope comprising an optically transparent substrate comprising first and second faces; the first face comprising a recess wall defining a concave recess for receiving a microscope sample; and, a lens extending from the second face, the lens being defined by a lens face; the lens being arranged opposite the recess.

Abstract: The present disclosure relates to systems and methods for quantifying mechanical properties of a cell containing a nucleus and cytoplasm. The system comprises a microfluidic comprises a varying width configured to deform the cell to multiple deformation levels, an imaging device configured to obtain image data of the cell received by the microfluidic channel and a processor in communication with the imaging device. The processor is configured to receive, from the imaging device, image data of the cell deformed within the microfluidic channel at a first deformation level and a second deformation level different from the first deformation level and to determine, based on the image data, one or more parameters associated with the deformed cell at the first deformation level and the second deformation level.

Abstract: There is provided an apparatus for detection of electrical signals of a biological subject. The apparatus comprises an electrode acting as a conductor for contact with skin of the subject. The electrode includes a first sheet material acting as a base layer and a plurality of pillars members extending from the first sheet material. The apparatus is free of gel or wet gel acting as an electrical conductive media.

Abstract: There is provided an apparatus for detection of electrical signals of a biological subject. The apparatus comprises an electrode acting as a conductor for contact with skin of the subject. The electrode includes a first sheet material acting as a base layer and a plurality of pillars members extending from the first sheet material. The apparatus is free of gel or wet gel acting as an electrical conductive media.