Patents by Inventor Raymond J. A. Budde

Raymond J. A. Budde has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thienopyrimidine-based inhibitors of the src family
    Patent number: 7285556
    Abstract: Various thienopyrimidine-based analog compounds are able to selectively inhibit the Src family of tyrosine kinases. Compounds of the present invention, capable of such selective inhibition, are of the basic structure seen in formulae (I), (II) or (III): These compounds are useful in the treatment of a wide variety of diseases including hyperproliferative diseases, hematologic allergic/immunological diseases, or viral infections. Methods of synthesis of these compounds and their methods of inhibiting the Src family of tyrosine kinases are presented.
    Type: Grant
    Filed: October 23, 2001
    Date of Patent: October 23, 2007
    Assignee: Board of Regents, The University of Texas Systems
    Inventors: Michele A. Benish, Michael Lawless, Raymond J. Budde
  • Thienopyrimidine-based inhibitors of the src family
    Publication number: 20040077663
    Abstract: Various thienopyrimidine-based analog compounds are able to selectively inhibit the Src family of tyrosine kinases. These compounds are useful in the treatment of various diseases including hyperproliferative diseases, hematologic diseases, osteoporosis, neurological diseases, autoimmune diseases, allergic/immunological diseases, or viral infections.
    Type: Application
    Filed: October 6, 2003
    Publication date: April 22, 2004
    Inventors: Michele A. Benish, Michael Lawless, Raymond J. Budde
  • Thienopyrimidine-based inhibitors of the Src family
    Patent number: 6503914
    Abstract: Various thienopyrimidine-based analog compounds that selectively inhibit the Src family of tyrosine kinases. These compounds are thienopyrimidines and contain a hydrozone bridge created by heating a thienopyrimidine hydrazine with an aldehyde in ethanol at reflux. Such compounds are useful in the treatment of various diseases including hyperproliferative diseases, hematologic diseases, osteoporosis, neurological diseases, autoimmune diseases, allergic/immunological diseases, or viral infections.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: January 7, 2003
    Assignee: Board of Regents, The University of Texas System
    Inventors: Michele A. Benish, Michael Lawless, Raymond J. A. Budde
  • Inhibitors of protein tyrosine kinases
    Patent number: 6100254
    Abstract: Disclosed herein are small molecule, non-peptidyl inhibitors of protein tyrosine kinases, and methods for their use. The instant inhibitors are based on a 1,4-benzodiazepin-2-one nucleus. Methods are provided for inhibition of specific protein tyrosine kinases, for example pp60.sup.c-src. Methods are further provided for the use of these inhibitors in situations where the inhibition of a protein tyrosine kinase is indicated, for example, in the treatment of certain diseases in mammals, including humans.
    Type: Grant
    Filed: October 10, 1997
    Date of Patent: August 8, 2000
    Assignees: Board of Regents, The University of Texas System, The Regents of the University of California
    Inventors: Raymond J. A. Budde, Jonathan A. Ellman, Victor A. Levin, Gary E. Gallick, Robert A. Newman
  • Thienopyrimidine-based inhibitors of the SRC family
    Patent number: RE39267
    Abstract: Various thienopyrimidine-based analog compounds that selectively inhibit the Src family of tyrosine kinases. These compounds are thienopyrimidines and contain a hydrozone bridge created by heating a thienopyrimidine hydrazine with an aldehyde in ethanol at reflux. Such compounds are useful in the treatment of various diseases including hyperproliferative diseases, hematologic diseases, osteoporosis, neurological diseases, autoimmune diseases, allergic/immunological diseases, or viral infections.
    Type: Grant
    Filed: June 28, 2004
    Date of Patent: September 5, 2006
    Assignee: Board of Regents, The University of Texas System
    Inventors: Michele A. Benish, Michael Lawless, Raymond J. A. Budde