Patents by Inventor Raymond J. Hohl

Raymond J. Hohl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods to modulate Rac1 import and to treat pulmonary fibrosis
    Patent number: 9416149
    Abstract: The invention provides methods for treating fibrosis, as well as methods for modulating mitochondrial peroxide production in a cell, and methods for modulating the import of Rac1 into the mitochondria of a cell.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: August 16, 2016
    Assignee: University of Iowa Research Foundation
    Inventors: Raymond J. Hohl, A. Brent Carter
  • METHODS TO MODULATE RAC1 IMPORT AND TO TREAT PULMONARY FIBROSIS
    Publication number: 20150005261
    Abstract: The invention provides methods for treating fibrosis, as well as methods for modulating mitochondrial peroxide production in a cell, and methods for modulating the import of Rac1 into the mitochondria of a cell.
    Type: Application
    Filed: April 25, 2014
    Publication date: January 1, 2015
    Applicant: University of Iowa Research Foundation
    Inventors: Raymond J. Hohl, A. Brent Carter
  • Schweinfurthin analogues
    Patent number: 8637685
    Abstract: The invention provides fluorescent schweinfurthin analogs of formula (I) which are useful as probes and for the treatment of cancer and other diseases.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: January 28, 2014
    Assignee: University of Iowa Research Foundation
    Inventors: David F. Wiemer, Jeffrey D. Neighbors, Raymond J. Hohl, Craig Kuder
  • SCHWEINFURTHIN ANALOGUES
    Publication number: 20110160297
    Abstract: The invention provides fluorescent schweinfurthin analogs of formula(I) which are useful as probes and for the treatment of cancer and other diseases.
    Type: Application
    Filed: June 25, 2009
    Publication date: June 30, 2011
    Applicant: University of Iowa Research Foundation
    Inventors: David F. Wiemer, Jeffrey D. Neighbors, Raymond J. Hohl, Craig Kuder
  • Prenylated Bisphosphonates as Anti-tuberculosis Agents
    Publication number: 20100240612
    Abstract: The invention provides methods to treat a mycobacterium infection and methods to inhibit mycobacterial polyprenyl pyrophosphate synthesis with a compound of formula I. The invention also provides novel compounds of formula I as well as salts and prodrugs thereof.
    Type: Application
    Filed: March 22, 2010
    Publication date: September 23, 2010
    Applicant: University of Iowa Research Foundation
    Inventors: David F. Wiemer, Rocky J. Barney, Raymond J. Hohl
  • Geranylgeranyl pyrophosphate synthase inhibitors
    Patent number: 7268124
    Abstract: The invention provides novel pyrophosphate synthase inhibitors of formula I as well as compositions comprising such inhibitors and methods for their use.
    Type: Grant
    Filed: August 25, 2005
    Date of Patent: September 11, 2007
    Assignee: University of Iowa Research Foundation
    Inventors: David F. Wiemer, Raymond J. Hohl
  • Isoprenoid analog compounds and methods of making and use thereof
    Publication number: 20040167102
    Abstract: The invention provides compounds of formula I: 1
    Type: Application
    Filed: February 17, 2004
    Publication date: August 26, 2004
    Applicant: University of Iowa Research Foundation.
    Inventors: David Wiemer, Raymond J. Hohl
  • Isoprenoid analog compounds and methods of making and use thereof
    Patent number: 6727234
    Abstract: The invention provides compounds of formula I: wherein X, R1, R2, and n have any of the values defined in the specification, and their pharmaceutically acceptable salts. The compounds are useful, for example, for blocking prenylation transferase enzymes, for probing or diagnosing protein prenylation processes, and for treating cancer in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and intermediates useful for the synthesis of compounds of formula I.
    Type: Grant
    Filed: April 3, 2002
    Date of Patent: April 27, 2004
    Assignee: University of Iowa Research Foundation
    Inventors: David Wiemer, Raymond J. Hohl
  • Isoprenoid analog compounds and methods of making and use thereof
    Publication number: 20030022869
    Abstract: The invention provides compounds of formula I: 1
    Type: Application
    Filed: April 3, 2002
    Publication date: January 30, 2003
    Inventors: David Wiemer, Raymond J. Hohl