Abstract: Effective and economical compositions and methods are disclosed for the treatment, and prevention of diseases and disorders associated with inflammation and/or damage to the gastrointestinal tract, including environmental enteric dysfunction. Compositions are provided comprising a synergistic combination of colostrum, immune egg, and optionally one or more additional active agents.

Abstract: Compositions comprising a pancreatic secretory trypsin inhibitor (PSTI) peptide are provided herein for use in reducing hypoxia-reoxygenation-induced cell death, reducing gut ischemia-reperfusion-induced injury, and/or for use in treating or preventing damage to remote organs secondary to gut ischemia-reperfusion.

Abstract: A method for prophylactically treating irritable bowel syndrome in a mammal through the administration of a zinc carnosine composition like zinc carnosine is provided, although other forms of zinc carnosine or other components exhibiting zinc carnosine activity like other metal carnosine complexes may be used. The effective amount of composition to be used will depend upon such factors as the age and weight of the mammal, and whether treatment of existing IBS symptoms, or prevention of the onset of IBS symptoms is desired. A complex comprising such a zinc carnosine composition for prophylactically treating IBS in a mammal is also provided.

Abstract: A method of scoring the biological activity of bioactive agents like colostrum comprising conducting separate bioassays for cell restitution and cell proliferation on the bioactive agent, a comparative growth factor stimulating agent, and (preferably) a negative baseline control sample containing the cells and growth medium alone. These values are then plugged into the equations provided in this application to calculate a Restitution Score (“RS”), Proliferation Score (“PS”), and a composite repair and protection factor score (“RPF”). In this manner, the bioactivity of compositions that enhance the repair and/or proliferation of mammalian cells, or act as additives to growth media used to maintain and grow laboratory cell cultures can be quickly and reproducibly obtained. This invention may be applied to a wide variety of bioactive agents used to treat a large assortment of functional cells in organ tissues.