Abstract: The present disclosure pertains to sample preparation devices useful for affinity capture and purification that include one or more internal structures that comprise a reservoir, a well, a fluid passageway, sorbent particles, and a filter element that blocks passage of the affinity sorbent particles, which sample preparation devices combine the attributes of both dispersive and flow through designs into a single sample preparation device. The present disclosure also pertains to kits that contain and methods that use such sample preparation devices.

Abstract: The present disclosure describes systems and methods for efficient reporting of data which includes personally identifiable information (PII) and which is collected and processed by a security awareness system. The data may be stored in a data storage system. The data may include a time stamp and queries of an historical nature may be supported.

Abstract: Systems and methods comprising determining a first user in proximity to a point of sale (POS) device of a second user, the POS device having detected an identity of the first user and a number of devices associated with the POS device. The number of devices is compared to a baseline number of devices in proximity to the POS device, which is based on a time of day and calculated from a time period prior to the time of day. Based on a determination that the number differs from the baseline number by more than a threshold amount, data is generated that includes an indication configured to be displayed utilizing a client application executing on a device of the first user, wherein user interaction with the indication enables the user to at least one of initiate or modify a transaction with the second user.

Abstract: Methods and compositions comprising primers and probes to detect nucleic acids are provided. The probes comprise a ribonucleotide that can be cleaved by an RNase H2 enzyme when the probe is annealed to a reverse complement of a universal sequence that is introduced to a target nucleic acid, for example via amplification.

Abstract: A system and a method to wirelessly synchronize, monitor, or communicate, or a combination thereof, amongst sensors (e.g., sensors, hubs, sensor controllers, etc.) in a Bluetooth Low Energy-based microlocation system. The system or method, or both, may use the BLE hardware (e.g., transmitters, receivers, antennas, etc.) to interleave a communications protocol within the connection interval gaps of the BLE protocol used to communicate with devices.

Abstract: The invention relates to the use of a wetting composition comprising (a) from 20 to less than 50 wt % of one or more C10 to C14 alcohol, (b) 25 to 70 wt % of a surfactant selected from a non-ionic, cationic, anionic and amphoteric surfactant, and (c) from 5 to 50 wt % of a polar component comprising at least one selected from (i) water, and (ii) up to 25 wt % of a water-miscible C1-C3 organic solvent in lowering the surface tension of non-aqueous liquids, to methods for using the wetting composition, and products and non-aqueous compositions containing the wetting composition.

Abstract: An optical fibre assembly comprises a hollow core optical waveguide comprising a hollow core surrounded by a structured arrangement of longitudinally extending capillaries providing an inner cladding surrounded by an outer cladding; a diagnostic solid core optical waveguide comprising a solid core surrounded by a cladding, and extending substantially parallel to the hollow core optical waveguide; and a jacket surrounding both the hollow core optical waveguide and the solid core optical waveguide and forming a common mechanical environment for the hollow core optical waveguide and the solid core optical waveguide. The optical fibre assembly may be or may comprise or be included in an optical fibre cable, and may be used in a method for testing hollow core optical waveguides.

Abstract: The invention relates to the use of a wetting composition comprising a surfactant selected from a non-ionic, cationic, anionic and amphoteric surfactant in combination with from 10 to less than 50 wt % of at least one C10 to C14 alcohol and 10 to 30 wt % of a C4-C6 oxygen containing co-solvent in lowering the surface tension of non-aqueous liquids, to methods for using the wetting composition, and products including non-aqueous compositions containing the wetting composition.

Abstract: A method of extracting a substance comprising the steps of: placing a substrate on which a substance has been adsorbed into a container; feeding a solvent into the container whilst restricting its exit to achieve a predetermined pressure of the solvent in the container, wherein the solvent has a critical point and the predetermined pressure is above the critical point of the solvent; releasing the solvent and an extract comprising extracted substances into a separator; reducing the temperature and pressure in the separator to remove a gaseous portion of the solvent from the extract; collecting the extract remaining from the separator.

Abstract: In general, this disclosure describes techniques for applying a distributed pipeline model in a distributed computing system to cause processing nodes of the distributed computing system to process data according to a distributed pipeline having an execution topology, specified within a pipeline statement, to perform a task.

Abstract: An optical fibre assembly comprises a hollow core optical waveguide comprising a hollow core surrounded by a structured arrangement of longitudinally extending capillaries providing an inner cladding surrounded by an outer cladding; a diagnostic solid core optical waveguide comprising a solid core surrounded by a cladding, and extending substantially parallel to the hollow core optical waveguide; and a jacket surrounding both the hollow core optical waveguide and the solid core optical waveguide and forming a common mechanical environment for the hollow core optical waveguide and the solid core optical waveguide. The optical fibre assembly may be or may comprise or be included in an optical fibre cable, and may be used in a method for testing hollow core optical waveguides.

Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, L1, L2, L3, X, a, b, c, n, and m are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity and uses as therapeutics as well as methods for treatment of subjects in need thereof, including prostate cancer are also provided.

Abstract: A visual guide for assisting a user with the positioning of an object relative to the user’s eye is provided. The visual guide comprises: a first positioning indicator provided on an axis; and a second positioning indicator, visually distinct from the first. The first and second positioning indicators are offset along the axis. Furthermore, visual contact of the first and second positioning indicators occurs when the object is located within a predetermined locus of the user’s eye.

Abstract: A device for dispensing a metered dose of fluid is provided. The device comprises a housing comprising: a non-pressurised reservoir sized to accommodate a plurality of doses of fluid; a springloaded metering chamber sized to hold at least a single dose of fluid; a first valve enabling fluid communication between the reservoir and the metering chamber; and a kink valve enabling the fluid in the metering chamber to exit the device.

Abstract: Systems and methods are provided to predict customer behavior during a digital transaction at a point of sale. The disclosed systems and methods can collect information regarding a merchant and the merchant's business as well as information about the current sales environment in which the merchant is operating. From the collected information, the disclosed systems and methods can process the collected information to generate a prediction of future customer behavior in real-time or near real-time.

Abstract: An example device comprises: a cradle to support a resuscitator bag; a paddle arm comprising: a paddle surface disposed opposite the cradle; and a pair of arms extending from the paddle surface; a housing comprising: top, bottom, front and rear sides, and an opening at the front side, towards the top side; the paddle surface extending through the opening; the pair of arms, of the paddle arm, rotatably attached to the housing at an end opposite the paddle surface towards the rear side; a nut assembly rotatably attached to the pair of arms therebetween; a screw threaded through the nut assembly; and a motor rotatably attached to the housing towards the bottom side of the housing; the motor configured to: drive the screw relative to the nut assembly to move the paddle arm towards and away from the cradle, to compress and release the resuscitator bag when located therebetween.

Abstract: Provided are compounds of Formula I and pharmaceutically acceptable salt, solvate and/or derivative thereof. Further, provided are methods of treating a disease, disorder or condition mediated or treatable by activation of SHIP1 comprising administering a compound of Formula I or a pharmaceutically acceptable salt, solvate or derivative thereof. The compound of Formula I or a pharmaceutically acceptable salt, solvate or derivative thereof may be used in the treatment of SHIP1 mediated disease, disorder or conditions including inflammatory bowel disease (IBD), Crohn' disease, ulcerative colitis, multiple myeloma, liver injury, acute hepatitis and severe sepsis.

Abstract: The present invention relates to bifunctional Proteolysis Targeting Chimeric ligands (Protac compounds) comprising a ligase modulator/binder and a molecule that binds to a protein target of interest, and methods of treating various diseases and conditions with the Protac compounds, including diseases associated with androgen receptors.

Abstract: A method, apparatus and system are disclosed for providing a user with an indication of the user's financial security level. In order to achieve this, the user may be surveyed to provide information related to the user's attributes and current level of financial security. Based on the user's inputs, a financial security tool may generate a financial security score and monetary risk amount that provides an accurate interpretation of the user's financial security level.

Abstract: The present invention relates to compounds of formula (I)-(VI) and/or (A)-(H-I), or any subgenera thereof, or a pharmaceutically acceptable salt, tautomer or stereoisomer. The compounds of the present disclosure are useful in modulating androgen receptor activity and for treating cancer including prostate cancer.