Patents by Inventor Raymond Moellering

Raymond Moellering has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR ACTIVATING NRF2-DEPENDENT GENE EXPRESSION
    Publication number: 20220031656
    Abstract: Embodiments are directed to a series of novel small molecule activators of NRF2 dependent gene expression that are evaluated in an effort to develop therapeutic methods against diseases with deregulated KEAP1-NRF2 signaling.
    Type: Application
    Filed: October 14, 2019
    Publication date: February 3, 2022
    Applicant: The University of Chicago
    Inventors: Raymond MOELLERING, John COUKOS, Gihoon LEE, Jae Won CHANG, Gokhan MUTLU
  • Stabilized MAML peptides and uses thereof
    Patent number: 9074009
    Abstract: Stably cross-linked a polypeptides related to human MAML are described. These cross-linked polypeptides contain at least two modified amino acids that together form an internal cross-link or tether that can help to stabilize the alpha-helical secondary structure that is thought to be important for binding of MAML peptides to the Notch transcription complex, a complex that includes ICN and CSL.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: July 7, 2015
    Assignees: Dana-Farber Cancer Institute, Inc., President and Fellows of Harvard College
    Inventors: James Bradner, Raymond Moellering, Gregory L. Verdine
  • STABILIZED MAML PEPTIDES AND USES THEREOF
    Publication number: 20100081611
    Abstract: Stably cross-linked a polypeptides related to human MAML are described. These cross-linked polypeptides contain at least two modified amino acids that together form an internal cross-link or tether that can help to stabilize the alpha-helical secondary structure that is thought to be important for binding of MAML peptides to the Notch transcription complex, a complex that includes ICN and CSL.
    Type: Application
    Filed: June 4, 2009
    Publication date: April 1, 2010
    Inventors: James Bradner, Raymond Moellering, Gregory L. Verdine