Abstract: Provided herein are MAPT RNAi agents and compositions comprising a MAPT RNAi agent. Also provided herein are methods of using the MAPT RNAi agents or compositions comprising a MAPT RNAi agent for reducing MAPT expression and/or treating tauopathy in a subject.

Abstract: Provided herein are MAPT RNAi agents and compositions comprising a MAPT RNAi agent. Also provided herein are methods of using the MAPT RNAi agents or compositions comprising a MAPT RNAi agent for reducing MAPT expression and/or treating tauopathy in a subject.

Abstract: Rifle rests have a base, a rifle support configured to support a forward portion of a rifle, the support movably connected to the base and operable to move vertically and laterally with respect to the base to aim the rifle, an elevation mechanism operably connecting the support to the base and having an adjustable height, a windage mechanism operable to adjust a lateral position of the rifle support with respect to the base, the windage mechanism including an arm having a forward end and opposed rear end, the forward end operably connected to the rifle support to establish a lateral position of the support based on a lateral position of the rear end of the arm, such that lateral movement of the rear end of the arm adjusts the windage of the rifle, and the elevation mechanism including an elevation control element connected to the rear end of the arm.

Abstract: Provided herein are MAPT RNAi agents and compositions comprising a MAPT RNAi agent. Also provided herein are methods of using the MAPT RNAi agents or compositions comprising a MAPT RNAi agent for reducing MAPT expression and/or treating tauopathy in a subject.

Abstract: Rifle rests have a base, a rifle support configured to support a forward portion of a rifle, the support movably connected to the base and operable to move vertically and laterally with respect to the base to aim the rifle, an elevation mechanism operably connecting the support to the base and having an adjustable height, a windage mechanism operable to adjust a lateral position of the rifle support with respect to the base, the windage mechanism including an arm having a forward end and opposed rear end, the forward end operably connected to the rifle support to establish a lateral position of the support based on a lateral position of the rear end of the arm, such that lateral movement of the rear end of the arm adjusts the windage of the rifle, and the elevation mechanism including an elevation control element connected to the rear end of the arm.

Abstract: Rifle rests have a base, a rifle support configured to support a forward portion of a rifle, the support movably connected to the base and operable to move vertically and laterally with respect to the base to aim the rifle, an elevation mechanism operably connecting the support to the base and having an adjustable height, a windage mechanism operable to adjust a lateral position of the rifle support with respect to the base, the windage mechanism including an arm having a forward end and opposed rear end, the forward end operably connected to the rifle support to establish a lateral position of the support based on a lateral position of the rear end of the arm, such that lateral movement of the rear end of the arm adjusts the windage of the rifle, and the elevation mechanism including an elevation control element connected to the rear end of the arm.

Abstract: A window for a radiation detection system includes a frame with an aperture therein configured to receive radiation therethrough. A plurality of silicon ribs span the aperture and are carried by the frame. A coating substantially envelopes each of the plurality of silicon ribs. A thin film covers the aperture and is carried by the plurality of silicon ribs and is configured to pass radiation therethrough.

Abstract: A window for a radiation detection system includes a frame with an aperture therein configured to receive radiation therethrough. A plurality of silicon ribs span the aperture and are carried by the frame. A coating substantially envelopes each of the plurality of silicon ribs. A thin film covers the aperture and is carried by the plurality of silicon ribs and is configured to pass radiation therethrough.

Abstract: An optical system and method for providing a visible light beam with a desired characteristic includes a visible light source producing a visible light beam defining an optical train. An optical element is disposed in the optical train to create a modified beam, and that is capable of introducing an undesired characteristic that continuously transitions across at least a portion of the modified beam. A wire-grid polarizer is disposed in the optical train, and has a plurality of elongated elements with at least a portion that continuously transitions to a different characteristic. The wire-grid polarizer is positioned and oriented in the optical train with the different characteristic corresponding to the undesired characteristic of the modified beam to obtain a visible light beam with a desired characteristic substantially across the visible light beam.

Abstract: A display apparatus includes a cube wire-grid polarizing beam splitter with a plate wire-grid polarizer disposed between a pair of prisms secured together to form a cube. A reflective spatial light modulator produces an image bearing color light beam. The cube wire-grid polarizing beam splitter is disposable in the image bearing color light beam to separate the image information and to produce a polarized image bearing color light beam. A pair of continuous film layers is disposed between the plate wire-grid polarizer and a forward prism with a forward layer adjacent the forward prism having a refractive index greater than both i) a refractive index of a rear layer adjacent the plate wire grid polarizer, and ii) a refractive index of the forward prism. A layer of ribs is disposed between the wires and a rear prism, and the ribs being aligned with and supporting the wires.

Abstract: A cube wire-grid polarizing beam splitter includes a pair of prisms secured together to form a cube. An array of parallel conductive wires is disposed between the pair of prisms. A pair of continuous film layers is disposed on one side of the wires between the wires and one of the pair of prisms with an intermediate film layer adjacent the prism having a refractive index greater than both i) a refractive index of a rear film layer adjacent the plate wire grid polarizer, and ii) a refractive index of an adjacent prism. A layer of ribs is disposed on another side of the wires between the wires and another of the pair of prisms, the ribs being aligned with and supporting the array of parallel conductive wires.

Abstract: An inorganic, dielectric grid polarizer includes an optical stack with a diffraction grating and an inorganic, dielectric grid polarizer. The inorganic, dielectric grid polarizer includes a stack of film layers with an array of parallel ribs in accordance with PGP<?/2 where PGP is the period of the ribs and ? is the wavelength of the light. The diffraction grating includes an array of elongated parallel dielectric ribs in accordance with PDG>?/2 where PDG is the period of the ribs.

Abstract: A mulitlayer wire-grid polarizer for polarizing light includes a stack of thin film layers disposed over a substrate, including a wire-grid array of elongated metal elements having lengths longer than a wavelength of the light and a period less than half the wavelength of the light. One of the layers can include a thin film layer with a refractive index greater than a refractive index of the substrate. One of the thin film layers can include a dielectric array of non-metal elements.

Abstract: An image projection system has a wire grid polarizing beam splitter which functions as both the polarizer and the analyzer in the system. A light source produces a source light beam directed at the beam splitter which reflects one polarization and transmits the other. A liquid crystal array is disposed in either the reflected or transmitted beam. The array modulates the polarization of the beam, encoding image information thereon, and directs the modulated beam back to the beam splitter. The beam splitter again reflects one polarization and transmits the other so that the encoded image is either reflected or transmitted to a screen. The wire grid polarizing beam splitter is capable of being oriented at various incident angles with respect to the source light beam and modulated beam, and accepts relatively divergent light.

Abstract: An optical system and method for providing a visible light beam with a desired characteristic includes a visible light source producing a visible light beam defining an optical train. An optical element is disposed in the optical train to create a modified beam, and that is capable of introducing an undesired characteristic that continuously transitions across at least a portion of the modified beam. A wire-grid polarizer is disposed in the optical train, and has a plurality of elongated elements with at least a portion that continuously transitions to a different characteristic. The wire-grid polarizer is positioned and oriented in the optical train with the different characteristic corresponding to the undesired characteristic of the modified beam to obtain a visible light beam with a desired characteristic substantially across the visible light beam.

Abstract: Isolated nucleic acid molecules encoding polypeptides from a human, reagents related thereto (including purified polypeptides specific antibodies) are provided. Methods of using said reagents and diagnostic kits are also provided.

Abstract: Isolated nucleic acid molecules encoding polypeptides from a human, reagents related thereto (including purified polypeptidesspecific antibodies) are provided. Methods of using said reagentsand diagnostic kits are also provided.

Abstract: A visible light polarizer device includes elements having a different angular orientation with respect to other elements. The elements are sized to interact with visible light to 1) transmit visible light of one polarization orientation, and 2) reflect visible light of another polarization orientation. The device can include 1) primary elements which are substantially parallel with one another, and 2) secondary elements having at least a portion disposed at a different angle orientation with respect to the primary elements. The elements can be configured to transmit visible light of the same first polarization orientation, and reflect visible light of the same second polarization orientation, although they have different angular orientations. Alternatively, the elements can transmit visible light of different polarization orientations.

Abstract: A visible light polarizer device includes elements having a different angular orientation with respect to other elements. The elements are sized to interact with visible light to 1) transmit visible light of one polarization orientation, and 2) reflect visible light of another polarization orientation. The device can include 1) primary elements which are substantially parallel with one another, and 2) secondary elements having at least a portion disposed at a different angle orientation with respect to the primary elements. The elements can be configured to transmit visible light of the same first polarization orientation, and reflect visible light of the same second polarization orientation, although they have different angular orientations. Alternatively, the elements can transmit visible light of different polarization orientations.

Abstract: There is no new technical innovation required in the design of the computer keyboard unit but what is new is the realization that in the workplace windows, carpets, floors and toilets are cleaned for health and safety yet the most logical place which harbors bacteria and viruses and is in constant “unprotected” contact with the hands is the computer keyboard.