Patents by Inventor Raymond T. Testa

Raymond T. Testa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 7-(substituted)-8-(substituted)-9-(substitued amino)-6-demethyl-6-deoxytetracyclines
    Patent number: 5886175
    Abstract: The invention provides compounds of the formulas ##STR1## which are useful as intermediates for the preparation of 6-demethyl-6-deotetracycline antibiotic agents.
    Type: Grant
    Filed: December 8, 1994
    Date of Patent: March 23, 1999
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • 9-[(substituted glycyl) amido)]-6-demethyl-6-deoxytetracyclines
    Patent number: 5567692
    Abstract: The invention provides a method for prevention, treatment or control of bacterial infections in warm blooded animals by administering a pharmacologically effect amount of a compound of the formula: ##STR1## wherein R, R.sup.1 and W are defined in the specification.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: October 22, 1996
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Raymond T. Testa
  • 7-(substituted)-8-(substituted)-9-(substituted amino)-6-demethyl-6-deoxytetracyclines
    Patent number: 5512553
    Abstract: The invention provides compounds of formula ##STR1## wherein X, R and R.sup.1 are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: April 30, 1996
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
    Patent number: 5495030
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.1 and Y are defined in the specification. The compounds are useful for the production of 6-demethyl-6-deoxytracycline derivatives.
    Type: Grant
    Filed: September 1, 1994
    Date of Patent: February 27, 1996
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Raymond T. Testa
  • Process for the production of 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
    Patent number: 5495031
    Abstract: The invention provides a process for the production of compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4 and W are defined in the specification in which a compound of the following formula: ##STR2## is reacted with a nucleophile of the formula WH in an inert atmosphere in the presence of a polar aprotic solvent. The resulting compounds are useful as antibiotics.
    Type: Grant
    Filed: September 13, 1994
    Date of Patent: February 27, 1996
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Raymond T. Testa
  • Process for producing 7-(substituted)-8-(substituted-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
    Patent number: 5495032
    Abstract: The invention provides a process for the production of compounds of the formula: ##STR1## wherein, R, R.sup.3, R.sup.4, X and W are defined in the specification in which a compound of the following formula: ##STR2## is reacted with a nucleophile of the formula WH in an inert atmosphere in the presence of a polar-protic or a polar-aprotic solvent. The resulting compounds are useful as antibiotics.
    Type: Grant
    Filed: September 27, 1994
    Date of Patent: February 27, 1996
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • 7-(substituted-9-(substituted amino)-6-demethyl-6-deoxytetracyclines
    Patent number: 5495018
    Abstract: The invention provides compounds of the formulas ##STR1## which are useful as intermediates for the preparation of 6-demethyl-6-deotetracycline antibiotic agents.
    Type: Grant
    Filed: December 8, 1994
    Date of Patent: February 27, 1996
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
    Patent number: 5466684
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4 and W are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: September 12, 1994
    Date of Patent: November 14, 1995
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Raymond T. Testa
  • 7-(substituted)-8-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
    Patent number: 5457096
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4, X and W are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: October 10, 1995
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
    Patent number: 5442059
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, and R.sup.1 and W are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: August 13, 1992
    Date of Patent: August 15, 1995
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Raymond T. Testa
  • 7-(substituted)-8-(substituted)-9-substituted amino)-6-demethyl-6-deoxytetracyclines
    Patent number: 5430162
    Abstract: The invention provides compounds of formula ##STR1## wherein X, R and R.sup.1 are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: March 21, 1994
    Date of Patent: July 4, 1995
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
    Patent number: 5420272
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4, X and W are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: August 13, 1992
    Date of Patent: May 30, 1995
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
    Patent number: 5401729
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4 and W are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: February 24, 1994
    Date of Patent: March 28, 1995
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Raymond T. Testa
  • 7-(substituted)-8-(substituted)-9-[(substituted glycyl) amido]-6-demethyl-6-deoxytetracyclines
    Patent number: 5386041
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4, X and W are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: February 8, 1994
    Date of Patent: January 31, 1995
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
  • 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
    Patent number: 5380888
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4 and W are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: March 2, 1994
    Date of Patent: January 10, 1995
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Ving J. Lee, Raymond T. Testa
  • 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
    Patent number: 5328902
    Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4 and W are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: August 13, 1992
    Date of Patent: July 12, 1994
    Assignee: American Cyanamid Co.
    Inventors: Phaik-Eng Sum, Ving J. Lee, Raymond T. Testa
  • Method for controlling chronic respiratory disease, fowl cholera and necrotic enteritis in avian species
    Patent number: 4968493
    Abstract: This invention provides a method for treating chronic respiratory disease, fowl cholera and necrotic enteritis in infected birds, by orally administering thereto a pharmaceutically effective amount of antibiotic LL-E19020.alpha., antibiotic LL-E19020.beta. or a physiologically acceptable salt thereof.
    Type: Grant
    Filed: June 19, 1989
    Date of Patent: November 6, 1990
    Assignee: American Cyanamid Company
    Inventors: Guy T. Carter, Michael Greenstein, Joseph J. Goodman, Donald B. Borders, William M. Maiese, Raymond T. Testa
  • Antibiotic LL-C19004
    Patent number: 4870019
    Abstract: A new antibacterial agent designated LL-C19004 is described, which antibacterial agent is produced through microbiological fermentation, under controlled conditions using a new species of Saccharothrix, Saccharothrix espanaensis (NRRL 15764).
    Type: Grant
    Filed: November 21, 1986
    Date of Patent: September 26, 1989
    Assignee: American Cyanamid Company
    Inventors: Jane P. Kirby, Donald B. Borders, May D. Lee, William M. Maiese, Raymond T. Testa, David P. Labeda
  • Culture and process for producing antibiotic LL-D42067alpha
    Patent number: 4774184
    Abstract: The invention is a process for the production by fermentation of the antibacterial and antiparasitic agents designated LL-D42067.alpha., to methods for its recovery and concentration from crude solutions and to processes for its purification. The invention includes within its scope the biologically pure culture of the antibiotic.
    Type: Grant
    Filed: August 14, 1985
    Date of Patent: September 27, 1988
    Assignee: American Cyanamid Company
    Inventors: Taikwang M. Lee, Donald B. Borders, Joseph J. Goodman, Raymond T. Testa, William M. Maiese, David P. Labeda
  • Antibiotic LL-E19020 .alpha. and .beta.
    Patent number: 4705688
    Abstract: This invention relates to antibiotic LL-E19020.alpha. and LL-E19020.beta. derived from the microorganism Streptomyces lydicus subspecies tanzanius NRRL 18036, which are useful as an antibacterial agent.
    Type: Grant
    Filed: June 30, 1986
    Date of Patent: November 10, 1987
    Assignee: American Cyanamid Company
    Inventors: Guy T. Carter, Michael Greenstein, Joseph J. Goodman, Donald B. Borders, William M. Maiese, Raymond T. Testa