Patents by Inventor Raymond W. BOURDEAU

Raymond W. BOURDEAU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LOADING OF EXTRACELLULAR VESICLES THROUGH IMPARTING OF MECHANICAL SHEAR
    Publication number: 20230301917
    Abstract: Methods of loading extracellular vesicles with payload molecules via homogenization are disclosed herein.
    Type: Application
    Filed: October 11, 2022
    Publication date: September 28, 2023
    Applicant: Codiak BioSciences, Inc.
    Inventors: Aaron R. NOYES, Michael P. MERCALDI, Kathryn E. GOLDEN, Raymond W. BOURDEAU, Michael F. DOHERTY, Konstantin KONSTANTINOV, Douglas E. WILLIAMS
  • GAS-FILLED STRUCTURES AND RELATED COMPOSITIONS, METHODS AND SYSTEMS TO IMAGE A TARGET SITE
    Publication number: 20230277695
    Abstract: Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.
    Type: Application
    Filed: October 14, 2022
    Publication date: September 7, 2023
    Inventors: Anupama LAKSHMANAN, Arash FARHADI, Suchita P. NETY, Raymond W. BOURDEAU, Mikhail SHAPIRO
  • Gas-filled structures and related compositions, methods and systems to image a target site
    Patent number: 11504438
    Abstract: Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: November 22, 2022
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Anupama Lakshmanan, Arash Farhadi, Suchita P. Nety, Raymond W. Bourdeau, Mikhail Shapiro
  • METHODS TO IMPROVE POTENCY OF ELECTROPORATION
    Publication number: 20210395721
    Abstract: Compositions and methods for reducing nucleotide oxidation during electroporation, specifically the use of free radical scavengers to reduce electroporation-induced oxidation, are described. Compositions and methods for enhancing transfection efficiency are also described.
    Type: Application
    Filed: October 23, 2019
    Publication date: December 23, 2021
    Applicants: Codiak BioSciences, Inc., MaxCyte, Inc.
    Inventors: Raymond W. BOURDEAU, Delai CHEN, Rane HARRISON, Kathryn E. GOLDEN, Douglas E. WILLIAMS, Sergey DZEKUNOV, Madhusudan PESHWA
  • GENETICALLY ENGINEERED GAS VESICLE GENE CLUSTERS, GENETIC CIRCUITS, VECTORS, PROKARYOTIC CELLS, COMPOSITIONS, METHODS AND SYSTEMS FOR CONTRAST-ENHANCED IMAGING
    Publication number: 20210301298
    Abstract: Hybrid gas vesicle gene cluster (GVGC) configured for expression in a prokaryotic host are described comprising gas vesicle assembly (GVA) genes native to a GVA prokaryotic species and capable of being expressed in a functional form in the prokaryotic host, and one or more gas vesicle structural (GVS) genes native to one or more GVS prokaryotic species, at least one of the one or more GVS prokaryotic species different from the GVA prokaryotic species, and related gas vesicle reporting (GVR) genetic circuits, genetic, vectors, engineered cells, and related compositions methods and systems to produce GVs, hybrid GVGC and/or image a target site.
    Type: Application
    Filed: May 31, 2021
    Publication date: September 30, 2021
    Inventors: Raymond W. BOURDEAU, Anupama LAKSHMANAN, Arash FARHADI, Mikhail G. SHAPIRO, Audrey LEE-GOSSELIN
  • Genetically engineered gas vesicle gene clusters, genetic circuits, vectors, prokaryotic cells, compositions, methods and systems for contrast-enhanced imaging
    Patent number: 11118210
    Abstract: Hybrid gas vesicle gene cluster (GVGC) configured for expression in a prokaryotic host are described comprising gas vesicle assembly (GVA) genes native to a GVA prokaryotic species and capable of being expressed in a functional form in the prokaryotic host, and one or more gas vesicle structural (GVS) genes native to one or more GVS prokaryotic species, at least one of the one or more GVS prokaryotic species different from the GVA prokaryotic species, and related gas vesicle reporting (GVR) genetic circuits, genetic, vectors, engineered cells, and related compositions methods and systems to produce GVs, hybrid GVGC and/or image a target site.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: September 14, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Raymond W. Bourdeau, Anupama Lakshmanan, Arash Farhadi, Mikhail G. Shapiro, Audrey Lee-Gosselin
  • LOADING OF EXTRACELLULAR VESICLES THROUGH IMPARTING OF MECHANICAL SHEAR
    Publication number: 20210093568
    Abstract: Methods of loading extracellular vesicles with payload molecules via homogenization are disclosed herein.
    Type: Application
    Filed: September 8, 2020
    Publication date: April 1, 2021
    Inventors: Aaron R. NOYES, Michael P. MERCALDI, Kathryn E. GOLDEN, Raymond W. BOURDEAU, Michael F. DOHERTY, Konstantin KONSTANTINOV, Douglas E. WILLIAMS
  • GAS-FILLED STRUCTURES AND RELATED COMPOSITIONS, METHODS AND SYSTEMS TO IMAGE A TARGET SITE
    Publication number: 20200164095
    Abstract: Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.
    Type: Application
    Filed: October 17, 2019
    Publication date: May 28, 2020
    Inventors: Anupama LAKSHMANAN, Arash FARHADI, Suchita P. NETY, Raymond W. BOURDEAU, Mikhail SHAPIRO
  • Gas-filled structures and related compositions, methods and systems to image a target site
    Patent number: 10493172
    Abstract: Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: December 3, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Anupama Lakshmanan, Arash Farhadi, Suchita P. Nety, Raymond W. Bourdeau, Mikhail Shapiro
  • Loading of Extracellular Vesicles through Imparting of Mechanical Shear
    Publication number: 20190175506
    Abstract: Methods of loading extracellular vesicles with payload molecules via homogenization are disclosed herein.
    Type: Application
    Filed: November 13, 2018
    Publication date: June 13, 2019
    Inventors: Aaron R. Noyes, Michael P. Mercaldi, Kathryn E. Golden, Raymond W. Bourdeau, Michael F. Doherty, Konstantin Konstantinov, Douglas E. Williams
  • GAS-FILLED STRUCTURES AND RELATED COMPOSITIONS, METHODS AND SYSTEMS TO IMAGE A TARGET SITE
    Publication number: 20180028693
    Abstract: Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.
    Type: Application
    Filed: June 2, 2017
    Publication date: February 1, 2018
    Inventors: Anupama LAKSHMANAN, Arash FARHADI, Suchita P. NETY, Raymond W. BOURDEAU, Mikhail SHAPIRO
  • GENETICALLY ENGINEERED GAS VESICLE GENE CLUSTERS, GENETIC CIRCUITS, VECTORS, PROKARYOTIC CELLS, COMPOSITIONS, METHODS AND SYSTEMS FOR CONTRAST-ENHANCED IMAGING
    Publication number: 20180030501
    Abstract: Hybrid gas vesicle gene cluster (GVGC) configured for expression in a prokaryotic host are described comprising gas vesicle assembly (GVA) genes native to a GVA prokaryotic species and capable of being expressed in a functional form in the prokaryotic host, and one or more gas vesicle structural (GVS) genes native to one or more GVS prokaryotic species, at least one of the one or more GVS prokaryotic species different from the GVA prokaryotic species, and related gas vesicle reporting (GVR) genetic circuits, genetic, vectors, engineered cells, and related compositions methods and systems to produce GVs, hybrid GVGC and/or image a target site.
    Type: Application
    Filed: July 28, 2017
    Publication date: February 1, 2018
    Inventors: Raymond W. BOURDEAU, Anupama LAKSHMANAN, Arash FARHADI, Mikhail G. SHAPIRO, Audrey LEE-GOSSELIN