Patents by Inventor Razvan Ioan Ionasec
Razvan Ioan Ionasec has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10719986Abstract: A method and system for virtual percutaneous valve implantation is disclosed. A patient-specific anatomical model of a heart valve is estimated based on 3D cardiac medical image data and an implant model representing a valve implant is virtually deployed into the patient-specific anatomical model of the heart valve. A library of implant models, each modeling geometrical properties of a corresponding valve implant, is maintained. The implant models maintained in the library are virtually deployed into the patient specific anatomical model of the heart valve to select an implant type and size and deployment location and orientation for percutaneous valve implantation.Type: GrantFiled: December 22, 2010Date of Patent: July 21, 2020Assignee: Siemens Healthcare GmbHInventors: Dominik Zaeuner, Razvan Ioan Ionasec, Bogdan Georgescu, Yefeng Zheng, Dorin Comaniciu, Ingmar Voigt, Jan Boese
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Patent number: 9824302Abstract: A method and system for fusion of multi-modal volumetric images is disclosed. A first image acquired using a first imaging modality is received. A second image acquired using a second imaging modality is received. A model and of a target anatomical structure and a transformation are jointly estimated from the first and second images. The model represents a model of the target anatomical structure in the first image and the transformation projects a model of the target anatomical structure in the second image to the model in the first image. The first and second images can be fused based on estimated transformation.Type: GrantFiled: March 6, 2012Date of Patent: November 21, 2017Assignee: Siemens Healthcare GmbHInventors: Sasa Grbic, Razvan Ioan Ionasec, Yang Wang, Bogdan Georgescu, Tommaso Mansi, Dorin Comaniciu, Yefeng Zheng, Shaohua Kevin Zhou, Matthias John, Jan Boese
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Patent number: 9730609Abstract: A method and system for automatic aortic valve calcification evaluation is disclosed. A patient-specific aortic valve model in a 3D medical image volume, such as a 3D computed tomography (CT) volume. Calcifications in a region of the 3D medical image volume defined based on the aortic valve model. A 2D calcification plot is generated that shows locations of the segmented calcifications relative to aortic valve leaflets of the patient-specific aortic valve model. The 2D calcification plot can be used for assessing the suitability of a patient for a Transcatheter Aortic Valve Replacement (TAVI) procedure, as well as risk assessment, positioning of an aortic valve implant, and selection of a type of aortic valve implant.Type: GrantFiled: December 13, 2012Date of Patent: August 15, 2017Assignee: Siemens Healthcare GmbHInventors: Sasa Grbic, Razvan Ioan Ionasec, Fernando Vega-Higuera, Dominik Bernhardt, Dorin Comaniciu
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Patent number: 9687204Abstract: A method and system for registering ultrasound images and physiological models to x-ray fluoroscopy images is disclosed. A fluoroscopic image and an ultrasound image, such as a Transesophageal Echocardiography (TEE) image, are received. A 2D location of an ultrasound probe is detected in the fluoroscopic image. A 3D pose of the ultrasound probe is estimated based on the detected 2D location of the ultrasound probe in the fluoroscopic image. The ultrasound image is mapped to a 3D coordinate system of a fluoroscopic image acquisition device used to acquire the fluoroscopic image based on the estimated 3D pose of the ultrasound probe. The ultrasound image can then be projected into the fluoroscopic image using a projection matrix associated with the fluoroscopic image. A patient specific physiological model can be detected in the ultrasound image and projected into the fluoroscopic image.Type: GrantFiled: May 18, 2012Date of Patent: June 27, 2017Assignee: Siemens Healthcare GmbHInventors: Peter Mountney, Markus Kaiser, Ingmar Voigt, Matthias John, Razvan Ioan Ionasec, Jan Boese, Dorin Comaniciu
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Patent number: 9681856Abstract: A method for real-time fusion of a 2D cardiac ultrasound image with a 2D cardiac fluoroscopic image includes acquiring real time synchronized US and fluoroscopic images, detecting a surface contour of an aortic valve in the 2D cardiac ultrasound (US) image relative to an US probe, detecting a pose of the US probe in the 2D cardiac fluoroscopic image, and using pose parameters of the US probe to transform the surface contour of the aortic valve from the 2D cardiac US image to the 2D cardiac fluoroscopic image.Type: GrantFiled: December 15, 2015Date of Patent: June 20, 2017Assignee: Siemens AktiengesellschaftInventors: Peter Mountney, Sasa Grbic, Razvan Ioan Ionasec, Matthias John, Dorin Comaniciu
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Patent number: 9259200Abstract: Methods, systems, and apparatus for obtaining a sequence of x-ray images are disclosed. An object of interest in a first x-ray image is detected and an area of interest, based on a predicted motion of the object of interest, is determined. A second x-ray image of the area of interest is acquired using spatial x-ray modification to control an x-ray to pass through a portion of a patient corresponding to the area of interest.Type: GrantFiled: October 18, 2012Date of Patent: February 16, 2016Assignee: SIEMENS AKTIENGESELLSCHAFTInventors: Peter Mountney, Andreas Maier, Razvan Ioan Ionasec, Jan Boese, Dorin Comaniciu
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Patent number: 9245091Abstract: Physically-constrained modeling of a heart is provided. Patient-specific data may be used to estimate heart anatomy locations. A model is applied to the data for estimation. For increased accuracy of estimation, the biomechanics of the heart, such as the valve, may be used to constrain the estimation. By applying a dynamic system between estimated anatomy locations of different times, the locations may be deformed or refined. The modeled heart and/or valve may be used to estimate hemodynamics. The resulting velocities or other motion information may be used to emulate ultrasound Doppler imaging for comparing with acquired ultrasound Doppler data. The comparison may validate the modeling.Type: GrantFiled: March 9, 2012Date of Patent: January 26, 2016Assignees: Siemens Aktiengesellschaft, Siemens Corporation, Siemens Medical Solutions USA, Inc.Inventors: Ingmar Voigt, Razvan Ioan Ionasec, Bogdan Georgescu, Tommaso Mansi, Dorin Comaniciu, Helene C. Houle, Etienne Assoumou Mengue
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Patent number: 9196049Abstract: A system and method for regression-based segmentation of the mitral valve in 2D+t cardiac magnetic resonance (CMR) slices is disclosed. The 2D+t CMR slices are acquired according to a mitral valve-specific acquisition protocol introduced herein. A set of mitral valve landmarks is detected in each 2D CMR slice and mitral valve contours are estimated in each 2D CMR slice based on the detected landmarks. A full mitral valve model is reconstructed from the mitral valve contours estimated in the 2D CMR slices using a trained regression model. Each 2D CMR slice may be a cine image acquired over a full cardiac cycle. In this case, the segmentation method reconstructs a patient-specific 4D dynamic mitral valve model from the 2D+t CMR image data.Type: GrantFiled: March 9, 2012Date of Patent: November 24, 2015Assignee: Siemens AktiengesellschaftInventors: Razvan Ioan Ionasec, Dime Vitanovski, Alexey Tsymbal, Gareth Funka-Lea, Dorin Comaniciu, Andreas Greiser, Edgar Mueller
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Patent number: 9179890Abstract: Different intracardiac echocardiography volumes are stitched together. Different volumes of a patient are scanned with ICE. To stitch the volumes together, creating a larger volume, the volumes are spatially aligned. The alignment is based on feature, surface, or both feature and surface matching of the ICE volumes with a preoperative model of the same patient. The matching with the model indicates a relative position of the ICE volumes with each other. Using machine-trained classifiers may speed performance, allowing for real-time assembling of a volume from ICE data as the catheter is moved within the patient.Type: GrantFiled: July 11, 2012Date of Patent: November 10, 2015Assignees: Siemens Aktiengesellschaft, Siemens Medical Solutions USA, Inc.Inventors: Razvan Ioan Ionasec, Sasa Grbic, Estelle Camus, Dorin Comaniciu
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Patent number: 9135699Abstract: A method and system for non-invasive hemodynamic assessment of aortic coarctation from medical image data, such as magnetic resonance imaging (MRI) data is disclosed. Patient-specific lumen anatomy of the aorta and supra-aortic arteries is estimated from medical image data of a patient, such as contrast enhanced MRI. Patient-specific aortic blood flow rates are estimated from the medical image data of the patient, such as velocity encoded phase-contrasted MRI cine images. Patient-specific inlet and outlet boundary conditions for a computational model of aortic blood flow are calculated based on the patient-specific lumen anatomy, the patient-specific aortic blood flow rates, and non-invasive clinical measurements of the patient. Aortic blood flow and pressure are computed over the patient-specific lumen anatomy using the computational model of aortic blood flow and the patient-specific inlet and outlet boundary conditions.Type: GrantFiled: March 14, 2013Date of Patent: September 15, 2015Assignee: Siemens AktiengesellschaftInventors: Kristof Ralovich, Lucian Mihai Itu, Viorel Mihalef, Puneet Sharma, Razvan Ioan Ionasec, Dime Vitanovski, Waldemar Krawtschuk, Dorin Comaniciu
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Patent number: 9033887Abstract: A mitral valve is detected in transthoracic echocardiography. The ultrasound transducer is positioned against the chest of the patient rather than being inserted within the patient. While data acquired from such scanning may be noisier or have less resolution, the mitral valve may still be automatically detected. Using both B-mode data representing tissue as well as flow data representing the regurgitant jet, the mitral valve may be detected automatically with a machine-learnt classifier. A series of classifiers may be used, such as determining a position and orientation of a valve region with one classifier, determining a regurgitant orifice with another classifier, and locating mitral valve anatomy with a third classifier. One or more features for some of the classifiers may be calculated based on the orientation of the valve region.Type: GrantFiled: May 30, 2013Date of Patent: May 19, 2015Assignees: Siemens Corporation, Siemens Medical Solutions USA, Inc., Siemens AktiengesellschaftInventors: Razvan Ioan Ionasec, Dime Vitanovski, Yang Wang, Bogdan Georgescu, Ingmar Voigt, Saurabh Datta, Dorin Comaniciu
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Patent number: 8983809Abstract: A method and system for assessment of virtual stent implantation in an aortic aneurysm is disclosed. A patient-specific 4D anatomical model of the aorta is generated from the 4D medical imaging data. A model representing mechanical properties of the aorta wall is adjusted to reflect changes due to aneurysm growth at a plurality of time stages. A stable deformation configuration of the aorta is generated for each time stages by performing fluid structure interaction (FSI) simulations using the patient-specific 4D anatomical model at each time stage based on the adjusted model representing the mechanical properties of the aorta wall at each time stage. Virtual stent implantation is performed for each stable deformation configuration of the aorta and FSI simulations are performed for each virtual stent implantation.Type: GrantFiled: December 6, 2011Date of Patent: March 17, 2015Assignee: Siemens AktiengesellschaftInventors: Puneet Sharma, Viorel Mihalef, Razvan Ioan Ionasec, Bogdan Georgescu, Dorin Comaniciu
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Patent number: 8934693Abstract: A method and system for automated intervention planning for transcatheter aortic valve implantations using computed tomography (CT) data is disclosed. A patient-specific aortic valve model is detected in a CT volume of a patient. The patient-specific aortic valve model is detected by detecting a global location of the patient-specific aortic valve model in the CT volume, detecting aortic valve landmarks based on the detected global location, and fitting an aortic root surface model. Angulation parameters of a C-arm imaging device for acquiring intra-operative fluoroscopic images and anatomical measurements of the aortic valve are automatically determined based on the patient-specific aortic valve model.Type: GrantFiled: November 21, 2012Date of Patent: January 13, 2015Assignee: Siemens AktiengesellschaftInventors: Sasa Grbic, Razvan Ioan Ionasec, Fernando Vega-Higuera, Dominik Bernhardt, Bogdan Georgescu, Dorin Comaniciu
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Patent number: 8920322Abstract: Valve treatment simulation is performed from patient specific imaging data for therapy planning. A model of the valve may be generated from the patient specific data automatically or with very minimal user indication of anatomy locations relative to an image. Any characteristics for the valve not extracted from images of the patient may be added to create a volumetric model. Added characteristics include chordae, such as chordae length and leaflet fiber direction. The characteristics may be adjusted based on user feedback and/or comparison with images of the patient. The effect of therapy on closure of the valve may be simulated from the model. For instance, mitral clip intervention is simulated on the patient-specific model. Valves are deformed according to the clip location. Valve closure is then simulated to predict effect of the therapy in terms of mitral regurgitation.Type: GrantFiled: March 5, 2012Date of Patent: December 30, 2014Assignee: Siemens AktiengesellschaftInventors: Tommaso Mansi, Ingmar Voigt, Razvan Ioan Ionasec, Bogdan Georgescu, Dorin Comaniciu, Etienne Assoumou Mengue
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Patent number: 8812431Abstract: A method and system for providing medical decision support based on virtual organ models and learning based discriminative distance functions is disclosed. A patient-specific virtual organ model is generated from medical image data of a patient. One or more similar organ models to the patient-specific organ model are retrieved from a plurality of previously stored virtual organ models using a learned discriminative distance function. The patient-specific valve model can be classified into a first class or a second class based on the previously stored organ models determined to be similar to the patient-specific organ model.Type: GrantFiled: January 28, 2011Date of Patent: August 19, 2014Assignee: Siemens AktiengesellschaftInventors: Ingmar Voigt, Dime Vitanovski, Razvan Ioan Ionasec, Alexey Tsymbal, Bogdan Georgescu, Shaohua Kevin Zhou, Martin Huber, Dorin Comaniciu
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Patent number: 8771189Abstract: Heart valve operation is assessed with patient-specific medical diagnostic imaging data. To deal with the complex motion of the passive valve tissue, a hierarchal model is used. Rigid global motion of the overall valve, non-rigid local motion of landmarks of the valve, and surface motion of the valve are modeled sequentially. For the non-rigid local motion, a spectral trajectory approach is used in the model to determine location and motion of the landmarks more efficiently than detection and tracking. Given efficiencies in processing, more than one valve may be modeled at a same time. A graphic overlay representing the valve in four dimensions and/or quantities may be provided during an imaging session. One or more of these features may be used in combination or independently.Type: GrantFiled: February 8, 2010Date of Patent: July 8, 2014Assignees: Siemens Medical Solutions USA, Inc., Siemens Corporation, Siemens AktiengesellschaftInventors: Razvan Ioan Ionasec, Ingmar Voigt, Yang Wang, Bogdan Georgescu, Helene C. Houle, Dorin Comaniciu, Fernando Vega-Higuera
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Publication number: 20140112438Abstract: Methods, systems, and apparatus for obtaining a sequence of x-ray images are disclosed. An object of interest in a first x-ray image is detected and an area of interest, based on a predicted motion of the object of interest, is determined. A second x-ray image of the area of interest is acquired using spatial x-ray modification to control an x-ray to pass through a portion of a patient corresponding to the area of interest.Type: ApplicationFiled: October 18, 2012Publication date: April 24, 2014Applicant: SIEMENS AKTIENGESELLSCHAFTInventors: Peter Mountney, Andreas Maier, Razvan Ioan Ionasec, Jan Boese, Dorin Comaniciu
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Patent number: 8682626Abstract: A method and system for patient-specific modeling of the whole heart anatomy, dynamics, hemodynamics, and fluid structure interaction from 4D medical image data is disclosed. The anatomy and dynamics of the heart are determined by estimating patient-specific parameters of a physiological model of the heart from the 4D medical image data for a patient. The patient-specific anatomy and dynamics are used as input to a 3D Navier-Stokes solver that derives realistic hemodynamics, constrained by the local anatomy, along the entire heart cycle. Fluid structure interactions are determined iteratively over the heart cycle by simulating the blood flow at a given time step and calculating the deformation of the heart structure based on the simulated blood flow, such that the deformation of the heart structure is used in the simulation of the blood flow at the next time step.Type: GrantFiled: April 20, 2011Date of Patent: March 25, 2014Assignee: Siemens AktiengesellschaftInventors: Razvan Ioan Ionasec, Ingmar Voigt, Viorel Mihalef, Sasa Grbic, Dime Vitanovski, Yang Wang, Yefeng Zheng, Bogdan Georgescu, Dorin Comaniciu, Puneet Sharma, Tommaso Mansi
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Publication number: 20140052001Abstract: A mitral valve is detected in transthoracic echocardiography. The ultrasound transducer is positioned against the chest of the patient rather than being inserted within the patient. While data acquired from such scanning may be noisier or have less resolution, the mitral valve may still be automatically detected. Using both B-mode data representing tissue as well as flow data representing the regurgitant jet, the mitral valve may be detected automatically with a machine-learnt classifier. A series of classifiers may be used, such as determining a position and orientation of a valve region with one classifier, determining a regurgitant orifice with another classifier, and locating mitral valve anatomy with a third classifier. One or more features for some of the classifiers may be calculated based on the orientation of the valve region.Type: ApplicationFiled: May 30, 2013Publication date: February 20, 2014Inventors: Razvan Ioan Ionasec, Dime Vitanovski, Yang Wang, Bogdan Georgescu, Ingmar Voigt, Saurabh Datta, Dorin Comaniciu
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Publication number: 20130294667Abstract: A method and system for model based fusion pre-operative image data, such as computed tomography (CT), and intra-operative C-arm CT is disclosed. A first pericardium model is segmented in the pre-operative image data and a second pericardium model is segmented in a C-arm CT volume. A deformation field is estimated between the first pericardium model and the second pericardium model. A model of a target cardiac structure, such as a heart chamber model or an aorta model, extracted from the pre-operative image data is fused with the C-arm CT volume based on the estimated deformation field between the first pericardium model and the second pericardium model. An intelligent weighted average may be used improve the model based fusion results using models of the target cardiac structure extracted from pre-operative image data of patients other than a current patient.Type: ApplicationFiled: February 13, 2013Publication date: November 7, 2013Applicants: Siemens Aktiengesellschaft, Siemens CorporationInventors: Yefeng Zheng, Razvan Ioan Ionasec, Sasa Grbic, Matthias John, Dorin Comaniciu