Patents by Inventor Rebecca C. Fitzgerald
Rebecca C. Fitzgerald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10551392Abstract: The present invention, relates to the use of TFF3 in the diagnosis and detection of Barrett's Oesophagus using non-invasive, non-endoscopic methods.Type: GrantFiled: March 21, 2017Date of Patent: February 4, 2020Assignee: Covidien LPInventors: Pierre Lao-Sirieix, Rebecca C. Fitzgerald
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Patent number: 10327742Abstract: A swallowable cell sampling device comprising an abrasive material capable of collecting cells from the surface of the oesophagus is described. The swallowable cell sampling device may include an apparatus for retrieval comprising a cord. Moreover, the cord may be attached to the abrasive material with a hitch knot. Additionally, kits and methods involving the same are described.Type: GrantFiled: November 11, 2010Date of Patent: June 25, 2019Assignee: UNITED KINGDOM RESEARCH AND INNOVATIONInventors: Rebecca C. Fitzgerald, Suni Sudarshan R. Kadri, Pierre Lao-Sirieix
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Patent number: 10088482Abstract: The present invention relates to a method of aiding in the prognosis of a subject with oesophageal and/or gastro-oesophageal junctional (GOJ) adenocarcinoma, the method comprising the steps of: (a) providing a sample from the subject, (b) determining the expression level of biomarkers TRIM44 and SIRT2 in said sample, and either (i) determining the expression level of biomarker PAPPS2 in said sample; or (ii) determining the expression level of biomarkers WT1 and EGFR in said sample; (c) comparing the expression level of each of said biomarkers to a corresponding reference standard, (d) determining the biomarkers of (b) whose expression is dysregulated compared to the reference standard, (e) inferring from the dysregulated biomarkers identified in (d) the prognosis of 5-year survival, wherein the greater the number of said biomarkers which are dysregulated, the greater the reduction in prognosis of 5-year survival. The invention also relates to kits, uses and devices.Type: GrantFiled: October 7, 2016Date of Patent: October 2, 2018Assignees: Cambridge Enterprise Limited, United Kingdom Research and InnovationInventors: Christopher J. Peters, Carlos Caldas, Rebecca C. Fitzgerald
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Publication number: 20180208991Abstract: Some embodiments are directed to a method of aiding the diagnosis of dysplasia in a subject that includes providing a sample from the oesophagus of the subject; assaying the sample for expression of each of the genes shown in the ‘40 genes’ column of Table 1; normalising the expression levels of the genes in step (b) to expression levels of reference gene(s) from a non-dysplastic sample; and determining from the normalised expression levels of step (c) a gene signature score for the sample, wherein a gene signature score greater than a reference threshold indicates presence of dysplasia in the subject. Some embodiments also relate to devices, compositions, primer sets, arrays, methods of treatment and computer programs.Type: ApplicationFiled: July 1, 2016Publication date: July 26, 2018Inventors: Rebecca C. FITZGERALD, Sibu VARGHESE, Richard NEWTON, Lorenz WERNISCH
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Publication number: 20180074075Abstract: The present invention, relates to the use of TFF3 in the diagnosis and detection of Barrett's Oesophagus using non-invasive, non-endoscopic methods.Type: ApplicationFiled: March 21, 2017Publication date: March 15, 2018Inventors: PIERRE LAO-SIRIEIX, REBECCA C. FITZGERALD
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Patent number: 9632099Abstract: The present invention, relates to the use of TFF3 in the diagnosis and detection of Barrett's Oesophagus using non-invasive, non-endoscopic methods.Type: GrantFiled: February 7, 2014Date of Patent: April 25, 2017Assignee: Medical Research CouncilInventors: Pierre Lao-Sirieix, Rebecca C. Fitzgerald
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Patent number: 9606122Abstract: The present invention relates to a method of aiding in the prognosis of a subject with oesophageal and/or gastro-oesophageal junctional (GOJ) adenocarcinoma, the method comprising the steps of: (a) providing a sample from the subject, (b) determining the expression level of biomarkers TRIM44 and SIRT2 in said sample, and either (i) determining the expression level of biomarker PAPPS2 in said sample; or (ii) determining the expression level of biomarkers WT1 and EGFR in said sample; (c) comparing the expression level of each of said biomarkers to a corresponding reference standard, (d) determining the biomarkers of (b) whose expression is dysregulated compared to the reference standard, (e) inferring from the dysregulated biomarkers identified in (d) the prognosis of 5-year survival, wherein the greater the number of said biomarkers which are dysregulated, the greater the reduction in prognosis of 5-year survival. The invention also relates to kits, uses and devices.Type: GrantFiled: March 24, 2011Date of Patent: March 28, 2017Assignees: Cambridge Enterprise Limited, Medical Research CouncilInventors: Christopher J. Peters, Carlos Caldas, Rebecca C. Fitzgerald
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Publication number: 20170074880Abstract: The present invention relates to a method of aiding in the prognosis of a subject with oesophageal and/or gastro-oesophageal junctional (GOJ) adenocarcinoma, the method comprising the steps of: (a) providing a sample from the subject, (b) determining the expression level of biomarkers TRIM44 and SIRT2 in said sample, and either (i) determining the expression level of biomarker PAPPS2 in said sample; or (ii) determining the expression level of biomarkers WT1 and EGFR in said sample; (c) comparing the expression level of each of said biomarkers to a corresponding reference standard, (d) determining the biomarkers of (b) whose expression is dysregulated compared to the reference standard, (e) inferring from the dysregulated biomarkers identified in (d) the prognosis of 5-year survival, wherein the greater the number of said biomarkers which are dysregulated, the greater the reduction in prognosis of 5-year survival. The invention also relates to kits, uses and devices.Type: ApplicationFiled: October 7, 2016Publication date: March 16, 2017Inventors: Christopher J. Peters, Carlos Caldas, Rebecca C. Fitzgerald
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Publication number: 20150004622Abstract: The present invention, relates to the use of TFF3 in the diagnosis and detection of Barrett's Oesophagus using non-invasive, non-endoscopic methods.Type: ApplicationFiled: February 7, 2014Publication date: January 1, 2015Applicant: Medical Research CouncilInventors: PIERRE LAO-SIRIEIX, REBECCA C. FITZGERALD
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Publication number: 20140323908Abstract: The invention relates to a method for detecting a foreign cell in a tissue of the upper intestinal tract, sold method comprising: (a) providing a sample of cells from the epithelium layer of the tissue of interest; (b) preparing the cells into a cohesive cluster; (c) staining cells from the cohesive cluster using haematoxylin and eosin (H&E) stain; (d) observing the stained cells; and (e) inferring the presence or absence of foreign cell(s) from the observations of Id), The invention also relates to a method for aiding the diagnosis of an inflammatory condition of the upper intestinal tract in a subject, said method comprising detecting a foreign cell as described above, wherein detection of foreign cell(s) in step (e) infers that the subject has an inflammatory condition of the upper intestinal tract.Type: ApplicationFiled: May 22, 2014Publication date: October 30, 2014Inventors: REBECCA C. FITZGERALD, MARIA O'DONOVAN
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Patent number: 8709736Abstract: The present invention relates to the use of TFF3 in the diagnosis and detection of Barrett's esophagus using non-invasive, non-endoscopic methods.Type: GrantFiled: July 9, 2010Date of Patent: April 29, 2014Assignee: Medical Research CouncilInventors: Pierre Lao-Sirieix, Rebecca C. Fitzgerald
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Publication number: 20130065785Abstract: The present invention relates to a method of aiding in the prognosis of a subject with oesophageal and/or gastro-oesophageal junctional (GOJ) adenocarcinoma, the method comprising the steps of: (a) providing a sample from the subject, (b) determining the expression level of biomarkers TRIM44 and SIRT2 in said sample, and either (i) determining the expression level of biomarker PAPPS2 in said sample; or (ii) determining the expression level of biomarkers WT1 and EGFR in said sample; (c) comparing the expression level of each of said biomarkers to a corresponding reference standard, (d) determining the biomarkers of (b) whose expression is dysregulated compared to the reference standard, (e) inferring from the dysregulated biomarkers identified in (d) the prognosis of 5-year survival, wherein the greater the number of said biomarkers which are dysregulated, the greater the reduction in prognosis of 5-year survival. The invention also relates to kits, uses and devices.Type: ApplicationFiled: March 24, 2011Publication date: March 14, 2013Applicants: CAMBRIDGE ENTERPRISE LIMITED, MEDICAL RESEARCH COUNCILInventors: Christopher J. Peters, Carlos Caldas, Rebecca C. Fitzgerald
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Publication number: 20120226189Abstract: The invention relates to a swallowable cell sampling device comprising an abrasive material capable of collecting cells from the surface of the oesophagus, and a means for retrieval wherein the means for retrieval comprises a cord, characterised in that the cord is attached to the abrasive material by means of a hitch knot. The invention also relates to kits and methods involving same.Type: ApplicationFiled: November 11, 2010Publication date: September 6, 2012Applicant: Medical Research CouncilInventors: Rebecca C. Fitzgerald, Suni Sudarshan R. Kadri, Pierre Lao-Sirieix
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Publication number: 20120009597Abstract: The present invention relates to the use of TFF3 in the diagnosis and detection of Barrett's Oesophagus using non-invasive, non-endoscopic methods.Type: ApplicationFiled: July 9, 2010Publication date: January 12, 2012Applicant: MEDICAL RESEARCH COUNCILInventors: Pierre Lao-Sirieix, Rebecca C. Fitzgerald
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Publication number: 20090286237Abstract: The invention relates to kits and methods for aiding the diagnosis of Barrett's oesophagus or Barrett's associated dysplasia. Preferred is a method comprising assaying cells from the surface of a subject's oesophagus for a non-squamous cellular marker, wherein detection of such a marker indicates increased likelihood of the presence of Barrett's or Barrett's associated dysplasia, preferably wherein said sample of cells is not directed to a particular site within the oesophagus. The invention also encompasses a method comprising sampling the cellular surface of the oesophagus of said subject. The invention also relates to a kit comprising a swallowable device comprising abrasive material capable of collecting cells from the surface of the oesophagus, together with printed instructions for its use in detection of Barrett's oesophagus or Barrett's associated dysplasia. Preferably said device comprises a capsule sponge.Type: ApplicationFiled: October 20, 2006Publication date: November 19, 2009Applicants: Medical Research Council, Cambridge EnterprieseInventors: Rebecca C. Fitzgerald, Richard Hardwick