Patents by Inventor Rebecca EPPERLY

Rebecca EPPERLY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GRP78 TARGETED ADOPTIVE CELL THERAPY
    Publication number: 20230312671
    Abstract: The present invention provides a chimeric antigen receptor (CAR) comprising an extracellular target-binding domain comprising at least one glucose-regulated-protein 78 (GRP78)-binding moiety. The present invention further provides polynucleotides and recombinant vectors encoding such CARs. The present invention further provides isolated host cells and methods for preparing isolated host cells expressing the CARs. The present invention further provides pharmaceutical compositions comprising the host cells and methods for treating a tumor using the pharmaceutical compositions.
    Type: Application
    Filed: April 23, 2021
    Publication date: October 5, 2023
    Applicant: St. Jude Children's Research Hospital, Inc.
    Inventors: Mireya Paulina VELASQUEZ, Stephen GOTTSCHALK, Nikhil HEBBAR, Rebecca EPPERLY, Abishek VAIDYA