Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, bonds a, b, c and d, X1, X2, X3, X4, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: In accordance with the present invention, a waveguide grating comprises a core and a first cladding material adjacent the core. The first cladding is configured, as by etching, to provide a periodic grating, and a second cladding material having a controllable refractive index overlies the first cladding material. If the index of the second cladding is different from that of the first cladding, the configuration of the first cladding provides an optical grating. If, however, the controllable index of the second cladding is adjusted to equal that of the first cladding, the grating becomes essentially transparent. This grating is particularly useful as a reconfigurable add/drop filter in a WDM optical communication system. It is also useful in grating-assisted couplers and variable optical delay lines.

Abstract: In accordance with the invention, a tunable optical all-pass filter with a substrate-supported multilayer waveguiding structure. A first layer including a waveguiding optical ring resonator, a second layer for spacing, and a third layer including a curved waveguide. The curved waveguide is optically coupled to the resonator by two spaced apart optical couplers extending through the spacing layer, and tunability is provided by a first phase-shifter to control the optical pathlength of the resonator and a second phase-shifter operative on the waveguide to control the strength of coupling between the waveguide and the resonator. In one embodiment, the waveguide and the resonator are horizontally spaced apart in the non-coupling regions to provide optical isolation. In another, the waveguide and resonator can overlap horizontally, but the spacer layer is thicker in the non-coupling regions to provide optical isolation.

Abstract: A class of blue emitting materials, that, when placed in EL devices with an emitter layer and a hole transporter layer, provide EL devices that emit white light. The blue-emitting material has a non-polymeric molecular structure that comprises a five or six-membered heterocyclic moiety selected from the groups consisting of oxazole, imidazole, quinoline and pyrazine with at least three substituents pendant thereto. The blue-emitting materials of the present invention have certain characteristics that allow them to be formed into films with advantageous properties. The films formed from these materials are amorphous (i.e they have a crystal size less than about 1000 .ANG.). The thickness of the films of the blue-emitting material is less than 600 .ANG. in the devices of the present invention.