Patents by Inventor Rebecca L. Nichols
Rebecca L. Nichols has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7682637Abstract: A product made by a process which results in compositions enriched in total phenols includes purification steps not involving the addition of bisulfite ions. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols, total phenol concentration >12% and exhibiting in vitro COX-2 inhibitory activity enhanced by a factor of at least 2.5 over a standard aspirin dose of 660 ?g/mL.Type: GrantFiled: August 7, 2007Date of Patent: March 23, 2010Assignee: Phenolics, LLCInventors: Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, David T. Bailey, Rebecca L. Nichols, F. Joseph Daugherty, Delano R. Freeberg
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Publication number: 20080207770Abstract: Provided are processes for the preparation of compositions enriched in phenolic compounds from a crude plant extract. One process includes a novel column purification step using a polymer resin that releasably adsorbs the phenolic compounds but does not retain polar non-phenolic compounds, wherein the resin comprises aromatic rings substituted with one or more electron-withdrawing groups. This invention also includes compositions enriched in phenolic compounds. This invention encompasses methods of using the phenolic-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease. The compositions are also useful as meat additives to inhibit food-borne pathogens.Type: ApplicationFiled: November 30, 2007Publication date: August 28, 2008Applicant: PHENOLICS, LLCInventors: Gerald T. GOURDIN, Steven L. Richheimer, Michael S. Tempesta, David T. Bailey, Rebecca L. Nichols, F. Joseph Daugherty, Delano R. Freeberg
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Publication number: 20080199548Abstract: A product made by a process which results in compositions enriched in total phenols includes purification steps not involving the addition of bisulfite ions. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols, total phenol concentration >12% and exhibiting in vitro COX-2 inhibitory activity enhanced by a factor of at least 2.5 over a standard aspirin dose of 660 ?g/mL.Type: ApplicationFiled: August 7, 2007Publication date: August 21, 2008Applicant: PHENOLICS, LLCInventors: Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, David T. Bailey, Rebecca L. Nichols, F. Joseph Daugherty, Delano R. Freeberg
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Patent number: 7306815Abstract: Provided are processes for the preparation of compositions enriched in phenolic compounds from a crude plant extract. One process includes a novel column purification step using a polymer resin that releasably adsorbs the phenolic compounds but does not retain polar non-phenolic compounds, wherein the resin comprises aromatic rings substituted with one or more electron-withdrawing groups. This invention also includes compositions enriched in phenolic compounds. This invention encompasses methods of using the phenolic-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease. The compositions are also useful as meat additives to inhibit food-borne pathogens.Type: GrantFiled: January 23, 2004Date of Patent: December 11, 2007Assignee: Phenolics, LLCInventors: Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, David T. Bailey, Rebecca L. Nichols, F. Joseph Daugherty, Delano R. Freeberg
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Patent number: 7141611Abstract: This invention provides an isolated mixture of higher molecular weight primary aliphatic alcohols having 20, 22, 24, 26, 27, 28, 30, 32 and 34 carbon atoms and having enhanced purity. This invention also provides a process for obtaining the alcohol mixture by extracting a natural product with organic solvents with or without saponification of the natural product. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering total cholesterol and LDL-cholesterol and increasing HDL-cholesterol levels and therefore is effective in treating hypercholesterolemia. The composition may be used to reduce the risk of coronary heart disease, to inhibit the atherosclerotic process (platelet hyperaggregability, ischemia and thrombosis), and can be used as an anti-inflammatory and anti-thrombotic agent. The composition also possesses neurotrophic properties and is useful for improving male sexual activity.Type: GrantFiled: July 18, 2003Date of Patent: November 28, 2006Assignee: WyethInventors: William R. Gamble, Zhengjie Liu, David T. Bailey, Pedro P. Perez, Dean P. Stull, Steven L. Richheimer, Rebecca L. Nichols, Rod Lenoble
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Patent number: 6960360Abstract: This invention provides a process for the preparation of compositions enriched in total phenols from a crude plant extract. The process includes a novel column purification step using a brominated polystyrene resin. This invention also includes compositions enriched in total phenols. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols and having HPLC chromatograms substantially as set forth in FIGS. 10-13. This invention encompasses methods of using the total phenol-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease.Type: GrantFiled: November 22, 2002Date of Patent: November 1, 2005Assignee: Phenolics, LLCInventors: Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, David T. Bailey, Rebecca L. Nichols, F. Joseph Daugherty, Delano R. Freeberg
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Publication number: 20040019119Abstract: This invention provides an isolated mixture of higher molecular weight primary aliphatic alcohols having 20, 22, 24, 26, 27, 28, 30, 32 and 34 carbon atoms and having enhanced purity. This invention also provides a process for obtaining the alcohol mixture by extracting a natural product with organic solvents with or without saponification of the natural product. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering total cholesterol and LDL-cholesterol and increasing HDL-cholesterol levels and therefore is effective in treating hypercholesterolemia. The composition may be used to reduce the risk of coronary heart disease, to inhibit the atherosclerotic process (platelet hyperaggregability, ischemia and thrombosis), and can be used as an anti-inflammatory and anti-thrombotic agent. The composition also possesses neurotrophic properties and is useful for improving male sexual activity.Type: ApplicationFiled: July 18, 2003Publication date: January 29, 2004Inventors: William R. Gamble, Zhengjie Liu, David T. Bailey, Pedro P. Perez, Dean P. Stull, Steven L. Richheimer, Rebecca L. Nichols, Rod Lenoble
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Publication number: 20030149252Abstract: This invention provides a process for the preparation of compositions enriched in total phenols from a crude plant extract. The process includes a novel column purification step using a brominated polystyrene resin. This invention also includes compositions enriched in total phenols. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols and having HPLC chromatograms substantially as set forth in FIGS. 10-13. This invention encompasses methods of using the total phenol-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease.Type: ApplicationFiled: November 22, 2002Publication date: August 7, 2003Inventors: Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, David T. Bailey, Rebecca L. Nichols, F. Joseph Daugherty, Delano R. Freeberg
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Publication number: 20030138537Abstract: The present invention provides an improved process for preparing a water-soluble extract containing one or more naturally occurring antioxidants (from plant materials from the Labiatae family. The process produces an extract that is essentially odorless, flavorless and colorless when used at a concentration between about 5 and 1000 ppm.Type: ApplicationFiled: December 19, 2001Publication date: July 24, 2003Inventors: David T. Bailey, Rebecca L. Nichols, Steven L. Richheimer
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Patent number: 6596776Abstract: The present invention relates to a naturally obtained mixture of higher molecular weight primary aliphatic alcohols which contain 20 to 34 carbon atoms. This invention also relates to the process for obtaining the alcohol mixture by extraction and purification with organic solvents from a natural product, such as beeswax with and without saponification of the natural product. The alcohol mixture obtained from beeswax has enhanced purity and contains a mixture of alcohols having 20, 22, 24, 26, 27, 28, 30, 32 and 34 carbon atoms. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering cholesterol and LDL-cholesterol and increasing HDL-cholesterol levels so that it is effective in treating hypercholesterolemia.Type: GrantFiled: April 25, 2002Date of Patent: July 22, 2003Assignee: Hauser, Inc.Inventors: William R. Gamble, Zhengjie Liu, David T. Bailey, Pedro P. Perez, Dean P. Stull, Steven L. Richheimer, Rebecca L. Nichols, Rod Lenoble
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Publication number: 20030096876Abstract: The present invention relates to a naturally obtained mixture of higher molecular weight primary aliphatic alcohols which contain 20 to 34 carbon atoms. This invention also relates to the process for obtaining the alcohol mixture by extraction and purification with organic solvents from a natural product, such as beeswax with and without saponification of the natural product. The alcohol mixture obtained from beeswax has enhanced purity and contains a mixture of alcohols having 20, 22, 24, 26, 27, 28, 30, 32 and 34 carbon atoms. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering cholesterol and LDL-cholesterol and increasing HDL-cholesterol levels so that it is effective in treating hypercholesterolemia.Type: ApplicationFiled: April 25, 2002Publication date: May 22, 2003Inventors: William R. Gamble, Zhengjie Liu, David T. Bailey, Pedro P. Perez, Dean P. Stull, Steven L. Richheimer, Rebecca L. Nichols, Rod Lenoble
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Publication number: 20020099099Abstract: The present invention relates to a naturally obtained mixture of higher molecular weight primary aliphatic alcohols which contain 20 to 34 carbon atoms. This invention also relates to the process for obtaining the alcohol mixture by extraction and purification with organic solvents from a natural product, such as beeswax with and without saponification of the natural product. The alcohol mixture obtained from beeswax has enhanced purity and contains a mixture of alcohols having 20, 22, 24, 26, 27, 28, 30, 32 and 34 carbon atoms. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering cholesterol levels so that it is effective in treating hypercholesterolemia.Type: ApplicationFiled: September 7, 2001Publication date: July 25, 2002Inventors: William R. Gamble, Zhengjie Liu, David T. Bailey, Pedro P. Perez, Dean P. Stull, Steven L. Richheimer, Rebecca L. Nichols, Rod Lenoble
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Patent number: 6399579Abstract: Compositions for maintaining normal sexual function and treating sexual dysfunction in males and females comprising at least 15% by weight icariside I or at least 3.5% by weight anhydroicaritin, derived from extracts of plants belonging the Epimedium genus, and methods for preparing the same, are provided. The methods comprise subjecting an Epimedium extract to mild acid hydrolysis. Methods for maintaining normal sexual function and treating sexual dysfunction in both males and females are also provided, comprising oral administration of an effective amount of a novel composition of this invention comprising at least 15% by weight icariside I or at least 3.5% by weight anhydroicaritin.Type: GrantFiled: August 15, 2000Date of Patent: June 4, 2002Assignee: Hauser, Inc.Inventors: Rod Lenoble, Steven L. Richheimer, David Bailey, Coralee G. Mannila, Rebecca L. Nichols