Abstract: Provided herein are methods and corresponding compounds for treating fibrotic disease by administering to a subject a compound of Formula I or pharmaceutically acceptable salt thereof, which inhibits phosphorylation of Smad2/3, according to Phospho-Smad2/3 Inhibition Assay, including compounds that are active according to MAPK p38 Activation Assay; or a compound of Formula II or III. Also provided are methods and corresponding compounds for treating cancers, inflammatory diseases, rasopathies and autoimmune leukoproliferative disorders.

Abstract: A tuned mass damper (TMD) system in combination with a floating offshore wind turbine (FOWT) platform includes a barge type FOWT platform having a hull configured to have a wind turbine tower mounted thereon. A TMD system is mounted in the hull and has a first TMD configured to operate at a first frequency, and a second TMD configured to operate at a second frequency different than the first frequency.

Abstract: A microscope apparatus and a microscopic method that uses the microscope apparatus for examining a sample or a specimen, such as but not limited to a tissue sample or a tissue specimen, includes a convex curved distal exit window at a distal end of the microscope apparatus. Due to the presence of the convex curved distal exit window, the microscope apparatus may readily make contact with the sample or the specimen absent trauma to the sample or the specimen. In addition, an index of refraction matched immersion fluid may be used for focusing the microscope apparatus by hydraulic movement of an objective optic lens assembly interior to the distal exit window with respect to the distal exit window. The convex curved distal exit window and index of refraction matched immersion fluid characteristics may be extended to various microscope apparatuses and methods, and in particular medical microscope apparatuses and methods.

Abstract: A microscope apparatus and a microscopic method that uses the microscope apparatus for examining a sample or a specimen, such as but not limited to a tissue sample or a tissue specimen, includes a convex curved distal exit window at a distal end of the microscope apparatus. Due to the presence of the convex curved distal exit window, the microscope apparatus may readily make contact with the sample or the specimen absent trauma to the sample or the specimen. In addition, an index of refraction matched immersion fluid may be used for focusing the microscope apparatus by hydraulic movement of an objective optic lens assembly interior to the distal exit window with respect to the distal exit window. The convex curved distal exit window and index of refraction matched immersion fluid characteristics may be extended to various microscope apparatuses and methods, and in particular medical microscope apparatuses and methods.

Abstract: The present invention is directed to a method of applying radiation through an optical fiber for detecting disease within a plant or animal or other penetrable tissue, or imaging a particular tissue of a plant or animal. In addition, fluorescence and nonlinear scattering signals can be detected and localized within a subject by such application of radiation through an optical fiber. The radiation is effective to promote simultaneous multiphoton excitation. The optical fibers are used alone to examine internal regions of tissue, in conjunction with an optical biopsy needle to evaluate sub-surface tissue, or with an endoscope to evaluate tissue within body cavities. The present invention also relates to a device for coupling in radiation from an ultrashort mode-locked laser into the beam path of a microscope.

Abstract: This invention provides a composite article comprising a support member, a controlled release material coated on the support member, and an inorganic pigment coated onto the controlled release material. In another aspect, this invention provides a method of making the same. The controlled release material comprises a first component and optionally a second component which are independently one of an organic material and an inorganic material. The composite article, which can be a donor substrate, is useful in thermal imaging.

Abstract: An imaging film donor sheet comprising a substrate, a controlled release/adhesive layer and a vapor-deposited colorant layer, wherein the deposited colorant layer exhibit a discernible microstructure, preferably a columnar microstructure. A matching receptor sheet is provided. A method of preparing the donor sheet as well as a method of imaging is provided.

Abstract: An imaging film donor sheet comprising a substrate, a controlled release/adhesive layer and a vapor-deposited colorant layer, wherein the deposited colorant layer exhibit a discernible microstructure, preferably a columnar microstructure. A matching receptor sheet is provided. A method of preparing the donor sheet as well as a method of imaging is provided.