Patents by Inventor Rebecca McDonald
Rebecca McDonald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240148885Abstract: The present disclosure provides, in one aspect, bifunctional compounds that can be used to promote or enhance degradation of an extracellular or cell surface protein. In certain embodiments, the extracellular protein mediates a disease and/or disorder in a subject, and treatment or management of the disease and/or disorder requires degradation, removal, and/or reduction in concentration of the protein in the subject. In some embodiments, the disease and/or disorder is a neurological disease and/or disorder. Thus, in certain embodiments, administration of a compound of the disclosure to the subject removes or reduces the amount of the extracellular or cell surface protein in the brain, thus treating, ameliorating, or preventing the disease and/or disorder.Type: ApplicationFiled: February 22, 2022Publication date: May 9, 2024Inventors: David Spiegel, Rebecca Howell, David McDonald
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Publication number: 20240075312Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Biological effects may include upregulating and downregulating inflammatory immune response molecules within a target tissue. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths.Type: ApplicationFiled: November 14, 2023Publication date: March 7, 2024Inventors: Adam Cockrell, Jacob Kocher, David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Rebecca McDonald
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Publication number: 20240024699Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: October 4, 2023Publication date: January 25, 2024Inventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald, James Michael Lay
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Publication number: 20230302293Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an antiinflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: May 23, 2023Publication date: September 28, 2023Inventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald, James Michael Lay
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Patent number: 11752359Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: GrantFiled: August 24, 2021Date of Patent: September 12, 2023Assignee: KNOW Bio, LLCInventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald, James Michael Lay
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Patent number: 11712578Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: GrantFiled: August 24, 2021Date of Patent: August 1, 2023Assignee: KNOW Bio, LLCInventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald, James Michael Lay
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Patent number: 11684798Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: GrantFiled: August 24, 2021Date of Patent: June 27, 2023Assignee: KNOW Bio, LLCInventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald, James Michael Lay
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Publication number: 20220023660Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: August 24, 2021Publication date: January 27, 2022Inventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald
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Publication number: 20210379400Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: August 24, 2021Publication date: December 9, 2021Inventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald
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Patent number: 11147984Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: GrantFiled: December 10, 2020Date of Patent: October 19, 2021Assignee: KNOW Bio, LLCInventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald
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Publication number: 20210290970Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: January 29, 2021Publication date: September 23, 2021Inventors: F. Neal Hunter, Antony Paul van de Ven, Nathan Stasko, David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Adam Cockrell, Rebecca McDonald
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Publication number: 20210290971Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Biological effects may include upregulating and downregulating inflammatory immune response molecules within a target tissue. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths.Type: ApplicationFiled: February 11, 2021Publication date: September 23, 2021Inventors: Adam Cockrell, Jacob Kocher, David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Rebecca McDonald
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Publication number: 20210290974Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: December 10, 2020Publication date: September 23, 2021Inventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald
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Publication number: 20210290975Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: January 29, 2021Publication date: September 23, 2021Inventors: F. Neal Hunter, Antony Paul van de Ven, Nathan Stasko, David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Adam Cockrell, Rebecca McDonald
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Publication number: 20210138259Abstract: Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: January 13, 2021Publication date: May 13, 2021Inventors: Nathan Stasko, David T. Emerson, Adam Cockrell, F. Neal Hunter, Michael John Bergmann, Rebecca McDonald, Nicholas William Medendorp, JR., Gerald H. Negley, Katelyn P. Reighard
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Publication number: 20210128936Abstract: Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: January 13, 2021Publication date: May 6, 2021Inventors: Nathan Stasko, David T. Emerson, Adam Cockrell, F. Neal Hunter, Michael John Bergmann, Rebecca McDonald, Nicholas William Medendorp, JR., Gerald H. Negley, Katelyn P. Reighard
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Publication number: 20210128937Abstract: Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: January 13, 2021Publication date: May 6, 2021Inventors: Nathan Stasko, David T. Emerson, Adam Cockrell, F. Neal Hunter, Michael John Bergmann, Rebecca McDonald, Nicholas William Medendorp, JR., Gerald H. Negley, Katelyn P. Reighard
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Publication number: 20210128935Abstract: Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: December 10, 2020Publication date: May 6, 2021Inventors: Nathan Stasko, David T. Emerson, Adam Cockrell, F. Neal Hunter, Michael John Bergmann, Rebecca McDonald, Nicholas William Medendorp, JR., Gerald H. Negley, Katelyn P. Reighard
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Publication number: 20210128938Abstract: Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.Type: ApplicationFiled: January 13, 2021Publication date: May 6, 2021Inventors: Nathan Stasko, David T. Emerson, Adam Cockrell, F. Neal Hunter, Michael John Bergmann, Rebecca McDonald, Nicholas William Medendorp, JR., Gerald H. Negley, Katelyn P. Reighard