Abstract: The present invention relates to trivalent, bispecific antibodies, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.

Abstract: A laminate includes a first glass article having a first thickness, a first annealing point (TA1), and a first softening point (TS1), a second glass article having a second thickness, a second annealing point (TA2), and a second softening point (TS2), and an interlayer disposed between the first glass article and the second glass article. The first thickness is greater than the second thickness, the second annealing point (TA2) is less than or equal to the first annealing point (TA1), and the second softening point (TS2) is greater than the first softening point (TS1).

Abstract: The present disclosure is directed to alcohol and amine containing exatecan derivatives, and pharmaceutically acceptable salts or solvates thereof, comprising a structure of formula I: wherein X is defined in the disclosure. The disclosure is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of cancers and/or tumors.

Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, X1, X2, X3, X4, integer a and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: Disclosed is a substance which down-regulates the activity of a MAST gene, or the activity of a transcription or translation product of a MAST gene, for use in the prevent and/or treatment of an inflammatory skin condition in a mammalian subject.

Abstract: Implementations of the present application relate to caller previews for video calls. In some implementations, a method includes sending, by a caller device, a call request to a callee device and determining an identifier associated with the callee device. The method determines whether the identifier is associated with an address book of the caller device, and/or is in an outgoing call record of the caller device. An acknowledgment is received from callee device, and, upon receipt of the acknowledgment, a connection is established with the callee device. Based on determining that the identifier is associated with the address book and/or in the outgoing call record, at least a portion of a caller video is transmitted over the connection with the callee device. The caller video is transmitted prior to receipt of an acceptance of the call request from the callee device.

Abstract: Implementations of the present application relate to caller previews for video calls. In some implementations, a method includes sending, by a caller device, a call request to a callee device and determining an identifier associated with the callee device. The method determines whether the identifier is associated with an address book of the caller device, and/or is in an outgoing call record of the caller device. An acknowledgment is received from callee device, and, upon receipt of the acknowledgment, a connection is established with the callee device. Based on determining that the identifier is associated with the address book and/or in the outgoing call record, at least a portion of a caller video is transmitted over the connection with the callee device. The caller video is transmitted prior to receipt of an acceptance of the call request from the callee device.

Abstract: Implementations of the present application relate to caller previews for video calls. In some implementations, a method includes sending, by a caller device, a call request to a callee device and determining an identifier associated with the callee device. The method determines whether the identifier is associated with an address book of the caller device, and/or is in an outgoing call record of the caller device. An acknowledgment is received from callee device, and, upon receipt of the acknowledgment, a connection is established with the callee device. Based on determining that the identifier is associated with the address book and/or in the outgoing call record, at least a portion of a caller video is transmitted over the connection with the callee device. The caller video is transmitted prior to receipt of an acceptance of the call request from the callee device.

Abstract: This invention relates to the modification of the amino acid sequence of an immunoglobulin molecule at certain key positions within regions of the VH and VL FR and CDR3 domains and/or the CH1 domain which are prone to aggregation. Immunoglobulins modified as described may display improved manufacturability, for example, reduced aggregation propensity and/or increased production levels.

Abstract: This invention relates to the modification of the amino acid sequence of an immunoglobulin molecule at certain key positions within regions of the VH and VL FR and CDR3 domains and/or the CH1 domain which are prone to aggregation. Immunoglobulins modified as described may display improved manufacturability, for example, reduced aggregation propensity and/or increased production levels.

Abstract: This invention relates to the modification of the amino acid sequence of an immunoglobulin molecule at certain key positions within regions of the VH and VL FR and CDR3 domains and/or the CH1 domain which are prone to aggregation. Immunoglobulins modified as described may display improved manufacturability, for example, reduced aggregation propensity and/or increased production levels.

Abstract: This invention relates to the modification of the amino acid sequence of an immunoglobulin molecule at certain key positions within regions of the VH and VL FR and CDR3 domains and/or the CH1 domain which are prone to aggregation. Immunoglobulins modified as described may display improved manufacturability, for example, reduced aggregation propensity and/or increased production levels.