Patents by Inventor Rebecka Ingrid Camilla Ottosson

Rebecka Ingrid Camilla Ottosson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for in vitro molecular evolution of protein function involving the use of exonuclease enzyme and two populations of parent polynucleotide sequence
    Patent number: 7153655
    Abstract: The present invention relates to a method for in vitro evolution of protein function. In particular, the method relates to the shuffling of nucleotide segments obtained from exonuclease digestion. The present inventors have shown that polynucleotide fragments derived from a parent polynucleotide sequence digested with an exonuclease can be combined to generate a polynucleotide sequence which encodes for a polypeptide having desired characteristics. This method may be usefully applied to the generation of new proteins (e.g., antibodies and enzymes) or parts thereof having modified characteristics as compared to the parent protein.
    Type: Grant
    Filed: December 17, 2002
    Date of Patent: December 26, 2006
    Assignee: Alligator Bioscience AB
    Inventors: Carl Arne Krister Borrebaeck, Ann-Christin Malmborg-Hager, Christina Furebring, Ulf Hans Eskil Soderlind, Rebecka Ingrid Camilla Ottosson
  • Method for in vitro molecular evolution of protein function
    Publication number: 20030148353
    Abstract: The present invention relates to a method for in vitro evolution of protein function. In particular, the method relates to the shuffling of nucleotide segments obtained from exonuclease digestion. The present inventors have shown that polynucleotide fragments derived from a parent polynucleotide sequence digested with an exonuclease can be combined to generate a polynucleotide sequence which encodes for a polypeptide having desired characteristics. This method may be usefully applied to the generation of new proteins (e.g., antibodies and enzymes) or parts thereof having modified characteristics as compared to the parent protein.
    Type: Application
    Filed: December 17, 2002
    Publication date: August 7, 2003
    Inventors: Carl Arne Krister Borrebaeck, Ann-Christin Malmborg-Hager, Christina Furebring, Ulf Hans Eskil Soderlind, Rebecka Ingrid Camilla Ottosson
  • Method for in vitro molecular evolution of protein function
    Patent number: 6495321
    Abstract: The present invention relates to a method for in vitro evolution of protein function. In particular, the method relates to the shuffling of nucleotide segments obtained from exonuclease digestion. The present inventors have shown that polynucleotide fragments derived from a parent polynucleotide sequence digested with an exonuclease can be combined to generate a polynucleofide sequence which encodes for a polypeptide having desired characteristics. This method may be usefully applied to the generation of new antibodies or parts thereof having modified characteristics as compared to the parent antibody.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: December 17, 2002
    Assignee: BioInvent International AB
    Inventors: Carl Arne Krister Borrebaeck, Ulf Hans Eskil Soderlind, Rebecka Ingrid Camilla Ottosson
  • Method for in vitro molecular evolution of protein function using exonuclease and amplification
    Patent number: 6159690
    Abstract: The present invention relates to a method for in vitro evolution of protein function. In particular, the method relates to the shuffling of nucleotide segments obtained from exonuclease digestion. The present inventors have shown that polynucleotide fragments derived from a parent polynucleotide sequence digested with an exonuclease can be combined to generate a polynucleotide sequence which encodes for a polypeptide having desired characteristics. This method may be usefully applied to the generation of new antibodies or parts thereof having modified characteristics as compared to the parent antibody.
    Type: Grant
    Filed: June 16, 1998
    Date of Patent: December 12, 2000
    Assignee: BioInvent International AB
    Inventors: Carl Arne Krister Borrebaeck, Ulf Hans Eskil Soderlind, Rebecka Ingrid Camilla Ottosson