Patents by Inventor Reena Chawla

Reena Chawla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecule antagonists of sumo related modification of CRMP2 and uses thereof
    Patent number: 11208397
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a piperidinyl-benzoimidazole structure which function as antagonists of small ubiquitin like modifier (SUMO) related modification (SUMOylation) of collapsin response mediator protein 2 (CRMP2), and their use as therapeutics for the treatment of voltage gated sodium channel 1.7 (Nav1.7) related itch, anosmia, migraine event, and/or pain (e.g., neuropathic pain).
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: December 28, 2021
    Assignee: Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: May Khanna, Rajesh Khanna, Vijay Gokhale, Reena Chawla
  • CRMP2 sumoylation inhibitors and uses thereof
    Patent number: 11020391
    Abstract: The present invention provides compounds that can modulate the amount of Nav1.7 protein, a key protein in pain signaling, that is present in the cellular surface and methods for using such compounds. In particular, compounds of the invention modulate the amount of Nav1.7 protein on the cellular surface by modulating SUMOylation of CRMP2. Thus, compounds of the invention can be used to treat various clinical conditions associated with the presence and/or activation of Nav1.7 protein on the cellular surface and/or SUMOylation of CRMP2.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: June 1, 2021
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: May Khanna, Rajesh Khanna, Vijay Gokhale, Reena Chawla
  • SMALL MOLECULE ANTAGONISTS OF SUMO RELATED MODIFICATION OF CRMP2 AND USES THEREOF
    Publication number: 20200277271
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a piperidinyl-benzoimidazole structure which function as antagonists of small ubiquitin like modifier (SUMO) related modification (SUMOylation) of collapsin response mediator protein 2 (CRMP2), and their use as therapeutics for the treatment of voltage gated sodium channel 1.7 (Nav1.7) related itch, anosmia, migraine event, and/or pain (e.g., neuropathic pain).
    Type: Application
    Filed: February 2, 2018
    Publication date: September 3, 2020
    Inventors: May KHANNA, Rajesh KHANNA, Vijay GOKHALE, Reena CHAWLA
  • Indoline derivatives and method for using and producing the same
    Patent number: 10654802
    Abstract: The present invention relates to a compound of the formula: where n, R1 and R2 are those defined herein. The present invention also relates to use of a compound of Formula 1 in treating a clinical condition associated with fibrotic disorder.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: May 19, 2020
    Assignee: Arizona Board of Regents on Behalf of the Unversit
    Inventors: Louise Hecker, Vijay Gokhale, Reena Chawla
  • CRMP2 SUMOYLATION INHIBITORS AND USES THEREOF
    Publication number: 20200093822
    Abstract: The present invention provides compounds that can modulate the amount of Nav1.7 protein, a key protein in pain signaling, that is present in the cellular surface and methods for using such compounds. In particular, compounds of the invention modulate the amount of Nav1.7 protein on the cellular surface by modulating SUMOylation of CRMP2. Thus, compounds of the invention can be used to treat various clinical conditions associated with the presence and/or activation of Nav1.7 protein on the cellular surface and/or SUMOylation of CRMP2.
    Type: Application
    Filed: October 8, 2019
    Publication date: March 26, 2020
    Inventors: May Khanna, Rajesh Khanna, Vijay Gokhale, Reena Chawla
  • CRMP2 SUMOylation inhibitors and uses thereof
    Patent number: 10441586
    Abstract: The present invention provides compounds that can modulate the amount of Nav 1.7 protein, a key protein in pain signaling, that is present in the cellular surface and methods for using such compounds. In particular, compounds of the invention modulate the amount of Nav 1.7 protein on the cellular surface by modulating SUMOylation of CRMP2. Thus, compounds of the invention can be used to treat various clinical conditions associated with the presence and/or activation of Nav 1.7 protein on the cellular surface and/or SUMOylation of CRMP2.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: October 15, 2019
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: May Khanna, Rajesh Khanna, Vijay Gokhale, Reena Chawla
  • INDOLINE DERIVATIVES AND METHOD FOR USING AND PRODUCING THE SAME
    Publication number: 20190135746
    Abstract: The present invention relates to a compound of the formula: where n, R and R are those defined herein. The present invention also relates to use of a compound of Formula 1 in treating a clinical condition associated with fibrotic disorder.
    Type: Application
    Filed: July 7, 2017
    Publication date: May 9, 2019
    Inventors: Louise HECKER, Vijay GOKHALE, Reena CHAWLA
  • CRMP2 SUMOYLATION INHIBITORS AND USES THEREOF
    Publication number: 20180289700
    Abstract: The present invention provides compounds that can modulate the amount of Nav 1.7 protein, a key protein in pain signaling, that is present in the cellular surface and methods for using such compounds. In particular, compounds of the invention modulate the amount of Nav 1.7 protein on the cellular surface by modulating SUMOylation of CRMP2. Thus, compounds of the invention can be used to treat various clinical conditions associated with the presence and/or activation of Nav 1.7 protein on the cellular surface and/or SUMOylation of CRMP2.
    Type: Application
    Filed: October 7, 2016
    Publication date: October 11, 2018
    Applicant: Arizona Board of Regents on Behalf of the University of Arzona
    Inventors: May Khanna, Rajesh Khanna, Vijay Gokhale, Reena Chawla