Patents by Inventor Regina BLEUL

Regina BLEUL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240033220
    Abstract: A method and a device for producing a liquid containing liposomes is presented. The method comprises the conduction of a first liquid and a second liquid into a micromixer and to the output of the micromixer by gas pressure from at least one source of gas. The total flow rate of the liquids is adjusted in such a way that the total flow rate at the output of the micromixer is at least 10 mL/min. This allows the production of liquids, which contain liposomes having a narrow size distribution, on an industrial scale in a simple and reproducible manner. The embodiments also include a liquid containing liposomes having a narrow size distribution and to uses thereof.
    Type: Application
    Filed: May 19, 2023
    Publication date: February 1, 2024
    Applicant: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
    Inventors: Regina Bleul, Raphael Thiermann
  • Patent number: 11361886
    Abstract: The present invention relates to magnetic single-core nanoparticles, in particular stable dispersible magnetic single-core nanoparticles (e.g. single-core magnetite nanoparticles) having a diameter between 20 and 200 nm in varied morphology, and the continuous aqueous synthesis thereof, in particular using micromixers. The method is simple, quick and cost-effective to perform and is carried out without organic solvents. The single-core nanoparticles produced by the method form stable dispersions in aqueous media, i.e. not having a tendency to assemble or aggregate. In addition, the method offers the possibility of producing anisotropic, super-paramagnetic, plate-shaped nanoparticles which, due to their shape anisotrophy, are extremely suitable for use in polymer matrices for magnet field-controlled release of active substances.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: June 14, 2022
    Assignee: Fraunhofer-Gesellschaft zurförderung der angewandten Forschung e.V.
    Inventors: Regina Bleul, Raphael Thiermann
  • Publication number: 20180240577
    Abstract: The present invention relates to magnetic single-core nanoparticles, in particular stable dispersible magnetic single-core nanoparticles (e.g. single-core magnetite nanoparticles) having a diameter between 20 and 200 nm in varied morphology, and the continuous aqueous synthesis thereof, in particular using micromixers. The method is simple, quick and cost-effective to perform and is carried out without organic solvents. The single-core nanoparticles produced by the method form stable dispersions in aqueous media, i.e. not having a tendency to assemble or aggregate. In addition, the method offers the possibility of producing anisotropic, super-paramagnetic, plate-shaped nanoparticles which, due to their shape anisotrophy, are extremely suitable for use in polymer matrices for magnet field-controlled release of active substances.
    Type: Application
    Filed: August 5, 2016
    Publication date: August 23, 2018
    Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
    Inventors: Regina BLEUL, Raphael THIERMANN