Patents by Inventor Regina Zhuk

Regina Zhuk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BENZOTHIAZOLYL THIENOPYRIDINE DERIVATIVES AND USES THEREOF
    Publication number: 20100298370
    Abstract: Novel benzothiazolyl thienopyridine compounds are provided and pharmaceutical compositions comprising benzothiazolyl thienopyridine compounds. The benzothiazolyl thienopyridine compounds are capable of inhibiting the interactions between vascular endothelial growth factor (VEGF) and heparan sulfate glycosaminoglycans (HS-GAGs), and are useful for prevention or treatment of diseases and disorders such as inflammation, autoimmune diseases and cancer.
    Type: Application
    Filed: August 14, 2007
    Publication date: November 25, 2010
    Inventors: Paul Gregor, Regina Zhuk, Nicolas Harris, Juraj Koppel
  • Pharmaceutical compositions comprising thieno[2,3-c]pyridine derivatives and use thereof
    Patent number: 7365080
    Abstract: The present invention provides thieno[2,3-C]pyridine derivatives, pharmaceutical compositions comprising the thieno[2,3-C]pyridine derivatives, and methods of use thereof. The compounds capable of inhibiting glycosaminoglycan (GAG) interactions with effector cell adhesion molecules (ECAM) are useful for treating diseases and disorders mediated by GAG-ECAMs interactions, particularly inflammatory and autoimmune diseases, viral diseases, cancer, and amyloid disorders.
    Type: Grant
    Filed: February 5, 2004
    Date of Patent: April 29, 2008
    Assignee: Rimonyx Pharmaceuticals Ltd.
    Inventors: Paul Gregor, Nicholas Harris, Juraj Koppel, Regina Zhuk
  • Pharmaceutical compositions comprising anti-inflammatory quinazolinecarboxamide derivatives
    Publication number: 20070191400
    Abstract: The present invention provides pharmaceutical compositions comprising quinazolinecarboxamide derivative, and certain novel quinazolinecarboxamide derivatives capable of inhibiting heparan sulfate-glycosaminoglycan (HS-GAGs) interactions with L-selectin, and useful in the prevention or treatment of various diseases, disorders and conditions mediated by HS-GAGs, particularly inflammatory and autoimmune diseases, viral diseases, cancer, and amyloid disorders.
    Type: Application
    Filed: March 24, 2005
    Publication date: August 16, 2007
    Applicant: Rimonyx Pharmaceuticals Ltd.
    Inventors: Paul Gregor, Nicholas Harris, Juraj Koppel, Regina Zhuk
  • Screening of anti-viral drugs and pharmaceuticals composition containing thiazolidinone derivatives
    Publication number: 20070179137
    Abstract: The present invention relates to a method of screening for small organic molecules that directly inhibit the interaction of glycosaminoglycans (GAGs) with GAG-binding viral proteins (GBVPs), which comprises contacting a GAG with an GBVP in the presence of at least one candidate compound; and measuring the amount of the GAG bound to the GBVP or the amount of the GBVP bound to the GAG, wherein a significant decrease in GAG-GBVP binding as compared to GAG-GBVP binding in the absence of the candidate compound, identifies said compound as inhibitor of the GAG-GBVP interaction. The invention further provides pharmaceutical compositions comprising certain 2-thioxo-thiazolidinone derivatives, particularly useful against virus infections.
    Type: Application
    Filed: March 24, 2005
    Publication date: August 2, 2007
    Applicant: RIMONYX PHARMACEUTICALS LTD.
    Inventors: Paul Gregor, Nicholas Harris, Regina Zhuk
  • Pharmaceutical compositions comprising thieno[2,3-c]pyridine derivatives and use thereof
    Publication number: 20060135529
    Abstract: The present invention provides thieno[2,3-C]pyridine derivatives, pharmaceutical compositions comprising the thieno[2,3-C]pyridine derivatives, and methods of use thereof. The compounds capable of inhibiting glycosaminoglycan (GAG) interactions with effector cell adhesion molecules (ECAM) are useful for treating diseases and disorders mediated by GAG-ECAMs interactions, particularly inflammatory and autoimmune diseases, viral diseases, cancer, and amyloid disorders.
    Type: Application
    Filed: February 5, 2004
    Publication date: June 22, 2006
    Applicant: Rimonyx Pharmaceuticals Ltd
    Inventors: Paul Gregor, Nicholas Harris, Juraj Koppel, Regina Zhuk
  • 9-substituted guanines
    Patent number: 4916225
    Abstract: Novel compounds, 9-substituted guanines, with the following general formula ##STR1## where R' is acetyl;R" is 2-tetrahydrofuryl or 2-tetrahydropyranyl.The proposed compounds have antiviral activity.
    Type: Grant
    Filed: July 14, 1988
    Date of Patent: April 10, 1990
    Assignees: Institut Organicheskogo Sinteza Akademii nauk Latviiskoi SSR, Belorussky Nauchno-Issledovatelsky Institute Epidemiologii i Mikrobiologii
    Inventors: Regina A. Zhuk, Marger J. Lidak, Marina A. Madre, Veniamin I. Votyakov, Olga T. Andreeva, Evgeny I. Boreko, Ljudmila V. Korobchenko, Vyacheslav A. Rusyaev, Olga I. Starkova
  • 1-(5-Fluoruracil-1)-2,5-di-O-acetyl-.beta.-D-glucofuranurono-6,3-lactone
    Patent number: 4232149
    Abstract: 1-(5-Fluoruacil-1)-2,5-di-O-acetyl-.beta.-D-glucofuranurono-6,3-lactone has the formula ##STR1## Said substance has a marked antiblastic action. The substance is less toxic compared with the known preparation of similar action.
    Type: Grant
    Filed: July 27, 1978
    Date of Patent: November 4, 1980
    Inventors: Ruta A. Paegle, Marger J. Lidaka, Regina A. Zhuk, Juris A. Maurinsh, Aina A. Zidermane, Marite K. Kilevitsa