Patents by Inventor Regis J. O'Keefe

Regis J. O'Keefe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA methyltransferases for the treatment and prevention of arthritis
    Patent number: 10123983
    Abstract: The present disclosure is directed to compositions and methods for treating osteoarthritis comprising increasing the expression of Dnmt3b and/or inhibiting aminobutyrate aminotransferase.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: November 13, 2018
    Assignee: Washington University
    Inventors: Regis J. O'Keefe, Jie Shen, Audrey McAlinden
  • DNA METHYLTRANSFERASES FOR THE TREATMENT AND PREVENTION OF ARTHRITIS
    Publication number: 20170071889
    Abstract: The present disclosure is directed to compositions and methods for treating osteoarthritis comprising increasing the expression of Dnmt3b and/or inhibiting aminobutyrate aminotransferase.
    Type: Application
    Filed: September 14, 2016
    Publication date: March 16, 2017
    Inventors: Regis J. O'Keefe, Jie Shen, Audrey McAlinden
  • PARATHYROID HORMONE TREATMENT FOR ENHANCED ALLOGRAFT AND TISSUE-ENGINEERED RECONSTRUCTION OF BONE DEFECTS
    Publication number: 20090227503
    Abstract: Methods of improving an outcome of a bone allograft procedure in a subject suffering from a massive bone defect are described, including providing a bone allograft to the subject and intermittently providing said subject with parathyroid hormone (PTH); where the PTH is provided in an amount effective to enhance in or adjacent to a bone allograft, relative to a patient not provided the PTH, at least one of callus bone volume, callus mineral content, callus bridging, graft stiffness, graft incorporation, and graft resistance to an applied torque.
    Type: Application
    Filed: February 9, 2009
    Publication date: September 10, 2009
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Hani A. Awad, Edward M. Schwarz, Susan Bukata, J. Edward Puzas, Regis J. O'Keefe, Randy Rosier
  • Light activated gene transduction using long wavelength ultraviolet light for cell targeted gene delivery
    Patent number: 7524327
    Abstract: In accordance with the present invention, methods are provided for treating a patient through the use of ultraviolet light activated gene therapy. Embodiments of the present invention include methods for the utilization of light activated gene therapy to repair and/or rebuild damaged cartilage by introducing a desired gene into a patient's tissue.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: April 28, 2009
    Assignee: University of Rochester
    Inventors: Edward M. Schwarz, Regis J. O'Keefe, Thomas Foster, Jarod C. Finlay
  • LIGHT ACTIVATED GENE TRANSDUCTION USING LONG WAVELENGTH ULTRAVIOLET LIGHT FOR CELL TARGETED GENE DELIVERY
    Publication number: 20090093867
    Abstract: In accordance with the present invention, methods are provided for treating a patient through the use of ultraviolet light activated gene therapy. Embodiments of the present invention include methods for the utilization of light activated gene therapy to repair and/or rebuild damaged cartilage by introducing a desired gene into a patient's tissue.
    Type: Application
    Filed: September 2, 2008
    Publication date: April 9, 2009
    Inventors: Edward M. Schwarz, Regis J. O'Keefe, Thomas Foster, Jarod C. Finlay
  • Light activated gene transduction using long wavelength ultraviolet light for cell targeted gene delivery
    Publication number: 20030236394
    Abstract: In accordance with the present invention, methods are provided for treating a patient through the use of ultraviolet light activated gene therapy. Embodiments of the present invention include methods for the utilization of light activated gene therapy to repair and/or rebuild damaged cartilage by introducing a desired gene into a patient's tissue.
    Type: Application
    Filed: January 31, 2003
    Publication date: December 25, 2003
    Inventors: Edward M. Schwarz, Regis J. O'Keefe, Thomas Foster, Jarod C. Finlay