Abstract: A vaccine preparation comprising an antigen for use in the prophylactic or therapeutic treatment of a subject by intradermal administration through laser-generated micropores, wherein the antigen is linked to a binder of a dermal migratory antigen-presenting cell (APC); and a pharmaceutical preparation comprising an active substance for use in the prophylactic or therapeutic treatment of a subject by intradermal administration through laser-generated micropores, for regional delivery to a target location. The invention further relates to the laser-assisted intradermal administration of antigens accompanied by repeated chemotherapy.

Abstract: A vaccine preparation comprising an antigen for use in the prophylactic or therapeutic treatment of a subject by intradermal administration through laser-generated micropores, wherein the antigen is linked to a binder of a dermal migratory antigen-presenting cell (APC); and a pharmaceutical preparation comprising an active substance for use in the prophylactic or therapeutic treatment of a subject by intradermal administration through laser-generated micropores, for regional delivery to a target location. The invention further relates to the laser-assisted intradermal administration of antigens accompanied by repeated chemotherapy.

Abstract: The laser micro-porator (10) for porating a biological membrane (1), comprises: a) a laser source (7) that emits a pulsed beam (4), the laser source (7) comprising a laser diode (7c); b) optics (8a,8b,8x) that modify the pulsed beam to direct a laser beam (4) of less that 1 mm width on the biological membrane (1); c) a deflector (8f) oriented to direct the laser beam (4) in various directions; d) a laser beam shaping device that reshapes the energy intensity distribution of the laser beam (4); and e) a poration controller (11) that controls the laser source (7) to create a poration consisting of a plurality of individual pores (2) in the biological membrane (1).

Abstract: The transdermal delivery system for treating infertility in a patient comprises an apparatus (10) for facilitating transdermal delivery of a drug (5a) through an area of the apparatus (10) comprises an ablator that is configured to generate a microporation in the area of the skin of the patient, and comprises a drug (5a), wherein the drug effects at least one of the biological regulation of at least one oocyte containing follicle, stimulation of follicle growth, induction of ovulation, promotion of gestational status, maintenance of conceptus, maintenance of pregnancy.

Abstract: A micro-porator (10) for porating a biological membrane (1), comprising: a) a controller (11) b) an initial microporation dataset (D); c) and an ablator (10a) for creating a microporation on the biological membrane (1), the controller (11) controlling the ablator (10a) based on the initial microporation dataset (D), to create the microporation as defined by the initial microporation dataset (D).

Abstract: A system for transmembrane administration of a permeant, the system comprising: a) at least one permeant (5a), b) data of at least one initial microporation dataset (D) for the at least one permeant (5a), c) and a micro-porator (10) configured to porate a biological membrane (1) as defined by the initial microporation dataset (D).

Abstract: There is disclosed a method for creating an initial permeation surface (A) in a biological membrane (1) comprising: a) creating a plurality of individual micropores (2i) in the biological membrane (1), each individual micropore (2i) having an individual permeation surface (Ai); and b) creating such a number of individual micropores (2i) and of such shapes, that the initial permeation surface (A), which is the sum of the individual permeation surfaces (Ai) of all individual micropores (2i), having a desired value. A Microporator performing the method is also disclosed.

Abstract: The transdermal delivery system for treating infertility in a patient comprises an apparatus (10) for facilitating transdermal delivery of a drug (5a) through an area of the apparatus (10) comprises an ablator that is configured to generate a microporation in the area of the skin of the patient, and comprises a drug (5a), wherein the drug effects at least one of the biological regulation of at least one oocyte containing follicle, stimulation of follicle growth, induction of ovulation, promotion of gestational status, maintenance of conceptus, maintenance of pregnancy.

Abstract: The laser micro-porator (10) for porating a biological membrane (1), comprises: a) a laser source (7) that emits a pulsed beam (4), the laser source (7) comprising a laser diode (7c); b) optics (8a,8b,8x) that modify the pulsed beam to direct a laser beam (4) of less that 1 mm width on the biological membrane (1); c) a deflector (8f) oriented to direct the laser beam (4) in various directions; d) a laser beam shaping device that reshapes the energy intensity distribution of the laser beam (4); and e) a poration controller (11) that controls the laser source (7) to create a poration consisting of a plurality of individual pores (2) in the biological membrane (1).

Abstract: An arrangement on a press having an eccentric shaft for adjusting the strokes of a working slide and of a counter-oscillating weight by adjustable eccentric/eccentric bush pairings. The eccentric bushes of these pairings can be detached and fixed on the eccentrics in the rotating direction since the connection is in each case an interference fit with a cylindrical locating surface that can be released by the feeding of pressure oil. This permits a narrow construction of the press with a relatively short eccentric shaft. The eccentrics are arranged directly next to one another on an eccentric shaft, and the eccentric bushes are rotationally connected with one another via radial disks with radial slots and pins engaging in them. The adjusting of the strokes takes place by rotating the eccentric shaft when the interference fits are released and the eccentric bushes are locked.

Abstract: A press arrangement which includes a press table, a punch and an adjusting arrangement for selectively adjusting the distance between the press table and punch. A pressure space is provided in the punch which selectively communicates with a pressure medium supply so as to load and relieve the pressure space. A piston is floatingly disposed in the pressure space and cooperates with an element of the adjusting arrangement so as to create a constantly-acting or permanently-acting tension on the adjusting arrangement when the pressure space is filled with a pressure medium.

Abstract: An arrangement for aligning and stacking laminations for electrical equipment and for transporting formed stacks of laminations with the laminations being fed individually in the same position to a stack former which maintains the relative positions of the laminations. The laminations include a circular inner or outer circumference and a plurality of stampings distributed about the surface of the laminations at equal centering angles. The stack former is provided with an appropriate circular circumference and a guide which can be introduced into at least one stamping. The stack former is rotatably mounted relative to its longitudinal axis and is provided with a rotary drive which operates in a stepwise manner with the rotary steps of the drive being equal to the central angle of the stampings of the stamping pattern or a whole number multiple thereof.