Patents by Inventor Reinhold Deppisch
Reinhold Deppisch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10251979Abstract: The present invention concerns an implantable access device and a method for preparing the device. According to the invention the device comprises a shape memory base structure with a biological substructure suitable for cell adhesion, cell engraftment and proliferation for use in transferring and transporting fluid mixtures (blood, suspensions, drug formulations, emulsions, cell suspensions) in/into/out of a human or animal body.Type: GrantFiled: June 12, 2006Date of Patent: April 9, 2019Assignee: GAMBRO LUNDIA ABInventors: Andrea Schnell, Bernd Wittner, Claudia Hildwein, Ruth Dietrich, Reinhold Deppisch, Doris Deppisch, Werner Beck
-
Patent number: 9902939Abstract: A device for culturing, storing and expanding adherent renal cells. The device permits the adhesion and proliferation of the cells and the surface characteristics of the membrane material used in said device further permit the cellular matrix components (EMC). A method for expanding adherent renal cells and methods of using particular membranes for culturing, storing and expanding adherent renal cells. The membranes comprise a copolymer of acrylonitrile and sodium methallyl sulfonate as well as polyethylenimine.Type: GrantFiled: September 23, 2009Date of Patent: February 27, 2018Assignee: Gambro Lundia ABInventors: David Luttropp, Markus Neubauer, Helmut Geiger, Juergen Bereiter-Hahn, Patrick Baer, Reinhold Deppisch, Doris Deppisch
-
Patent number: 8821906Abstract: The present disclosure relates to a biocompatible polymer composition for an article comprising a surface intended to contact blood, tissue, skin, epithelial layers, wounds, cells in culture fluids, body fluids, dialysis fluids, therapeutic fluids, or mixtures thereof for removal or infusion. The invention also relates to a method for the preparation of an article comprising the biocompatible polymer composition and a use thereof.Type: GrantFiled: May 24, 2004Date of Patent: September 2, 2014Assignee: Gambro Lundia ABInventors: Reinhold Deppisch, Ruth Dietrich, Werner Beck, Andrea Schnell, Bernd Wittner
-
Patent number: 8771215Abstract: A machine (1) for extracorporeal blood treatment comprises a device (2) for ultrafiltration of a liquid through a semi-permeable membrane (3) of a blood treatment device (4), a first sensor (11) for ultrafiltration rate through the membrane, a second group of sensors (13) for measuring a trans-membrane pressure, an infusion line (16) with an infusion pump (17) and a programmed controller (14) for calculating a maximum infusion rate as a function of the transmembrane pressure. The machine is suitable for kidney failure treatments, such as hemofiltration and hemodiafiltration. In a relatively short time the machine enables a large quantity of corporeal blood to be removed from the patient.Type: GrantFiled: December 20, 2011Date of Patent: July 8, 2014Assignee: Cambro Lundia ABInventors: Claudio Tonelli, Bernd Wittner, Werner Beck, Helmut Hildwein, Reinhold Deppisch, Jonas Svensson, Bjorn Ericson
-
Patent number: 8454564Abstract: A device for applying a lock solution in a catheter or other access system comprises a syringe (302) having an expulsion arrangement (305, 311) for expelling the lock solution from the device, said expulsion arrangement including a plunger (305) arranged in a housing (304), further comprising a sterile connector (303) for connecting the syringe (302) to the catheter. The connector (303) is arranged to engage a tip (307) of the expulsion arrangement (305, 311) tightly when the syringe (302) is inserted in the connector (303). The connector (303) is arranged to prevent the tip (307) of the expulsion arrangement (305, 311) from entering the catheter. The tip (307) is frangible. A method of applying a lock solution in a catheter or other access system is also disclosed.Type: GrantFiled: June 15, 2005Date of Patent: June 4, 2013Assignee: Gambro Lundia ABInventors: Reinhold Deppisch, Werner Beck, Ruth Dietrich, Björn Frederik Seidler, Andrea Schnell, Claudia Hildwein
-
Publication number: 20120145626Abstract: A device for culturing, storing and expanding adherent renal cells. The device permits the adhesion and proliferation of the cells and the surface characteristics of the membrane material used in said device further permit the cellular matrix components (EMC). A method for expanding adherent renal cells and methods of using particular membranes for culturing, storing and expanding adherent renal cells. The membranes comprise a copolymer of acrylonitrile and sodium methallyl sulfonate as well as polyethylenimine.Type: ApplicationFiled: September 23, 2009Publication date: June 14, 2012Applicant: GAMBRO LUNDIA ABInventors: David Luttropp, Markus Neubauer, Helmut Geiger, Juergen Bereiter-Hahn, Patrick Baer, Reinhold Deppisch, Doris Deppisch
-
Publication number: 20120095381Abstract: A machine (1) for extracorporeal blood treatment comprises a device (2) for ultrafiltration of a liquid through a semi-permeable membrane (3) of a blood treatment device (4), a first sensor (11) for ultrafiltration rate through the membrane, a second group of sensors (13) for measuring a trans-membrane pressure, an infusion line (16) with an infusion pump (17) and a programmed controller (14) for calculating a maximum infusion rate as a function of the transmembrane pressure. The machine is suitable for kidney failure treatments, such as hemofiltration and hemodiafiltration. In a relatively short time the machine enables a large quantity of corporeal blood to be removed from the patient.Type: ApplicationFiled: December 20, 2011Publication date: April 19, 2012Applicant: GAMBRO LUNDIA ABInventors: Claudio TONELLI, Bernd WITTNER, Werner BECK, Helmut HILDWEIN, Reinhold DEPPISCH, Jonas SVENSSON, Bjorn ERICSON
-
Publication number: 20120067815Abstract: A bioartificial kidney equivalent and a process for producing the bioartificial kidney equivalent. The hybrid bioartificial kidney comprises human proximal and distal renal tubule cells grown on particular synthetic membranes.Type: ApplicationFiled: September 23, 2009Publication date: March 22, 2012Applicant: GAMBRO LUNDIA ABInventors: David Luttropp, Bernd Krause, Markus Neubauer, Reinhold Deppisch, Doris Deppisch, Andrea Schnell, Helmut Geiger, Juergen Bereiter-Hahn, Patrick Baer
-
Patent number: 8105260Abstract: A machine (1) for extracorporeal blood treatment comprises a device (2) for ultrafiltration of a liquid through a semi-permeable membrane (3) of a blood treatment device (4), a first sensor (11) for ultrafiltration rate through the membrane, a second group of sensors (13) for measuring a trans-membrane pressure, and a programmed controller (14) for calculating a maximum ultrafiltration rate as a function of the transmembrane pressure. The machine is suitable for kidney failure treatments, such as hemofiltration and hemodiafiltration. In a relatively short time the machine enables a large quantity of corporeal blood to be removed from the patient.Type: GrantFiled: May 27, 2005Date of Patent: January 31, 2012Assignee: Gambro Lundia ABInventors: Claudio Tonelli, Bernd Wittner, Werner Beck, Helmut Hildwein, Reinhold Deppisch, Jonas Svensson, Bjorn Ericson
-
Publication number: 20110263020Abstract: A membrane which can be used for cultivating cells, in particular adherent cells. The membrane permits the adhesion and proliferation of the cells based on its specific composition comprising polyurethane. The resulting surface characteristics further permit the membrane to be used without any pre-treatment with surface modifying substances. A method for preparing a membrane which can be used for cultivating cells, in particular adherent cells. Methods of using the membrane for cultivating cells, in particular adherent cells.Type: ApplicationFiled: September 23, 2009Publication date: October 27, 2011Applicant: GAMBRO LUNDIA ABInventors: Carina Zweigart, Bernd Krause, Markus Neubauer, Reinhold Deppisch, Doris Deppisch
-
Publication number: 20110160664Abstract: A device for applying a lock solution in a catheter or other access system comprises a syringe (302) having an expulsion arrangement (305, 311) for expelling the lock solution from the device, said expulsion arrangement including a plunger (305) arranged in a housing (304), further comprising a sterile connector (303) for connecting the syringe (302) to the catheter. The connector (303) is arranged to engage a tip (307) of the expulsion arrangement (305, 311) tightly when the syringe (302) is inserted in the connector (303). The connector (303) is arranged to prevent the tip (307) of the expulsion arrangement (305, 311) from entering the catheter. The tip (307) is frangible. A method of applying a lock solution in a catheter or other access system is also disclosed.Type: ApplicationFiled: June 15, 2005Publication date: June 30, 2011Inventors: Reinhold Deppisch, Werner Beck, Ruth Dietrich, Björn Frederik Seidler, Andrea Schnell, Claudia Hildwein
-
Publication number: 20110015720Abstract: The present invention concerns an implantable access device and a method for preparing the device. According to the invention the device comprises a shape memory base structure with a biological substructure suitable for cell adhesion, cell engraftment and proliferation for use in transferring and transporting fluid mixtures (blood, suspensions, drug formulations, emulsions, cell suspensions) in/into/out of a human or animal body.Type: ApplicationFiled: June 12, 2006Publication date: January 20, 2011Inventors: Andrea Schnell, Bernd Wittner, Claudia Hildwein, Ruth Dietrich, Reinhold Deppisch, Doris Deppisch, Werner Beck
-
Publication number: 20100320146Abstract: The invention relates to hydrophilic membranes which are supplemented or treated with a non-ionic surfactant and processes for preparing such membranes. The membranes are particularly suitable for plasma separation or for haemodialysis and haemodiafiltration, but can also advantageously be used in other applications. Accordingly, the invention is further directed to the use of such membranes for plasma separation, plasma filtration, micro filtration, plasma therapy, haemodialysis and haemodiafiltration or cell filtration applications, respectively. The treated hydrophilic membranes show excellent biocompatibility, such as reduced platelet drop and decreased TAT levels.Type: ApplicationFiled: September 26, 2008Publication date: December 23, 2010Inventors: Bernd Krause, Markus Hornung, Reinhold Deppisch, Doris Deppisch, Silvia Koch
-
Publication number: 20100204328Abstract: The present invention concerns a solution and methods to reduce, treat and/or prevent oxidative stress and cell activation. According to the invention the solution gives rise to the following concentrations of constituents within a blood flow of 0.1-18 mM N-acetyl-cysteine, optionally of 0.01-0.21 mM vitamin C, optionally of 2-26 mM gluconic acid and optionally of 0.01-5 mM glutathione. According to the invention the methods comprises adding a solution according to the invention in an extracorporeal setting through the membrane by adding the solution to the dialysis fluid, or by infusion of a solution according to the invention, either by bolus injection, continuous injection or a combination thereof.Type: ApplicationFiled: June 21, 2007Publication date: August 12, 2010Inventors: Reinhold Deppisch, Doris Deppisch, Werner Beck, Andrea Schnell, Hans-Rainer Drieschmanns
-
Patent number: 7591948Abstract: A process for production of a microporous affinity membrane having regioselective affinity for compounds in blood or other biologically active fluids to be removed during purification of blood or said fluids is disclosed, as well as a microporous affinity membrane produced by said process, an adsorption device containing such a microporous affinity membrane, and use of such a microporous affinity membrane.Type: GrantFiled: April 23, 2003Date of Patent: September 22, 2009Assignees: Gambro Lundia AB, Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung E.V.Inventors: Michael Müller, Christian Oehr, Heinrich Malthaner, Hermann Goehl, Reinhold Deppisch, Markus Storr
-
Publication number: 20090163599Abstract: The present invention concerns an apheresis material or adsorbant and a method for removing, depleting or inactivating MIF (macrophage migration inhibitory factor) from blood, blood plasma, blood serum or other body fluids. The present invention is also concerned with the use of said apheresis material or adsorbant. In order to prepare a novel means and novel method, which can reduce the activity or amount of the mediator for sepsis and septic shock, MIF, in a patient's body fluid in a manner which is more pleasant and tolerable for the patient than prior art means and methods, the invention proposes that the apheresis material or adsorbant comprises a solid carrier material on the surface of which MIF-binding molecules or functional groups are immobilized. The method proposes that the apheresis material or adsorbant be brought into contact extracorporeally with the blood, blood plasma, blood serum or other body fluids.Type: ApplicationFiled: June 3, 2005Publication date: June 25, 2009Inventors: Markus Storr, Reinhold Deppisch, Werner Beck, Jürgen Bernhagen, Ina Merz, Georg Geiger
-
Publication number: 20090047654Abstract: A polymer affinity matrix for the binding of one or more substances in a fluid or removing said substance(s) from the fluid and/or decreasing the amount or concentration thereof in said fluid with a view to preventing, eliminating or reducing undesired activation of components in said fluid is described, as well as a method for removing said substance(s) from the fluid and/or decreasing the amount or concentration thereof in said fluid, a method for the production of said matrix, use of said matrix and a kit comprising said matrix. The polymer affinity matrix comprises a solid support, a spacer and a ligand, containing arginine as a binding unit.Type: ApplicationFiled: July 21, 2008Publication date: February 19, 2009Inventors: Wolfgang Rapp, Reinhold Deppisch, Hermann Gohl, Bernd Wittner, Werner Beck
-
Publication number: 20080268538Abstract: The present invention provides a device for cell culture. The device comprises a culture zone, a selective sorption zone and culture media transfer means. Culture media is transferred or recirculated from the culture zone through the selective sorption zone which comprises at least one agent reactive with cytotoxic degradation products present in the culture media and back to the culture zone via the culture media transfer means.Type: ApplicationFiled: September 12, 2005Publication date: October 30, 2008Inventors: Robert Nordon, Michael R. Doran, Reinhold Deppisch
-
Publication number: 20080215247Abstract: A machine (1) for extracorporeal blood treatment comprises a device (2) for ultrafiltration of a liquid through a semi-permeable membrane (3) of a blood treatment device (4), a first sensor (11) for ultrafiltration rate through the membrane, a second group of sensors (13) for measuring a trans-membrane pressure, and a programmed controller (14) for calculating a maximum ultrafiltration rate as a function of the transmembrane pressure. The machine is suitable for kidney failure treatments, such as hemofiltration and hemodiafiltration. In a relatively short time the machine enables a large quantity of corporeal blood to be removed from the patient.Type: ApplicationFiled: May 27, 2005Publication date: September 4, 2008Inventors: Claudio Tonelli, Bernd Wittner, Werner Beck, Helmut Hildwein, Reinhold Deppisch, Jonas Svensson, Bjorn Ericson
-
Publication number: 20060275368Abstract: The present disclosure relates to a biocompatible polymer composition for an article comprising a surface intended to contact blood, tissue, skin, epithelial layers, wounds, cells in culture fluids, body fluids, dialysis fluids, therapeutic fluids, or mixtures thereof for removal or infusion. The invention also relates to a method for the preparation of an article comprising the biocompatible polymer composition and a use thereof.Type: ApplicationFiled: May 24, 2004Publication date: December 7, 2006Inventors: Reinhold Deppisch, Ruth Dietrich, Werner Beck, Andrea Schnell, Bernd Wittner