Publication number: 20060142317
Abstract: The invention relates to 3,4-dihydro-thieno[2,3-d]pyrimidin-4-one derivatives which are substituted in position 3 by 5-membered heteroaryl which may be fused to an aryl or heteroaryl radical, where the heteroaryl and, if appropriate, the fused aryl or heteroaryl radical may have 1, 2 or 3 substituents selected independently of one another from C1-5-alkyl, C1-5-alkoxy, C1-5-alkylthio, halogen, CN, halo-C1-5-alkyl, halo-C1-5-alkoxy, hydroxy, —NH2, —N(R6)2, —NH(R6), aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl, where the substituents aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl may have 1, 2 or 3 substituents selected independently of one another from C1-5-alkyl, C1-5-alkoxy, C1-5-alkylthio, halogen, CN, halo-C1-5-alkyl, halo-C1-5-alkoxy, hydroxy, —NH2, —N(R6)2 and —NH(R6). The preparation and use of these derivatives, especially for therapeutic purposes, e.g. for the treatment of depressions, are likewise described.
Type:
Application
Filed:
December 17, 2003
Publication date:
June 29, 2006
Inventors:
Margaretha Bakker, Wilfried Hornberger, Andreas Kling, Udo Lange, Helmut Mack, Achim Moeller, Reinhold Mueller, Kurt Schelhaas, Martin Schmidt, Gerd Steiner, Karsten Wicke
Publication number: 20030134843
Abstract: The invention relates to compounds of formula (I), wherein; either A1 or A2 represents CONH2, and the other radical A2 or A1 represents hydrogen, chlorine, fluorine, bromine, iodine C1-C6 alkyl, OH, nitro, CF3, CN, NR11R12, NH—CO—R13, O—C1-C4 alkyl; X1 can represent N and C—R2; X2, independent of X1, can represent N and C—R2; R2 can represent hydrogen, C1-C6 alkyl, C1-C4 alkyl-phenyl, phenyl; B can represent an unsaturated, saturated or partially unsaturated monocyclic, bicyclic or tricyclic ring having a maximum of 15 carbon atoms, an unsaturated, saturated or partially unsaturated monocyclic, bicyclic or tricyclic ring having a maximum of 14 carbon atoms and 0 to 5 nitrogen atoms, 0 to 2 oxygen atoms or 0 to 2 sulfur atoms, which can each still be substituted with an R4 and a maximum of 3 of the same or different radicals R5, and; R1, R4, R5, R11-R13 have the meanings as cited in claim No. 1.
Type:
Application
Filed:
November 18, 2002
Publication date:
July 17, 2003
Inventors:
Wilfried Lubisch, Michael Kock, Thomas Hoeger, Roland Grandel, Reinhold Mueller, Sabine Schult