Patents by Inventor Rejean Ruel

Rejean Ruel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
    Patent number: 6369082
    Abstract: This invention encompasses the novel compounds of formula A, which are useful in the treatment of prostaglandin mediated diseases, or a pharmaceutically acceptable salt, hydrate or ester thereof. The invention also encompasses pharmaceutical compositions and methods for treatment of prostaglandin mediated diseases.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: April 9, 2002
    Assignee: Merck Frosst Canada & Co.
    Inventors: Patrick Lacombe, Marc Labelle, Rejean Ruel
  • Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
    Patent number: 6369084
    Abstract: This invention encompasses the novel compounds of formula A, which are useful in the treatment of prostaglandin mediated diseases, or a pharmaceutically acceptable salt, hydrate or ester thereof. The invention also encompasses certain pharmaceutical compositions and methods for treatment of prostaglandin mediated diseases comprising the use of compounds of formula A.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: April 9, 2002
    Assignee: Merck Frosst Canada & Co.
    Inventors: Patrick Lacombe, Marc Labelle, Rejean Ruel
  • Biphenylene lactams as prostaglandin receptor ligands
    Patent number: 6277839
    Abstract: The present invention relates to biphenylene lactams of Formula II which are ligands at the prostaglandin receptors, as well as a method for treating prostaglandin mediated diseases comprising administration to a patient in need of such a treatment of a non-toxic therapeutically effective amount of compound of Formula II, and the like.
    Type: Grant
    Filed: October 1, 1999
    Date of Patent: August 21, 2001
    Assignee: Merck Frosst Canada & Co.
    Inventors: Joseph G. Atkinson, Marc Labelle, Patrick Lacombe, Rejean Ruel
  • Prostaglandin conjugates for treating or preventing bone disease
    Patent number: 6121253
    Abstract: This invention relates to prostaglandin-bisphosphonate conjugates. These conjugates are effective for treating or preventing bone diseases such as osteoporosis. These conjugates simultaneously deliver a prostaglandin agent for increasing bone formation and a bisphosphonate agent for inhibiting bone resorption.
    Type: Grant
    Filed: November 15, 1999
    Date of Patent: September 19, 2000
    Assignee: Merck Frosst Canada & Co.
    Inventors: Yongxin Han, Robert N. Young, Laurent Gil, Rejean Ruel
  • Method for identifying inhibitors for apopain based upon the crystal structure of the apopain: Ac-DEVD-CHO complex
    Patent number: 5834228
    Abstract: The apopain:Ac-DEVD-CHO complex has been crystallized and its structure determined by x-ray crystallography. Based upon this crystal structure of the complex, a method for identifying inhibitors of apopain is presented which comprises designing putative inhibitors having specific contacts with apopain, making the putative inhibitors, and testing the putative inhibitors for their ability to inhibit apopain.
    Type: Grant
    Filed: February 13, 1997
    Date of Patent: November 10, 1998
    Assignees: Merck & Co., Inc., Merck Frosst Canada, Inc.
    Inventors: Joseph W. Becker, Donald W. Nicholson, Jennifer Rotonda, Nancy A. Thornberry, Kimberly M. Fazil, Michel Gallant, Yves Gareau, Marc Labelle, Erin P. Peterson, Dita M. Rasper, Rejean Ruel, John P. Vaillancourt