Patents by Inventor Rena Lapidus

Rena Lapidus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LINKED DIARYL COMPOUNDS WITH ANTICANCER PROPERTIES AND METHODS OF USING THE SAME
    Publication number: 20190209548
    Abstract: Provided are compositions comprising linked diaryl compounds that possess anticancer properties. Methods of use are also disclosed herein. The method comprises administering an effective amount of a compound described herein to an individual in need thereof.
    Type: Application
    Filed: November 19, 2018
    Publication date: July 11, 2019
    Inventors: Herman O. Sintim, Jie Zhou, Changhao Wang, Rena Lapidus
  • Linked diaryl compounds with anticancer properties and methods of using the same
    Patent number: 10130625
    Abstract: Provided are compositions comprising linked diaryl compounds that possess anticancer properties. Methods of use are also disclosed herein. The method comprises administering an effective amount of a compound described herein to an individual in need thereof.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: November 20, 2018
    Assignees: University of Maryland, College Park, University of Maryland, Baltimore
    Inventors: Herman O. Sintim, Jie Zhou, Changhao Wang, Rena Lapidus
  • LINKED DIARYL COMPOUNDS WITH ANTICANCER PROPERTIES AND METHODS OF USING THE SAME
    Publication number: 20170174620
    Abstract: Provided are compositions comprising linked diaryl compounds that possess anticancer properties. Methods of use are also disclosed herein. The method comprises administering an effective amount of a compound described herein to an individual in need thereof.
    Type: Application
    Filed: July 22, 2015
    Publication date: June 22, 2017
    Inventors: Herman O. SINTIM, Shizuka NAKAYAMA, Dimpy KALIA, Jie ZHOU, Min GUO, Jinbing LIU, Changhao WANG, Rena LAPIDUS
  • Certain compounds, compositions and methods
    Patent number: 9567363
    Abstract: The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: February 14, 2017
    Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Gregory S. Hamilton, Takashi Tsukamoto, Dana V. Ferraris, Bridget Duvall, Rena Lapidus
  • Compositions and methods for the treatment of cancers
    Patent number: 9381215
    Abstract: The present invention provides a formulation comprising dichloroacetate and arsenic trioxide. The present invention also provides a method of treating cancer by administering a therapeutically effective amount of dichloroacetate and arsenic trioxide.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: July 5, 2016
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Ashkan Emadi, Rena Lapidus, Mariola Sadowska, Brandon Carter-Cooper, Edward Sausville
  • Compositions and Methods for the Treatment of Cancers
    Publication number: 20150231176
    Abstract: The present invention provides a formulation comprising dichloroacetate and arsenic trioxide. The present invention also provides a method of treating cancer by administering a therapeutically effective amount of dichloroacetate and arsenic trioxide.
    Type: Application
    Filed: February 17, 2015
    Publication date: August 20, 2015
    Applicant: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Ashkan Emadi, Rena Lapidus, Mariola Sadowska, Brandon Carter-Cooper, Edward Sausville
  • CERTAIN COMPOUNDS, COMPOSITIONS AND METHODS
    Publication number: 20150210730
    Abstract: The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.
    Type: Application
    Filed: December 29, 2014
    Publication date: July 30, 2015
    Inventors: Gregory S. Hamilton, Takashi Tsukamoto, Dana V. Ferraris, Bridget Duvall, Rena Lapidus
  • Certain compounds, compositions and methods
    Patent number: 8951987
    Abstract: The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: February 10, 2015
    Assignee: Otsuka Pharmaceuticals Co., Ltd.
    Inventors: Gregory S. Hamilton, Takashi Tsukamoto, Dana V. Ferraris, Bridget Duvall, Rena Lapidus
  • Certain Compounds, Compositions and Methods
    Publication number: 20140186335
    Abstract: The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.
    Type: Application
    Filed: November 25, 2013
    Publication date: July 3, 2014
    Applicant: Eisai Inc.
    Inventors: Gregory S. Hamilton, Takashi Tsukamoto, Dana V. Ferraris, Bridget Duvall, Rena Lapidus
  • Certain compounds, compositions and methods
    Patent number: 8618075
    Abstract: The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.
    Type: Grant
    Filed: July 24, 2012
    Date of Patent: December 31, 2013
    Assignee: Eisai Inc.
    Inventors: Gregory S. Hamilton, Takashi Tsukamoto, Dana V. Ferraris, Bridget Duvall, Rena Lapidus
  • Certain Compounds, Compositions and Methods
    Publication number: 20120289475
    Abstract: The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.
    Type: Application
    Filed: July 24, 2012
    Publication date: November 15, 2012
    Inventors: Gregory S. Hamilton, Takashi Tsukamoto, Dana V. Ferraris, Bridget Duvall, Rena Lapidus
  • Certain compounds, compositions and methods
    Patent number: 8268800
    Abstract: The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.
    Type: Grant
    Filed: October 16, 2008
    Date of Patent: September 18, 2012
    Assignee: Eisai Inc.
    Inventors: Gregory S. Hamilton, Takashi Tsukamoto, Dana V. Ferraris, Bridget Duvall, Rena Lapidus
  • Certain Compounds, Compositions and Methods
    Publication number: 20090137521
    Abstract: The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.
    Type: Application
    Filed: October 16, 2008
    Publication date: May 28, 2009
    Inventors: Gregory S. Hamilton, Takashi Tsukamoto, Dana V. Ferraris, Bridget Duvall, Rena Lapidus
  • Compositions for treatment of prostate cancers and methods of making and using the same
    Publication number: 20030133903
    Abstract: The present invention relates to compositions of a biocompatible polymer and an antineoplastic agent, and methods of using and making the same, for the treatment of prostate cancers. In certain embodiments, the polymer contains phosphorous linkages.
    Type: Application
    Filed: July 19, 2002
    Publication date: July 17, 2003
    Inventors: Wenbin Dang, Rena Lapidus, William Vincek
  • Pharmaceutical compositions and methods of inhibiting angiogenesis using NAALADase inhibitors
    Publication number: 20030064912
    Abstract: The present disclosure relates to a method of inhibiting angiogenesis comprising administering a N-Acetylated &agr;-Linked Acidic Dipeptidase (NAALADase) inhibitor to a patient in need thereof, and a pharmaceutical composition comprising an anti-angiogenic effective amount of a NAALADase inhibitor and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: April 11, 2002
    Publication date: April 3, 2003
    Inventors: Barbara S. Slusher, Rena Lapidus
  • Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors
    Patent number: 6395718
    Abstract: The present disclosure relates to a method of inhibiting angiogenesis comprising administering a N-Acetylated &agr;-Linked Acidic Dipeptidase (NAALADase) inhibitor to a patient in need thereof, and a pharmaceutical composition comprising an anti-angiogenic effective amount of a NAALADase inhibitor and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: July 6, 1998
    Date of Patent: May 28, 2002
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Barbara S. Slusher, Rena Lapidus
  • Thio-substituted pentanedioic acid derivatives
    Patent number: 6265609
    Abstract: The present invention relate to thio-substituted pentanedioic acid derivatives that inhibit N-Acetylated &agr;-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising the same, and methods of using the same to inhibit NAALADase enzyme activity, to effect neuronal activities, to inhibit angiogenesis, and to treat glutamate abnormalities, compulsive disorders and prostate diseases.
    Type: Grant
    Filed: January 12, 1999
    Date of Patent: July 24, 2001
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Keith M. Maclin, Eric Wang, Barbara S. Slusher, Rena Lapidus