Abstract: The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently labeled anti-lymphocyte and anti-platelet antibodies demonstrated an increase in rosette formation in the presence of PIF. It is further based on the observation that flow cytometry demonstrated that monoclonal antibody binding to CD2 decreased in the presence of PIF. The present invention further relates to PIF peptides which, when added to Jurkat cell cultures, have been observed to either (i) decrease binding of anti-CD2 antibody to Jurkat cells; (ii) increase expression of CD2 in Jurkat cells; or (iii) decrease Jurkat cell viability.

Abstract: The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently labeled anti-lymphocyte and anti-platelet antibodies demonstrated an increase in rosette formation in the presence of PIF. It is further based on the observation that flow cytometry demonstrated that monoclonal antibody binding to CD2 decreased in the presence of PIF. The present invention further relates to PIF peptides which, when added to Jurkat cell cultures, have been observed to either (i) decrease binding of anti-CD2 antibody to Jurkat cells; (ii) increase expression of CD2 in Jurkat cells; or (iii) decrease Jurkat cell viability.

Abstract: The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently labeled anti-lymphocyte and anti-platelet antibodies demonstrated an increase in rosette formation in the presence of PIF. It is further based on the observation that flow cytometry demonstrated that monoclonal antibody binding to CD2 decreased in the presence of PIF. The present invention further relates to PIF peptides which, when added to Jurkat cell cultures, have been observed to either (i) decrease binding of anti-CD2 antibody to Jurkat cells; (ii) increase expression of CD2 in Jurkat cells; or (iii) decrease Jurkat cell viability.

Abstract: The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently labeled anti-lymphocyte and anti-platelet antibodies demonstrated an increase in rosette formation in the presence of PIF. It is further based on the observation that flow cytometry demonstrated that monoclonal antibody binding to CD2 decreased in the presence of PIF. The present invention further relates to PIF peptides which, when added to Jurkat cell cultures, have been observed to either (i) decrease binding of anti-CD2 antibody to Jurkat cells; (ii) increase expression of CD2 in Jurkat cells; or (iii) decrease Jurkat cell viability.

Abstract: Disclosed herein are peptides comprising a leptin sequence and methods for their use in preventing ObR signaling in a leptin-responsive cell. A leptin peptide of the present invention binds to but does not activate ObR signaling in a leptin-responsive cell, thereby inhibiting the up-regulatory effects of leptin on ObR signaling in the leptin-responsive cell. Administration of the peptide effectively prevents embryo implantation in a mammal to which the peptide has been administered. Also disclosed herein is a method for identifying a peptide antagonist of ObR, wherein the peptide comprises a leptin sequence.

Abstract: A method for barrier property enhancement using silicon containing agents and in situ formation of nanoscopic glass layers on polymer surfaces. Nanostructured chemicals such as polyhedral oligomeric silsesquioxane (POSS) are added to polymers, followed by in situ surface oxidation to form a glass layer.

Abstract: A multi-hit transparent armor system is described and claimed herein for improving the resistance of transparent armor to incoming projectiles. Typically, the transparent armor is framed within a window opening of a security structure. An exemplary, contemplated structure is an armored combat vehicle. My system includes a sheet of tempered glass that is also positioned within said window, but is deployed outboard of said transparent armor and is also parallel planar thereto. Positioned below said sheet of tempered glass, and coaxial thereto, is an opaque armor panel that is more efficient and effective against multiple projectiles than either the tempered glass or transparent armor alone. The tempered glass sheet and the opaque armor are typically loaded under compression by a spring assembly. An incoming projectile, launched from a position outboard and also remote from said structure, will first strike the tempered glass before hitting my transparent armor.

Abstract: An improved reactive armor is disclosed. The armor has means which impinge n a penetrating threat to destroy its integrity and prevent incursion to the interior of an armored vehicle.

Abstract: Disclosed herein is a cast or molded structural panel having two plates or sheets integrally joined to an intermediate zone. The intermediate zone is formed either of a cross corrugated panel or a double tray structure between the plates. The cross corrugated panel may be regarded as having a first set of corrugations perpendicularly intersecting a second set of corrugations. The double tray structure may be described as two arrays of hollow pyramids whose bases are joined to one of the sheets. One array of pyramids fits in an interdigitally complementary fashion into the other array of pyramids, and the two trays are integrally joined at the areas of contract between pyramids. Filler material may occupy the cavities defined by the intermediate zone and the plates. In the case of an apertured intermediate zone, the fillter will form a continuous lattice-like structure interwoven with this zone.

Abstract: Aminohydroxy fatty acid amides obtained by condensation from epoxidized fatty acid alkyl esters and polyfunctional aliphatic oligoamines may be employed as crosslinking agents for polyfunctional epoxide compounds used as adhesives and/or coating compositions.