Patents by Inventor Rene S. Schloss
Rene S. Schloss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210139833Abstract: Described herein is a cell culture device and methods of use in three-dimensional cell co-cultures and for use in studying paracrine signaling in vitro.Type: ApplicationFiled: November 6, 2020Publication date: May 13, 2021Inventors: Martin L. Yarmush, Anil Shrirao, Rene S. Schloss, Ileana Marrero-Berrios
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Patent number: 10668102Abstract: This application discloses alginate microencapsulation-mediated differentiation of embryonic stem cells and use of the stem cell differentiation method for the development of effective treatment of various diseases and disorders. The microencapsulation of embryonic stem (ES) cells results in decreased cell aggregation and enhanced neural lineage differentiation through incorporating the soluble inducer retinoic acid (RA) into the permeable microcapsule system. This differentiation process can be augmented by differentiation pathway regulators such as PPAR agonists.Type: GrantFiled: October 20, 2016Date of Patent: June 2, 2020Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Jean-Pierre Dolle, Rene S. Schloss, Martin L. Yarmush
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Patent number: 10495631Abstract: The present invention relates to a system and methods for identifying a compound for de-fatting and functional recovery of macrosteatotic hepatocytes.Type: GrantFiled: July 17, 2017Date of Patent: December 3, 2019Assignee: Rutgers, The State University of New JerseyInventors: Martin L. Yarmush, Nir I. Nativ, Francois Berthiaume, Gabriel A. Yarmush, Tim Maguire, Rene S. Schloss
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Patent number: 10209241Abstract: This invention discloses devices and methods for high throughput skin sensitization detection. The devices comprise a microfabricated chamber comprising a region having one or more input channels and an outlet, and a face suitable for mounting a skin tissue and in fluidic communication with the region. The devices can be used in the methods for determining a prognosis of sensitization in an animal subject and identifying compounds that do not cause sensitization and thus are suitable for preparing cosmetic compositions.Type: GrantFiled: August 10, 2012Date of Patent: February 19, 2019Assignee: Rutgers, The State University of New JerseyInventors: Tim Maguire, Martin L. Yarmush, Rene S. Schloss, Bhaskar Mitra, Rohit Jindal, Mehdi Ghodbane
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Publication number: 20170370909Abstract: The present invention relates to a system and methods for identifying a compound for de-fatting and functional recovery of macrosteatotic hepatocytes.Type: ApplicationFiled: July 17, 2017Publication date: December 28, 2017Applicant: Rutgers, The State University of New JerseyInventors: Martin L. Yarmush, Nir I. Nativ, Francois Berthiaume, Gabriel A. Yarmush, Tim Maguire, Rene S. Schloss
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Patent number: 9709554Abstract: The present invention relates to a system and methods for identifying a compound for de-fatting and functional recovery of macrosteatotic hepatocytes.Type: GrantFiled: January 31, 2014Date of Patent: July 18, 2017Assignee: Rutgers, The State University of New JerseyInventors: Martin L. Yarmush, Nir I. Nativ, Francois Berthiaume, Gabriel A. Yarmush, Tim Maguire, Rene S. Schloss
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Publication number: 20170100435Abstract: This application discloses a micro-encapsulation system for immobilizing mesenchymal stromal cells (MSCs) while sustaining the molecular communication. Thus, the invention provides the use of encapsulated mesenchymal stromal cells in the cellular transplantation therapies. Moreover, the invention provides methods for delivery of encapsulated MSCs into the central nervous system and therapies derived therefrom, such as, the treatment of spinal cord injury (SCI) and other inflammatory conditions.Type: ApplicationFiled: October 20, 2016Publication date: April 13, 2017Applicant: Rutgers, The State University of New JerseyInventors: Martin Grumet, Martin L. Yarmush, Rene S. Schloss, Jeffrey Barminko
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Publication number: 20170100436Abstract: This application discloses alginate microencapsulation-mediated differentiation of embryonic stem cells and use of the stem cell differentiation method for the development of effective treatment of various diseases and disorders. The microencapsulation of embryonic stem (ES) cells results in decreased cell aggregation and enhanced neural lineage differentiation through incorporating the soluble inducer retinoic acid (RA) into the permeable microcapsule system. This differentiation process can be augmented by differentiation pathway regulators such as PPAR agonists.Type: ApplicationFiled: October 20, 2016Publication date: April 13, 2017Applicant: Rutgers, The State University of New JerseyInventors: Jean-Pierre Dolle, Rene S. Schloss, Martin L. Yarmush
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Patent number: 8993328Abstract: The present invention provides systems and methods for improving the efficiency of a transient gene delivery system to differentiating embryonic stem (ES) cells by serum starving the targeted cells for one to three days prior to transfection. Such a serum starvation surprisingly resulted in increased expression of a constitutively-controlled plasmid from 50.4% to 83.2% of the population and increased expression of a promoter/enhancer controlled plasmid from ˜1.4% to ˜3.7% of the population.Type: GrantFiled: September 22, 2009Date of Patent: March 31, 2015Assignee: Rutgers, The State University of New JerseyInventors: Martin L. Yarmush, Eric J. Wallenstein, Rene S. Schloss
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Publication number: 20140336078Abstract: This invention discloses devices and methods for high throughput skin sensitization detection. The devices comprise a microfabricated chamber comprising a region having one or more input channels and an outlet, and a face suitable for mounting a skin tissue and in fluidic communication with the region. The devices can be used in the methods for determining a prognosis of sensitization in an animal subject and identifying compounds that do not cause sensitization and thus are suitable for preparing cosmetic compositions.Type: ApplicationFiled: August 10, 2012Publication date: November 13, 2014Applicant: Rutgers, The State University of New JerseyInventors: Tim Maguire, Martin L. Yarmush, Rene S. Schloss, Bhaskar Mitra, Rohit Jindal, Mehdi Ghodbane
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Publication number: 20140212918Abstract: The present invention relates to a system and methods for identifying a compound for de-fatting and functional recovery of macrosteatotic hepatocytes.Type: ApplicationFiled: January 31, 2014Publication date: July 31, 2014Applicant: Rutgers, The State University of New JerseyInventors: Martin L. Yarmush, Nir I. Nativ, Francois Berthiaume, Gabriel A. Yarmush, Tim Maguire, Rene S. Schloss
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Publication number: 20140213466Abstract: The present invention provides methods for high-throughput assessment of in vivo skin sensitizing activity of chemical compounds through detection of secretion levels of cytokine markers implicated in skin sensitization in combination with a multivariate analysis, using support vector machine (SVM) for feature selection. The invention includes a computational algorithm that will provide unbiased analysis on the skin cell secretome data and predict the level of skin sensitization. The invention allows accurate assessment of the level sensitizing potency of any chemicals in a high-throughput manner, which can eliminate the needs for animal experiments, potentially saving money and time.Type: ApplicationFiled: November 18, 2011Publication date: July 31, 2014Applicant: Rutgers, The State University of New JerseyInventors: Rene S. Schloss, Martin L. Yarmush, Tim Maguire, Dave Xu Dong, Serom Lee
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Patent number: 8435787Abstract: Alginate polyelectrolyte encapsulation is used for the controlled differentiation of embryonic stem cells. An isolated cell population is provided. The cell population includes a single cell suspension of ES cells encapsulated within an alginate polyelectrolyte microenvironment. The encapsulated ES cells are capable of differentiating within said microenvironment into hepatocyte lineage cells in the absence of embryoid body intermediates or growth factor supplementation.Type: GrantFiled: May 9, 2006Date of Patent: May 7, 2013Assignee: Rutgers, The State University of New JerseyInventors: Tim Maguire, Rene S. Schloss, Martin L. Yarmush
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Publication number: 20120020931Abstract: This application discloses alginate microencapsulation-mediated differentiation of embryonic stem cells and use of the stem cell differentiation method for the development of effective treatment of various diseases and disorders. The microencapsulation of embryonic stem (ES) cells results in decreased cell aggregation and enhanced neural lineage differentiation through incorporating the soluble inducer retinoic acid (RA) into the permeable microcapsule system. This application also discloses a micro-encapsulation system for immobilizing mesenchymal stromal cells (MSCs) while sustaining the molecular communication. Thus, the invention provides the use of encapsulated mesenchymal stromal cells in the cellular transplantation therapies. Moreover, the invention provides methods for delivery of encapsulated MSCs into the central nervous system and therapies derived therefrom, such as, the treatment of spinal cord injury (SCI) and other inflammatory conditions.Type: ApplicationFiled: June 2, 2011Publication date: January 26, 2012Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Martin L. Yarmush, Rene S. Schloss, Martin Grumet, Jeffrey Barminko, Jae Hwan Kim, Tim Maguire, Jean-Pierre Dolle, Lulu Li
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Publication number: 20100184226Abstract: The present invention provides systems and methods for improving the efficiency of a transient gene delivery system to differentiating embryonic stem (ES) cells by serum starving the targeted cells for one to three days prior to transfection. Such a serum starvation surprisingly resulted in increased expression of a constitutively-controlled plasmid from 50.4% to 83.2% of the population and increased expression of a promoter/enhancer controlled plasmid from ˜1.4% to ˜3.7% of the population.Type: ApplicationFiled: September 22, 2009Publication date: July 22, 2010Applicant: Rutgers, the State UniversityInventors: Martin L. Yarmush, Eric J. Wallenstein, Rene S. Schloss