Abstract: A hand-operated tablet pulverizer for crushing solid tablets. A tablet container has a closed end forming a pestle and an open mouth at the other end, the closed end having a peripheral thread. A mortar has an internal thread for complementary engagement with the peripheral thread of the container for moving the pestle into engagement with the mortar upon relative rotation thereof in one direction to crush a tablet interposed therebetween. A plurality of protrusions are formed on at least one of the pestle and mortar projecting toward the other, the protrusions being arranged in a pattern of intersecting lines and columns. The protrusions preferably are generally pyramidal in shape, with the bases of the protrusions coincident with those of adjacent protrusions, whereby the protrusions are equally spaced in the respective lines and columns of the pattern thereof.