Patents by Inventor Reshani Perera

Reshani Perera has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETED NANOBUBBLE THERAPY
    Publication number: 20230092885
    Abstract: A method of inducing cell death in a subject includes administering to the subject a plurality of cell targeted nanobubbles that are internalized by the target cell and insonating nanobubbles internalized into the target cell with ultrasound energy effective to promote inertial cavitation of the internalized nanobubbles and apoptosis and/or necrosis of the target cell.
    Type: Application
    Filed: March 12, 2021
    Publication date: March 23, 2023
    Inventors: AGATA EXNER, JAMES BASILION, AMIN JAFARI SOJARHOOD, AL DELEON, RESHANI PERERA, MICHAEL KOLIOS
  • STABILIZED NANOBUBBLES AND MICROBUBBLES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATION
    Publication number: 20210106699
    Abstract: A composition includes a plurality of stabilized nanobubbles and/or microbubbles. Each nanobubble and/or microbubble has a lipid membrane that defines at least one internal void, which includes at least one gas, the membrane including a plurality of lipids, an edge-activator, which is incorporated between lipids of the membrane and enhances the flexibility of the nanobubbles and/or microbubbles, and a membrane stiffener, which is incorporated on an outer surface of the membrane and enhances the membranes resistance to tearing.
    Type: Application
    Filed: March 29, 2019
    Publication date: April 15, 2021
    Inventors: Agata Exner, Al de Leon, Reshani PERERA, Pinunta Tayacharn
  • STABILIZED CROSSLINKED NANOBUBBLES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
    Publication number: 20190175766
    Abstract: A composition includes a plurality of stabilized crosslinked nanobubbles, each nanobubble having a membrane that defines at least one internal void, which includes at least one gas, the membrane including at least one lipid, at least one nonionic triblock copolymer that is effective to control the size of the nanobubble without compromising in vitro and in vivo echogenicity of the nanobubble, and an interpenetrating crosslinked biodegradable polymer.
    Type: Application
    Filed: June 2, 2017
    Publication date: June 13, 2019
    Inventors: Agata Exner, Reshani Perera, Chris Hernandez
  • TOXICITY ENHANCING COMPOUNDS AND METHODS
    Publication number: 20160000824
    Abstract: A method of treating a tumor or cancer in a subject includes administering to cancer or tumor cells of the subject a radiation sensitizing amount of a poly(ethylene oxide)-poly(propylene oxide) copolymer and administering radiation therapy to the cancer or tumor cells sensitized by the poly(ethylene oxide)-poly(propylene oxide) copolymer.
    Type: Application
    Filed: September 14, 2015
    Publication date: January 7, 2016
    Inventors: Agata Exner, Bryan J. Traughber, Tianyi Krupka, Reshani Perera, David Dremann
  • Toxicity enhancing compounds and methods
    Patent number: 9132149
    Abstract: A method of treating a tumor or cancer in a subject includes administering to cancer or tumor cells of the subject a radiation sensitizing amount of a poly(ethylene oxide)-poly(propylene oxide) copolymer and administering radiation therapy to the cancer or tumor cells sensitized by the poly(ethylene oxide)-poly(propylene oxide) copolymer.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: September 15, 2015
    Assignee: Case Western Reserve University
    Inventors: Agata Exner, Bryan J. Traughber, Tianyi Krupka, Reshani Perera, David Dremann
  • TOXICITY ENHANCING COMPOUNDS AND METHODS
    Publication number: 20120225027
    Abstract: A method of treating a tumor or cancer in a subject includes administering to cancer or tumor cells of the subject a radiation sensitizing amount of a poly(ethylene oxide)-poly(propylene oxide) copolymer and administering radiation therapy to the cancer or tumor cells sensitized by the poly(ethylene oxide)-poly(propylene oxide) copolymer.
    Type: Application
    Filed: March 8, 2012
    Publication date: September 6, 2012
    Inventors: Agata Exner, Bryan J. Traughber, Tianyi Krupka, Reshani Perera, David Dremann