Abstract: Compositions and methods for the treatment of tumors and tumor metastases Compositions and methods are provided to treat or prevent growth of tumors and tumor metastases, in particular of the following malignancies: breast cancer, cancer of the ovaries, cervical cancer, colorectal cancer, cancer of the prostate, lung cancer, cancer of the pancreas, kidney cancer, melanomas, malignant lymphomas and cancers of the central nervous system. The composition comprises a bisphosphonate and a liposome carrier, such as clodronate and a liposome carrier.

Abstract: Amphiphilic nucleoside phosphate analogues of formula I ##STR1## wherein R.sup.1 denotes a hydroxyl or amino group or an acylated or alkylated or polyoxyethylene-substituted amino group, the acyl or alkyl group of which is straight-chained or branched, has 1 to 24 carbon atoms and up to 2 double bonds and may be substituted by an aromatic group;R.sup.2 denotes H, F, a 2-bromo vinyl group or a straight-chained or branched C.sub.1-24 -alkyl group;R.sup.3 and R.sup.4 are identical or different and denote H, hydroxyl, halogen and azido; R.sup.5 denotes a nucleoside group of formula II ##STR2## wherein R.sup.6 denotes a hydroxyl or amino group or an acylated or alkalized amino group, the acyl or alkyl group of which is straight-chained or branched, contains 1 to 24 carbon atoms and up to 2 double bonds and may be substituted by an aromatic group, whilstR.sup.6 and R.sup.1 are different and one of the groups denotes acylamino or alkylamino groups having 12 to 24 carbon atoms,R.sup.1, R.sup.2, R.sup.6 and R.sup.

Abstract: Associates of at least one amphiphilic bilayer-forming substance and a solubilizing agent are formed in an aqueous phase. The bilayer-forming substance itself can be a pharmaceutical substance, or pharmaceutical substances and/or pharmaceutical auxiliaries may be added. The equilibrium conditions for the molar ratio of bilayer-forming substance to solubilizing agent in the associates are then changed in the aqueous phase containing the associates, in order to remove solubilizing agent from the associates, so that the associates combine to form liposomes. In particular, the solubilizing agent concentration in the aqueous phase is reduced, for example by dilution with additional aqueous phase. The change is effected at a rate which is sufficiently high for formation of liposomes having a predefined number of double layers. Furthermore, the rate of change in the aqueous phase is kept virtually constant with respect to location and time. The liposomes thereby achieve a predefined, virtually homogeneous size.

Abstract: A process for producing bilayer vesicles from a colloidal solution comprising mixed micelles of a bilayer-forming substance and a detergent, comprises removing the detergent from the micelle-containing colloidal solution by means of flow-through dialysis whereby the colloidal solution is dialyzed against a dialysis liquid in a chamber whose walls are at least partially formed by a semi-permeable membrane, wherein the dialysis liquid is moved along the outer side of the semi-permeable membrane at a velocity such that the detergent concentration in the dialysis liquid, on at least 90% of the active surface of the membrane, is at most 10% of the detergent concentration in the micelle solution in contact with the other side of the membrane, and wherein a homogeneous detergent concentration is maintained in the micelle solution by the movement of the latter.