Patents by Inventor Ricardo M. Biondi

Ricardo M. Biondi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Allosteric protein kinase modulators
    Patent number: 8912186
    Abstract: The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: December 16, 2014
    Assignee: Universitaet des Saarlandes
    Inventors: Matthias Engel, Wolfgang Fröhner, Adriane Stroba, Ricardo M. Biondi
  • CHIMERIC PDK1 KINASES
    Publication number: 20140017701
    Abstract: The invention provides chimeric 3-phosphoinositide-dependent protein kinase 1 (PDK1), the PIF-binding pocket of which has mutations to mimic a second protein kinase, its production and use. The invention further provides a method for screening for compounds interacting with the PIF-pocket of an AGC kinase.
    Type: Application
    Filed: February 24, 2012
    Publication date: January 16, 2014
    Inventors: Ricardo M. Biondi, Laura A. L. Lopez Garcia, Jörg O. Schulze
  • ALLOSTERIC PROTEIN KINASE MODULATORS
    Publication number: 20120046307
    Abstract: The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.
    Type: Application
    Filed: October 16, 2009
    Publication date: February 23, 2012
    Applicant: UNIVERSITAET DES SAARLANDES
    Inventors: Matthias Engel, Wolfgang Fröhner, Adriane Stroba, Ricardo M. Biondi
  • HIGH RESOLUTION COMPLEX STRUCTURE AND ALLOSTERIC EFFECTS OF LOW MOLECULAR WEIGHT ACTIVATORS ON THE PROTEIN KINASE PDK1
    Publication number: 20120003668
    Abstract: The present invention provides a mutant form of a protein kinase its production and its use for identifying compounds that bind to the PIF-binding pocket allosteric site of the protein kinase.
    Type: Application
    Filed: October 19, 2009
    Publication date: January 5, 2012
    Applicant: UNIVERSITAET DES SAARLANDES
    Inventors: Valerie Hindie, Ricardo M. Biondi
  • METHOD OF MODULATION OF PROTEIN PHOSPHORYLATION-DEPENDENT CONFORMATIONAL TRANSITIONS WITH LOW MOLECULAR WEIGHT COMPOUNDS
    Publication number: 20110152166
    Abstract: The present patent application discloses a method of identifying or validating a compound that modulates the phosphorylation-dependent activity of a target protein or protein complex, where the target protein or protein complex activity is regulated by phosphorylation, as well as the use of identified compounds for the production of a pharmaceutical preparation especially for the treatment of cancer, insulin resistance and diabetes.
    Type: Application
    Filed: August 20, 2007
    Publication date: June 23, 2011
    Inventors: Ricardo M. Biondi, Mathias Engel, Frodin Morten