Patents by Inventor Ricaredo Matanguihan

Ricaredo Matanguihan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FORMULATIONS AND METHODS FOR INCREASED RECOMBINANT PROTEIN PRODUCTION
    Publication number: 20180010090
    Abstract: Formulations and methods to increase the production of recombinant proteins, and other aspects, are disclosed. The formulations and methods relate to increasing mannose or calcium concentration, or both, in a cell culture medium formulation for culturing cells that express recombinant proteins. In some embodiments, a mammalian cell culture medium formulation is provided that has at least one of mannose at about 3.5 g/L or more and calcium in a range from about 1.5 mM to about 9.5 mM. Numerous other aspects and/or embodiments are provided.
    Type: Application
    Filed: September 8, 2017
    Publication date: January 11, 2018
    Inventors: Yuval SHIMONI, Volker MÖHRLE, Venkatesh SRINIVASAN, Ricaredo MATANGUIHAN
  • FORMULATIONS AND METHODS FOR INCREASED RECOMBINANT PROTEIN PRODUCTION
    Publication number: 20160002592
    Abstract: Formulations and methods to increase the production of recombinant proteins, and other aspects, are disclosed. The formulations and methods relate to increasing mannose or calcium concentration, or both, in a cell culture medium formulation for culturing cells that express recombinant proteins. In some embodiments, a mammalian cell culture medium formulation is provided that has at least one of mannose at about 3.5 g/L or more and calcium in a range from about 1.5 mM to about 9.5 mM. Numerous other aspects and/or embodiments are provided.
    Type: Application
    Filed: February 25, 2014
    Publication date: January 7, 2016
    Inventors: Yuval Shimoni, Volker Moehrle, Venkatesh Srinivasan, Ricaredo Matanguihan
  • Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration
    Patent number: 6338964
    Abstract: A cell culture medium which is low in dissolved carbon dioxide is disclosed. The medium contains less than about 1 g/L added sodium bicarbonate and includes an organic buffer and a metal complexing agent. The medium is preferably essentially free of added sodium bicarbonate. Methods of use of the medium in culturing mammalian cells, particularly cells engineered to produce recombinant factor VIII, are also disclosed.
    Type: Grant
    Filed: May 7, 1999
    Date of Patent: January 15, 2002
    Assignee: Bayer Corporation
    Inventors: Ricaredo Matanguihan, Eva Sajan, Konstantin Konstantinov, Michael Zachariou, Charles Olson