Patents by Inventor Riccardo Motterle

Riccardo Motterle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enzymatic process for the preparation of testosterone and esters thereof
    Patent number: 9970042
    Abstract: The present invention relates to a new process for the preparation of testosterone by means of enzymatic hydrolysis of testosterone esters.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: May 15, 2018
    Assignee: F.I.S.-FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Alfredo Paio, Stefano Fogal, Riccardo Motterle
  • Convenient process for the preparation of statins
    Patent number: 9932361
    Abstract: Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.
    Type: Grant
    Filed: March 8, 2016
    Date of Patent: April 3, 2018
    Inventors: Ottorino De Lucchi, Stefano Tartaggia, Clark Ferrari, Marco Galvagni, Marta Pontini, Stefano Fogal, Riccardo Motterle, Rosa Maria Moreno, Alex Comely
  • NEW ENZYMATIC PROCESS FOR THE PREPARATION OF TESTOSTERONE AND ESTERS THEREOF
    Publication number: 20170029863
    Abstract: The present invention relates to a new process for the preparation of testosterone by means of enzymatic hydrolysis of testosterone esters.
    Type: Application
    Filed: July 11, 2016
    Publication date: February 2, 2017
    Inventors: Alfredo Paio, Stefano Fogal, Riccardo Motterle
  • CONVENIENT PROCESS FOR THE PREPARATION OF STATINS
    Publication number: 20160200744
    Abstract: Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.
    Type: Application
    Filed: March 8, 2016
    Publication date: July 14, 2016
    Inventors: Ottorino DE LUCCHI, Stefano TARTAGGIA, Clark FERRARI, Marco GALVAGNI, Marta PONTINI, Stefano FOGAL, Riccardo MOTTERLE, Rosa Maria MORENO, Alex COMELY
  • Convenient process for the preparation of statins
    Patent number: 9315470
    Abstract: Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: April 19, 2016
    Assignee: F.I.S.—Fabbrica Italiana Sintetiei S.p.A.
    Inventors: Ottorino De Lucchi, Stefano Tartaggia, Clark Ferrari, Marco Galvagni, Marta Pontini, Stefano Fogal, Riccardo Motterle, Rosa Maria Moreno, Alex Comely
  • Convenient Process for the Preparation of Statins
    Publication number: 20150344439
    Abstract: Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.
    Type: Application
    Filed: February 11, 2014
    Publication date: December 3, 2015
    Inventors: Ottorino DE LUCCHI, Stefano TARTAGGIA, Clark FERRARI, Marco GALVAGNI, Marta PONTINI, Stefano FOGAL, Riccardo MOTTERLE, Rosa Maria MORENO, Alex COMELY
  • Synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine
    Patent number: 8680276
    Abstract: The present invention relates to the stereoselective synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine, as well as the conversion thereof, to give Moxifloxacin. Particularly, the present invention relates to a method for the synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine of formula (I) comprising: (a) the optical resolution by enzymatic hydrolysis of the intermediate dialkyl-1-alkylcarbonylpiperidine-2,3-dicarboxylate racemate of formula (II) to give, following isolation, the intermediate dialkyl-(2S,3R)-1-alkylcarbonyl-piperidine-2,3-dicarboxylate of formula (III) in which AIk is a straight or branched C1-C5 alkyl group; (b) the conversion of the intermediate (III) to (4aR,7aS)-1-alkylcarbonylhexahydrofuro[3,4-b]pyridine-5,7-dione of formula (IV) in which AIk has the meanings set forth above; (c) the conversion of the intermediate (IV) to (4aS,7as)-octahydro-1H-pyrrolo[3,4-b]pyridine of formula (I) with an optical purity above 99%.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: March 25, 2014
    Inventors: Riccardo Motterle, Giancarlo Arvotti, Elisabetta Bergantino, Andrea Castellin, Stefano Fogal, Marco Galvagni
  • Process for the preparation of testosterone
    Patent number: 8592178
    Abstract: The present invention relates to an industrial process for the reduction of 4-androstene-3,17-dione in order to obtain testosterone using a particularly stable and selective enzyme produced in a recombinant manner.
    Type: Grant
    Filed: June 15, 2010
    Date of Patent: November 26, 2013
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Stefano Fogal, Elisabetta Bergantino, Riccardo Motterle, Andrea Castellin, Giancarlo Arvotti
  • Process for the preparation of intermediates useful in the synthesis of imatinib
    Patent number: 8334381
    Abstract: It is the object of the present invention a process for the preparation of 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-1,3-benzenediamine and analogues thereof, intermediates useful for the synthesis of Imatinib, or 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: December 18, 2012
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Alessandro Falchi, Ennio Grendele, Riccardo Motterle, Mariano Stivanello
  • Process for the preparation of imatinib and intermediates thereof
    Patent number: 8168787
    Abstract: A process for the preparation of 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-1,3-benzenediamine and analogues thereof, intermediates useful for the synthesis of Imatinib, or 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: May 1, 2012
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Alessandro Falchi, Ennio Grendele, Riccardo Motterle, Mariano Stivanello
  • Process for the preparation of ?-alkoxycarbonyllysines and their analogues
    Patent number: 8026372
    Abstract: A process for the preparation of ?-alkoxycarbonylamino-?-aminoacids and ?,? orthogonally diprotected diaminoacids from ?,?-diaminoacids using 1-alkoxycarbonylbenzotriazoles as protecting agents is disclosed. In an alternative embodiment, carbamoylating agents in the presence of benzotriazoles are used instead of 1-alkoxycarbonylbenzotriazoles. This reaction is preferably applied to the preparation of ?-alkoxycarbonyllysines from lysine. A process for the preparation of t-butoxycarbonylbenzotriazoles and novel complexes of ?-alkoxycarbonylamino-?-aminoacids with benzotriazoles are also disclosed.
    Type: Grant
    Filed: August 4, 2006
    Date of Patent: September 27, 2011
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Siro Serafini, Riccardo Motterle, Elena Brasola
  • PROCESS FOR THE PREPARATION OF TESTOSTERONE
    Publication number: 20110207172
    Abstract: The present invention relates to an industrial process for the reduction of 4-androstene-3,17-dione in order to obtain testosterone using a particularly stable and selective enzyme produced in a recombinant manner.
    Type: Application
    Filed: June 15, 2010
    Publication date: August 25, 2011
    Inventors: Stefano Fogal, Elisabetta Bergantino, Riccardo Motterle, Andrea Castellin, Giancarlo Arvotti
  • SYNTHESIS OF (4aS,7aS)-OCTAHYDRO-1H-PYRROLO[3,4-b]PYRIDINE
    Publication number: 20110137036
    Abstract: The present invention relates to the stereoselective synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine, as well as the conversion thereof, to give Moxifloxacin. Particularly, the present invention relates to a method for the synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine of formula (I) comprising: (a) the optical resolution by enzymatic hydrolysis of the intermediate dialkyl-1-alkylcarbonylpiperidine-2,3-dicarboxylate racemate of formula (II) to give, following isolation, the intermediate dialkyl-(2S,3R)-1-alkylcarbonyl-piperidine-2,3-dicarboxylate of formula (III) in which AIk is a straight or branched C1-C5 alkyl group; (b) the conversion of the intermediate (III) to (4aR,7aS)-1-alkylcarbonylhexahydrofuro[3,4-b]pyridine-5,7-dione of formula (IV) in which AIk has the meanings set forth above; (c) the conversion of the intermediate (IV) to (4aS,7as)-octahydro-1H-pyrrolo[3,4-b]pyridine of formula (I) with an optical purity above 99%.
    Type: Application
    Filed: March 4, 2010
    Publication date: June 9, 2011
    Inventors: Riccardo Motterle, Giancarlo Arvotti, Elisabetta Bergantino, Andrea Castellin, Stefano Fogal, Marco Galvagni
  • PROCESS FOR THE PREPARATION OF IMATINIB AND INTERMEDIATES THEREOF
    Publication number: 20100234598
    Abstract: It is the object of the present invention a process for the preparation of 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-1,3-benzenediamine and analogues thereof, intermediates useful for the synthesis of Imatinib, or 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide.
    Type: Application
    Filed: May 20, 2010
    Publication date: September 16, 2010
    Inventors: Alessandro Falchi, Ennio Grendele, Riccardo Motterle, Mariano Stivanello
  • PROCESS FOR THE PREPARATION OF IMATINIB AND INTERMEDIATES THEREOF
    Publication number: 20100076189
    Abstract: It is the object of the present invention a process for the preparation of 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-1,3-benzenediamine and analogues thereof, intermediates useful for the synthesis of Imatinib, or 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide.
    Type: Application
    Filed: November 15, 2007
    Publication date: March 25, 2010
    Inventors: Alessandro Falchi, Ennio Grendele, Riccardo Motterle, Mariano Stivanello
  • PROCESS FOR THE PREPARATION OF EPSILON -ALKOXYCARBONYLLYSINES AND THEIR ANALOGUES
    Publication number: 20090312557
    Abstract: A process for the preparation of ?-alkoxycarbonylamino-?-aminoacids and ?,? orthogonally diprotected diaminoacids from ?,?-diaminoacids using 1-alkoxycarbonylbenzotriazoles as protecting agents is disclosed. In an alternative embodiment, carbamoylating agents in the presence of benzotriazoles are used instead of 1-alkoxycarbonylbenzotriazoles. This reaction is preferably applied to the preparation of ?-alkoxycarbonyllysines from lysine. A process for the preparation of t-butoxycarbonylbenzotriazoles and novel complexes of ?-alkoxycarbonylamino-?-aminoacids with benzotriazoles are also disclosed.
    Type: Application
    Filed: August 4, 2006
    Publication date: December 17, 2009
    Inventors: Siro Serafini, Riccardo Motterle, Elena Brasola
  • Resolution of 3-amino alkylnitriles
    Patent number: 7026345
    Abstract: The present invention relates to chiral N-acetyl-alpha-amino acid salts of optically active ?-amino alkylnitriles, and also to a process for preparing optically active ?-amino alkylnitriles by resolving racemic ?-amino alkylnitriles using chiral N-acetyl-alpha-amino acids as resolving agent.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: April 11, 2006
    Assignee: Pfizer Inc.
    Inventors: Juan Colberg, Samuela Zambelli Franz, Riccardo Motterle, Mariano Stivanello
  • Resolution of 3-amino alkylnitriles
    Publication number: 20050107453
    Abstract: The present invention relates to chiral N-acetyl-alpha-amino acid salts of optically active ?-amino alkylnitriles, and also to a process for preparing optically active ?-amino alkylnitriles by resolving racemic ?-amino alkylnitriles using chiral N-acetyl-alpha-amino acids as resolving agent.
    Type: Application
    Filed: September 17, 2004
    Publication date: May 19, 2005
    Inventors: Juan Colberg, Samuela Franz, Riccardo Motterle, Mariano Stivanello