Abstract: A musculoskeletal stabilization system adapted to stabilize spine and SI joint structures. The musculoskeletal stabilization system includes a spine structure stabilization sub-system and a pelvic structure stabilization sub-system. The pelvic structure stabilization sub-system comprising two multi-function prostheses that are adapted to be delivered to and inserted into SI joints of a subject via a posterior trajectory. The multi-function joint prostheses are further adapted to stabilize respective SI joints and cooperate with the spine stabilization sub-system to also stabilize the subject's spine jointly.

Abstract: A real-time messaging system platform receives from, a communication application installed on a first user communication device, a first user identifier, an indication that a messaging service message composed by the first user is being directed to a first destination associated with a second user, and an identification of data present in the messaging service message. The identification of the data and a message transmission history of the first user is used to enable selection of a message of a first entity. The selected message of the first entity is caused to be displayed by the communication application within a message framework that frames the first user messaging service message. The first entity message is caused to be included in the messaging service message transmitted to the second user device, wherein the first entity is not provided with access to the identity of the first user or the second user.

Abstract: An ejector device for ejecting droplets of fluid onto a surface includes an ejector mechanism attached to a fluid reservoir through a fluid loading plate that is configured to pierce the reservoir and channel the fluid to a rear surface of the ejector mechanism by capillary action. The ejector mechanism may have a centro-symmetric configuration with a lead free piezo actuator and may be covered by an auto-closing cover.

Abstract: Systems are described for conducting minimally invasive medical interventions utilizing instruments and assemblies thereof to stabilize and/or fixate a dysfunctional sacroiliac (SI) joint. The systems include a drill guide adapted to create a pilot SI joint opening in the dysfunctional SI joint through an incision comprising a length no greater than 3.0 cm; portions of the pilot SI joint opening being disposed in the sacrum and ilium bone structures. The drill guide includes a tri-mode fixation system adapted to position and stabilize the drill guide during creation of the pilot SI joint opening in the dysfunctional SI joint and delivery of the SI joint prosthesis therein. The systems also include a SI joint prosthesis configured to be inserted into the pilot SI joint opening of the dysfunctional SI joint, and a prosthesis deployment assembly configured to engage the SI joint prosthesis and advance the SI joint prosthesis into the dysfunctional SI joint.

Abstract: Systems are described for conducting minimally invasive medical interventions utilizing instruments and assemblies thereof to stabilize and/or fixate a dysfunctional sacroiliac (SI) joint. The systems include a drill guide adapted to create a pilot SI joint opening in the dysfunctional SI joint through an incision comprising a length no greater than 3.0 cm; portions of the pilot SI joint opening being disposed in the sacrum and ilium bone structures. The drill guide includes a tri-mode fixation system adapted to position and stabilize the drill guide during creation of the pilot SI joint opening in the dysfunctional SI joint and delivery of the SI joint prosthesis therein. The systems also include a SI joint prosthesis configured to be inserted into the pilot SI joint opening of the dysfunctional SI joint, and a prosthesis deployment assembly configured to engage the SI joint prosthesis and advance the SI joint prosthesis into the dysfunctional SI joint.

Abstract: Methods are described for conducting minimally invasive medical interventions utilizing instruments and assemblies thereof to stabilize and/or fixate a dysfunctional sacroiliac (SI) joint. The methods include the initial steps of providing a drill guide assembly adapted to create a pilot opening in the dysfunctional SI joint, a prosthesis configured to be inserted into the pilot opening created by the drill guide assembly and a prosthesis deployment assembly adapted to engage and advance the prosthesis into the pilot opening in the dysfunctional SI joint. The drill guide assembly includes a drill guide having a prosthesis access opening therethrough; the opening having a configuration that corresponds to the shape of the prosthesis.

Abstract: Methods are described for conducting minimally invasive medical interventions utilizing instruments and assemblies thereof to stabilize and/or fixate a dysfunctional sacroiliac (SI) joint. In one embodiment, a drill assembly is advanced from a posterior approach into the SI joint to create a pilot SI joint opening; portions of which being disposed in the sacrum and ilium bone structures. After the pilot SI joint opening is created, a SI joint prosthesis is inserted into the pilot SI joint opening, wherein the SI joint prosthesis is positioned in the dysfunctional SI joint at a distance of at least 3.0 mm away from the SI joint dorsal recess.

Abstract: Some systems compress data utilized by a user mode software without the user mode software being aware of any compression taking place. To maintain that illusion, such systems prevent user mode software from being aware of and/or accessing the underlying compressed states of the data. While such an approach protects proprietary compression techniques used in such systems from being deciphered, such restrictions limit the ability of user mode software to use the underlying compressed forms of the data in new ways. Disclosed herein are various techniques for allowing user-mode software to access the underlying compressed states of data either directly or indirectly. Such techniques can be used, for example, to allow various user-mode software on a single system or on multiple systems to exchange data in the underlying compression format of the system(s) even when the user mode software is unable to decipher the compression format.

Abstract: An ejector device for ejecting droplets of fluid onto a surface includes an ejector mechanism attached to a fluid reservoir through a fluid loading plate that is configured to pierce the reservoir and channel the fluid to a rear surface of the ejector mechanism by capillary action. The ejector mechanism may have a centro-symmetric configuration with a lead free piezo actuator and may be covered by an auto-closing cover.

Abstract: The present invention relates to a compound of formula (I), or one of its pharmaceutically acceptable salts: (I) wherein R1, R2 and —X—Y— have specific definitions. It also relates to the use of such a compound in therapy; and to a process for preparing it.

Abstract: The present disclosure relates to ejector mechanisms and devices for generating a directed stream of droplets, as well as improved methods for delivering an ejected stream of droplets to a target. The device and methods may be useful for the delivery of fluid for ophthalmic, topical, oral, nasal, or pulmonary use, more particularly, for use in the delivery of ophthalmic fluid to the eye. Certain aspects of the disclosure relate to devices and methods for the delivery of a therapeutically effective low dosage volume medicament composition to a target, e.g., by controlling charge, droplet size and/or droplet deposit parameters of the medicament composition.

Abstract: A set of hinges (1) that allow a user to open and close a set of removable rigid rooftop panels (5, 6) for a vehicle having a hardtop cover, such as a Jeep or sport utility vehicle, without being required to fully remove and store the rigid roof panels. The hinges may be locked in an open position using one or more hasps (24) integrated into the hinges.

Abstract: Disclosed herein are improved overlapping waterproof seams and methods of producing the same.

Abstract: A method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use and a device for droplet ejection includes a fluid delivery system capable of delivering a defined volume of the fluid in the form of droplets having properties that afford adequate and repeatable high percentage deposition upon application. The method and device include a housing, a reservoir disposed within the housing for receiving a volume of fluid, an ejector mechanism configured to eject a stream of droplets having an average ejected droplet diameter greater than 15 microns, the stream of droplets having low entrained airflow such that the stream of droplets deposit on the eye of the subject during use.

Abstract: The disclosure relates to medical databases, remote monitoring, diagnosis and treatment systems and methods. In one particular embodiment, a system for remote monitoring, diagnosis, or treatment of eye conditions, disorders and diseases is provided. This method generally includes administering a stream of droplets to the eye of a subject from an ejector device, and storing data related to the administration in a memory of the ejector device. The data may then be monitored and analyzed.

Abstract: Disclosed are systems and methods for network configuration management systems and methods. In some embodiments, the discloses systems and methods may involve receiving data from one or more nodes within a particular network. The data may include, for example, topology, telemetry, geographical, and other data relating to the nodes, the network, and/or the functionality of the nodes or network. Once received, such data may be cleaned and processing may be performed on the data. Such processing may involve clustering the data into groups based on various parameters and performing forecasting on the data to determine future usage rates and capacity information, for example. The clustering and forecasting results may be fed to a rules engine and/or an optimization engine, which may then determine appropriate actions to take on the network (e.g., changes to various nodes in terms of technology and/or number of nodes).

Abstract: A hinge system for a vehicle hardtop having a system with hinges (1) that allow a user to open and close a set of removable rigid rooftop panels (5, 6) for a Jeep or other sport utility vehicle without being required to fully remove and store the rigid roof panels. The hinges may be capable of supporting a partially opened position to prevent the panels from falling and slamming shut while opening.

Abstract: Some systems compress data utilized by a user mode software without the user mode software being aware of any compression taking place. To maintain that illusion, such systems prevent user mode software from being aware of and/or accessing the underlying compressed states of the data. While such an approach protects proprietary compression techniques used in such systems from being deciphered, such restrictions limit the ability of user mode software to use the underlying compressed forms of the data in new ways. Disclosed herein are various techniques for allowing user-mode software to access the underlying compressed states of data either directly or indirectly. Such techniques can be used, for example, to allow various user-mode software on a single system or on multiple systems to exchange data in the underlying compression format of the system(s) even when the user mode software is unable to decipher the compression format.

Abstract: Disclosed herein are articles (e.g., wearable articles, such as gloves and masks) comprising an antimicrobial material, and methods of manufacture thereof. In various embodiments, the antimicrobial material comprises dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium, or a salt thereof. In some embodiments, the antimicrobial article (e.g., a wearable article, such as a glove or mask) may have antiviral properties against coronavirus, such as SARS-CoV-2.