Patents by Inventor Richard A. Gatti

Richard A. Gatti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Premature-termination-codons readthrough compounds
    Patent number: 9598395
    Abstract: Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 21, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Richard A. Gatti, Liutao Du, Hailiang Hu, Robert Damoiseaux, Michael E. Jung, Jin-Mo Ku, Gladys Completo
  • Premature-termination-codons readthrough compounds
    Patent number: 9255088
    Abstract: Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: February 9, 2016
    Assignee: The Regents of the University of California
    Inventors: Richard Gatti, Liutao Du, Robert Damoiseaux, Chih-Hung Lai, Michael Jung, Jin-Mo Ku, Carmen Bertoni
  • PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS
    Publication number: 20150051251
    Abstract: Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.
    Type: Application
    Filed: March 15, 2013
    Publication date: February 19, 2015
    Applicant: The Regents of the University of California
    Inventors: Richard A. Gatti, Liutao Du, Hailiang Hu, Robert Damoiseaux, Michael E. Jung, Jin-Mo Ku, Gladys Completo
  • PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS
    Publication number: 20130274283
    Abstract: Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.
    Type: Application
    Filed: February 11, 2013
    Publication date: October 17, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Richard A. GATTI, Liutao DU, Robert DAMOISEAUX, Chih-Hung LAI, Michael JUNG, Jin-Mo KU, Carmen BERTONI
  • RAPID ASSAY FOR DETECTING ATAXIA-TELANGIECTASIA HOMOZYGOTES AND HETEROZYGOTES
    Publication number: 20110020829
    Abstract: The present disclosure relates to methods for performing an assay to identify ataxia-telangiectasia homozygotes or heterozygotes. Some embodiments include the use of a rapid flow cytometry-based ataxiatelangiectasia (ATM) kinase assay that measures ATM-dependent phosphorylation of SMC1 following DNA damage.
    Type: Application
    Filed: March 13, 2009
    Publication date: January 27, 2011
    Applicant: The Regents of the University of California
    Inventors: Richard Gatti, Shareef A. Nahas, Anthony W. Butch
  • Expression and purification of ATM protein using vaccinia virus
    Patent number: 6994975
    Abstract: The present disclosure concerns methods for recombinantly producing functional ataxia-telangiectasia (ATM) protein, methods for isolating recombinant functional ATM protein, and uses of ATM protein. In particular, a method is disclosed for using a vaccinia virus vector to express ATM, and using immunoprecipitation or affinity tagging to isolate recombinant ATM.
    Type: Grant
    Filed: January 8, 2002
    Date of Patent: February 7, 2006
    Assignee: The Regents of the University of California
    Inventors: Richard A. Gatti, Helen H. Chun, David J. Rawlings
  • Methods for detection of ataxia telangiectasia mutations
    Patent number: 6951724
    Abstract: The present invention is directed to a method of screening large, complex, polyexonic eukaryotic genes such as the ATM gene for mutations and polymorphisms by an improved version of single strand conformation polymorphism (SSCP) electrophoresis that allows electrophoresis of two or three amplified segments in a single lane. The present invention also is directed to new mutations and polymorphisms in the ATM gene that are useful in performing more accurate screening of human DNA samples for mutations and in distinguishing mutations from polymorphisms, thereby improving the efficiency of automated screening methods.
    Type: Grant
    Filed: June 17, 2002
    Date of Patent: October 4, 2005
    Assignee: The Regents of the University of California
    Inventor: Richard A. Gatti
  • Method of analyzing ataxia-telangiectasia protein
    Publication number: 20040029198
    Abstract: The present disclosure concerns methods for recombinantly producing functional ataxia-telangiectasia (ATM) protein, methods for isolating recombinant functional ATM protein, and uses of ATM protein including diagnosing a patient for A-T and/or susceptibility to various conditions including cancer, particularly breast cancer, neurological disorders, and heart disease. Specifically, a method is disclosed for determining the amount of ATM protein in a patient's cells, comparing that amount to a reference, and forming a diagnosis.
    Type: Application
    Filed: May 5, 2003
    Publication date: February 12, 2004
    Inventors: Richard A. Gatti, Anthony W. Butch, Helen H. Chun, Xia Sun
  • Expression and purification of ATM protein using vaccinia virus
    Publication number: 20030129651
    Abstract: The present disclosure concerns methods for recombinantly producing functional ataxia-telangiectasia (ATM) protein, methods for isolating recombinant functional ATM protein, and uses of ATM protein. In particular, a method is disclosed for using a vaccinia virus vector to express ATM, and using immunoprecipitation or affinity tagging to isolate recombinant ATM.
    Type: Application
    Filed: January 8, 2002
    Publication date: July 10, 2003
    Inventors: Richard A. Gatti, Helen H. Chun, David J. Rawlings
  • Methods for detection of ataxia telangiectasia mutations
    Publication number: 20030082582
    Abstract: The present invention is directed to a method of screening large, complex, polyexonic eukaryotic genes such as the ATM gene for mutations and polymorphisms by an improved version of single strand conformation polymorphism (SSCP) electrophoresis that allows electrophoresis of two or three amplified segments in a single lane. The present invention also is directed to new mutations and polymorphisms in the ATM gene that are useful in performing more accurate screening of human DNA samples for mutations and in distinguishing mutations from polymorphisms, thereby improving the efficiency of automated screening methods.
    Type: Application
    Filed: June 17, 2002
    Publication date: May 1, 2003
    Applicant: The Regents of the University of California
    Inventor: Richard A. Gatti
  • Modified SSCP method using sequential electrophoresis of multiple nucleic acid segments
    Patent number: 6458536
    Abstract: The present invention is directed to a method of screening large, complex, polyexonic eukaryotic genes such as the ATM gene for mutations and polymorphisms by an improved version of single strand conformation polymorphism (SSCP) electrophoresis that allows electrophoresis of two or three amplified segments in a single lane. The present invention also is directed to new mutations and polymorphisms in the ATM gene that are useful in performing more accurate screening of human DNA samples for mutations and in distinguishing mutations from polymorphisms, thereby improving the efficiency of automated screening methods.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: October 1, 2002
    Assignee: The Regents of the University of California
    Inventor: Richard A. Gatti
  • Ataxia-telangiectasia: mutations in the ATM gene
    Patent number: 5955279
    Abstract: The invention is related to ataxia-telangiectasia, specifically, mutations in the ataxia-telangiectasia mutated gene.
    Type: Grant
    Filed: June 13, 1997
    Date of Patent: September 21, 1999
    Inventors: Richard A. Gatti, Patrick J. Concannon