Abstract: Provided is a method of characterising a polynucleotide using a transmembrane pore, wherein the pore is a double pore comprising a first Csg G pore, or a homologue thereof, and a second CsgG pore, or a homologue thereof.

Abstract: The invention relates to improving the movement of a target polynucleotide with respect to a transmembrane pore when the movement is controlled by a polynucleotide binding protein.

Abstract: Methods for deforming a multilayer web are disclosed. Steps of the method include: supplying a first layer of a precursor web; supplying a second layer of the precursor web onto at least the first area of the first layer; forming a plurality of first features and a plurality of second features in the precursor web. The plurality of first features are apertures formed in a first area of the precursor web, and the plurality of second features are formed in a second area of the precursor web in a positive and/or negative Z-direction. The plurality of first features and the plurality of second features are formed simultaneously.

Abstract: A delivery apparatus can include a handle portion and at least one rotatable drive shaft. The handle portion has an actuation mechanism. The actuation mechanism includes a motor and one or more actuators. The rotatable drive shaft has a proximal end portion and a distal end portion. The proximal end portion is coupled to the motor, and the distal end portion is configured to be releasably coupled to a prosthetic heart valve. The actuation mechanism is configured to control and monitor expansion of the prosthetic heart valve. The handle is configured for actuating the actuation mechanism, tracking a response of native tissue when the prosthetic heart valve is in contact with the native tissue, and stopping expansion of the prosthetic heart valve once a rate of change of expansion of the prosthetic heart valve declines below a threshold.

Abstract: A technique for determining an adaptive quantization parameter offset for a block of encoded video includes obtaining a rate control factor for the quantization parameter, determining a content-based quantization parameter factor for the quantization parameter, determining an adaptive variance based quantization offset based on content-based quantization parameter factors for a frame prior to the current frame, and combining the rate control factor, the content-based quantization parameter factor, and the adaptive offset to generate the quantization parameter.

Abstract: A prosthetic implant includes a circumferentially adjustable sealing collar and a rotatable sealer gear. The sealing collar has a central longitudinal axis. The rotatable sealer gear is coupled to and disposed within the sealing collar and configured to adjust the circumference of the sealing collar. The sealer gear is radially offset relative to the central longitudinal axis of the sealing collar. Rotating the sealer gear in a first direction relative to the sealing collar circumferentially expands the sealing collar. Rotating the sealer gear in a second direction relative to the sealing collar circumferentially contracts the sealing collar.

Abstract: The present invention relates to the treatment of autoimmune and allergic diseases by oromucosal administration of a formulation consisting of an optimized combination of antigen, tolerizing agent and mucoadhesive carrier for each immune disease indication.

Abstract: An electrically powered device is secured to the exterior surface of a handgun-mounted laser sight. The powered device includes a housing with two parallel arms that receive between them the laser sight housing. An plug on the inside surface of one arm enters and engages with a battery cavity in the housing to create a physical interference and connection between the powered device and the laser sight device housing. The plug includes electrical circuit elements to electrically connect the powered device to a battery within the cavity. The powered device is powered by connection with a battery contained in the laser sight device to which it is mounted.

Abstract: A handgun mounted accessory such as a laser sight is combined with a triggerguard mounted flush profile switch to provide high reliability of operation. The switch is designed and located to provide passive user switching in use without separate movement or applied force of the user's hand or fingers.

Abstract: The invention relates to improving the movement of a target polynucleotide with respect to a transmembrane pore when the movement is controlled by a polynucleotide binding protein. The invention also relates to improved transmembrane pores and polynucleotide binding proteins.

Abstract: A magnetic module in a circuit interrupting system is configured to generate a blow-on force that pushes a moving contact toward a stationary contact. The magnetic module includes: a coil conductor having an opening through which a moving stem of the moving contact may move, wherein the coil conductor is electrically connected to the moving stem and a first auxiliary conductor, wherein the coil conductor is configured to allow current to flow from the moving stem to the first auxiliary conductor; a plunger attached to an end of the moving stem; and a first magnetic core shaped to fit around a first section of the coil conductor, wherein the first magnetic core is configured, when current flows through the coil conductor to the first auxiliary conductor, to become magnetized, attract the plunger toward the magnetic core, and cause the moving stem of the moving contact to move toward the stationary contact.

Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

Abstract: Some examples include a fishing lure including a tubular body extending between a trailing end and a leading end, the leading and trailing ends each include a pair of notches radially spaced from one another, and a fishhook coupled to the trailing end.

Abstract: An electrically powered device is secured to the exterior surface of a handgun-mounted laser sight. The powered device includes a housing with two parallel arms that receive between them the laser sight housing. An plug on the inside surface of one arm enters and engages with a battery cavity in the housing to create a physical interference and connection between the powered device and the laser sight device housing. The plug includes electrical circuit elements to electrically connect the powered device to a battery within the cavity. The powered device is powered by connection with a battery contained in the laser sight device to which it is mounted.

Abstract: A method of inspecting an object including locating an object on a machine vision apparatus, attaching a light panel to the object to backlight a region of the object, obtaining an image of the region when backlit by the light panel and identifying a geometric property of the object from the image.

Abstract: Systems and methods of the present disclosure are directed to adjustment of seismic survey boundaries to remove or minimize data gaps, thereby providing optimized seismic interpretation.

Abstract: The present invention relates to the manufacture of a chemical reagent whose principal active constituent comprises hydrated metastable forms of CAH10 and C2AH8 in aqueous suspension, and for use of the reagent within other processes where an aqueous suspension of precipitated calcium aluminate is required. The present invention further relates to the use of one or more particle segregation stages to assist the chemical reaction processes that are involved.

Abstract: A handgun mounted accessory such as a laser sight is combined with a triggerguard mounted flush profile switch to provide high reliability of operation. The switch is designed and located to provide passive user switching in use without separate movement or applied force of the user's hand or fingers.

Abstract: The present invention relates to an improved process for treating high sulphate waters. In particular, the present invention relates to an improved process making use of aluminium compounds in order to precipitate layered double hydroxide compounds and any one or more of metals, sulphate, aluminate and phosphate. The present invention further relates to the use of one or more particle segregation stages, as well as the return of aluminium containing compounds from the particle segregation stage and aluminium compounds from a further reaction stage to an initial reaction stage.

Abstract: The invention relates to improving the movement of a target polynucleotide with respect to a transmembrane pore when the movement is controlled by a polynucleotide binding protein.