Patents by Inventor Richard A. J. Warren

Richard A. J. Warren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6124117
    Abstract: Novel polypeptide compositions and methods for their use are provided comprising fusion proteins in which the polysaccharide binding domain or functional portion thereof of a polysaccharidase is fused to a heterologous protein or is conjugated to a chemical moiety. The compositions can be synthesized or prepared by recombinant DNA technology. The compositions find use as removable labels.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: September 26, 2000
    Assignee: University of British Columbia
    Inventors: Douglas G. Kilburn, Robert C. Miller, Richard A. J. Warren, Neil R. Gilkes
  • Patent number: 5962289
    Abstract: Fusion proteins or conjugates are provided containing an amino acid sequence having a substrate binding region of a polysaccharidase such as cellulase that binds to a .beta.-1,4-glycan matrix such as cellulose. The substrate binding region is essentially without polysaccharidase activity. In the fusion protein, the substrate binding region is fused or chemically linked to a polypeptide such as an enzyme, a hormone, an immunoglobulin or a protein dye. By contacting the fusion protein with a .beta.-1,4-glycan matrix, the substrate binding region binds to the matrix to immobilize the polypeptide on the matrix. The polypeptide or fusion protein can be removed from the matrix with a protease acting on a protease recognition sequence or with a solution having a low ionic strength or high pH. In the conjugate, the substrate binding region is joined such as by covalent bonding to a non-protein chemical moiety such as a dye, chromophore, fluorescor, radionuclide or enzyme co-factor.
    Type: Grant
    Filed: January 24, 1997
    Date of Patent: October 5, 1999
    Assignee: The University of British Columbia
    Inventors: Douglas G. Kilburn, Robert C. Miller, Richard A.J. Warren, Neil R. Gilkes
  • Patent number: 5432085
    Abstract: A cell feeder/harvester assembly including a primary platform with at least one recessed culture vessel holding area whereon two pipet tip racks, one for holding sterile pipet tips and the other rack for collecting used pipet tips, and an array of culture vessels are supported. An X assembly extends transversely across the primary platform and is driven longitudinally thereover, the X assembly having a Y assembly, including a secondary platform, disposed thereon which is adapted to be driven transversely over the X assembly, wherein both the X assembly and the Y assembly move so as to position a Z assembly, which is attached to a top of the secondary platform, over a select pair of culture vessels on opposite sides of the secondary platform. The Z assembly is adapted to service all culture vessels on the primary platform, without the need for manual or individualized directing, by removing waste products and adding necessary chemicals to the individual culture vessels.
    Type: Grant
    Filed: July 23, 1993
    Date of Patent: July 11, 1995
    Inventors: Richard J. Warren, Maher M. Lewis, Kitchener C. Wilson
  • Patent number: 5202247
    Abstract: A fusion protein is prepared containing a polypeptide such as an enzyme and an amino acid sequence having a substrate binding region of a polysaccharidase such as cellulase that has essentially no polysaccharidase activity. By contacting the fusion protein with an affinity matrix containing a substrate such as cellulose for the cellulase substrate binding region, the substrate binding region binds to the affinity matrix to immobilize the polypeptide. The polypeptide can be purified by separating the fusion protein or polypeptide from the affinity matrix. The polypeptide can be separated by cleaving the protein with a Cellulomonas fimi protease.
    Type: Grant
    Filed: October 25, 1990
    Date of Patent: April 13, 1993
    Assignee: University of British Columbia
    Inventors: Douglas G. Kilburn, Robert C. Miller, Richard A. J. Warren, Neil R. Gilkes
  • Patent number: 5137819
    Abstract: A fusion protein is prepared containing a polypeptide such as an enzyme and an amino acid sequence having a substrate binding region of a polysaccharidase such as cellulase that has essentially no polysaccharidase activity. By contacting the fusion protein with an affinity matrix containing a substrate such as cellulose for the cellulase substrate binding region, the substrate binding region binds to the affinity matrix to immobilize the polypeptide. The polypeptide can be purified by separating the fusion protein or polypeptide from the affinity matrix.
    Type: Grant
    Filed: July 8, 1988
    Date of Patent: August 11, 1992
    Assignee: University of British Columbia
    Inventors: Douglas G. Kilburn, Robert C. Miller, Richard A. J. Warren, Neil R. Gilkes
  • Patent number: 4319506
    Abstract: Apparatus for severing continuous lengths of hollow fibers into predetermined, equal lengths for use as chemical vapor dispensers is provided.
    Type: Grant
    Filed: May 30, 1980
    Date of Patent: March 16, 1982
    Assignee: Albany International Corp.
    Inventors: Richard J. Warren, Friedhelm Bilewski
  • Patent number: 4290510
    Abstract: A brake rotor with a ceramic-metallic coating. The ceramic-metallic coating provides a wear resistant surface. The coating generally comprises about 30 to 70% by weight of ceramic particles in about 30 to 70% by weight metallic carrier material compatible with the substrate and carbide.
    Type: Grant
    Filed: December 14, 1978
    Date of Patent: September 22, 1981
    Assignee: Chrysler Corporation
    Inventor: Richard J. Warren