Patents by Inventor Richard A. Jefferson
Richard A. Jefferson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7176006Abstract: Genes encoding microbial ?-glucuronidases and proteins and their uses are provided.Type: GrantFiled: February 12, 2003Date of Patent: February 13, 2007Assignee: CambiaInventors: Richard A. Jefferson, Jorge E. Mayer
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Patent number: 7141719Abstract: Genes encoding microbial ?-glucuronidase and protein that is secreted and its uses are provided.Type: GrantFiled: April 11, 2002Date of Patent: November 28, 2006Assignee: CambiaInventors: Richard A. Jefferson, Rebecca L. Harcourt, Andrzej Kilian, Paul Konrad Keese
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Patent number: 7087420Abstract: Genes encoding microbial?-glucuronidases and proteins and their uses are provided.Type: GrantFiled: March 16, 2000Date of Patent: August 8, 2006Assignee: CambiaInventors: Richard A Jefferson, Jorge E Mayer
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Patent number: 6998229Abstract: Clones containing a sequence encoding a glucuronide repressor are described. The nucleotide and amino acid sequences of a repressor (gusR) are presented. A glucuronide repressor is used to control expression of a transgene, detect glucuronides in a sample, and isolate glucuronides from a sample, among other uses.Type: GrantFiled: July 16, 2002Date of Patent: February 14, 2006Assignee: Monticello Research PTY LimitedInventors: Richard A. Jefferson, Katherine J. Wilson
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Publication number: 20050289672Abstract: This invention relates generally to technologies for the transfer of nucleic acids molecules to eukaryotic cells. In particular non-pathogenic species of bacteria that interact with plant cells are used to transfer nucleic acid sequences. The bacteria for transforming plants usually contain binary vectors, such as a plasmid with a vir region of a Ti plasmid and a plasmid with a T region containing a DNA sequence of interest.Type: ApplicationFiled: September 28, 2004Publication date: December 29, 2005Inventor: Richard Jefferson
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Publication number: 20050289667Abstract: This invention relates generally to technologies for the transfer of nucleic acids molecules to eukaryotic cells. In particular non-pathogenic species of bacteria that interact with plant cells are used to transfer nucleic acid sequences. The bacteria for transforming plants usually contain binary vectors, such as a plasmid with a vir region of a Ti plasmid and a plasmid with a T region containing a DNA sequence of interest.Type: ApplicationFiled: September 28, 2004Publication date: December 29, 2005Inventor: Richard Jefferson
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Publication number: 20030229921Abstract: Genes encoding microbial &bgr;-glucuronidases and proteins and their uses are provided.Type: ApplicationFiled: February 12, 2003Publication date: December 11, 2003Applicant: CAMBIAInventors: Richard A. Jefferson, Jorge E. Mayer
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Patent number: 6641996Abstract: Genes encoding microbial &bgr;-glucuronidases and proteins and their uses are provided.Type: GrantFiled: March 17, 1999Date of Patent: November 4, 2003Assignee: CambiaInventors: Richard A. Jefferson, Jorge E. Mayer
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Patent number: 6637625Abstract: A continuous operation metering valve, based on true volumetric positive displacement technology, uses an innovative dual rack and drive pinion design that enables the valve to dispense from one meter chamber while the other meter chamber is filling. This provides greater dispense cycle rates because it does not require a fill or reload period. With an optional encoder-controlled motor, the inventive metering valve is capable of almost unlimited precision dispensing with “on-the-fly” adjustment capability. The metering valve is easily disassembled and cleaned, using stainless steel wetted path components and Teflon seals for the widest range of chemical compatibility. An integral electronic board, mounted to the side of the valve, may be utilized to control the 4-way directional valve and motor direction (when not using a rotary encoder control).Type: GrantFiled: April 19, 2001Date of Patent: October 28, 2003Assignee: Delaware Capital FormationInventor: Richard Jefferson
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Publication number: 20030157684Abstract: Genes encoding microbial &bgr;-glucuronidase and protein that is secreted and its uses are provided.Type: ApplicationFiled: April 11, 2002Publication date: August 21, 2003Applicant: CAMBIAInventors: Richard A. Jefferson, Rebecca L. Harcourt, Andrzej Kilian, Katherine Joanna Wilson, Paul Konrad Keese
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Publication number: 20030143709Abstract: Clones containing a sequence encoding a glucuronide repressor are described. The nucleotide and amino acid sequences of a repressor (gusR) are presented. A glucuronide repressor is used to control expression of a transgene, detect glucuronides in a sample, and isolate glucuronides from a sample, among other uses.Type: ApplicationFiled: July 16, 2002Publication date: July 31, 2003Applicant: CAMBIAInventors: Richard A. Jefferson, Katherine J. Wilson
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Patent number: 6429292Abstract: Clones containing a sequence encoding a glucuronide repressor are described. The nucleotide and amino acid sequences of a repressor (gusR) are presented. A glucuronide repressor is used to control expression of a transgene, detect glucuronides in a sample, and isolate glucuronides from a sample, among other uses.Type: GrantFiled: September 11, 1998Date of Patent: August 6, 2002Inventors: Richard A. Jefferson, Katherine J. Wilson, Michael Leader
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Patent number: 6391547Abstract: Genes encoding microbial &bgr;-glucuronidase and protein that is secreted and its uses are provided.Type: GrantFiled: September 8, 1998Date of Patent: May 21, 2002Assignee: Center for the Application of Molecular Biology to International AgricultureInventors: Richard A. Jefferson, Rebecca Louise Harcourt, Andrzej Kilian, Katherine Joanna Wilson, Paul Konrad Keese
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Publication number: 20010021774Abstract: Cellobiuronic acid may be prepared by hydrolysis of gellan. The method provides embodiments expressed in terms of amounts of cellobiuronic acid produced, amounts of gellan gum hydrolyzed and amounts of cellobiuronic acid present in fractions of a hydrolysate The method may further include isolation of a separated fraction of the hydrolysate where the separated fraction comprises cellobiuronic acid. A preferred embodiment of the method includes hydrolyzing gellan gum with a protic acid under reaction conditions that convert at least 95 wt.% of the gellan gum to a hydrolysate comprised of cellobiuronic acid and monosaccharides and isolating a separated fraction of the hydrolysate where cellobiuronic acid comprises at least a 95 wt.% of saccharides in the separated fraction.Type: ApplicationFiled: May 23, 2001Publication date: September 13, 2001Inventor: Richard A. Jefferson
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Patent number: 6268493Abstract: Cellobiuronic acid may be prepared by hydrolysis of gellan. The method provides embodiments expressed in terms of amounts of cellobiuronic acid produced, amounts of gellan gum hydrolyzed and amounts of cellobiuronic acid present in fractions of a hydrolysate The method may further include isolation of a separated fraction of the hydrolysate where the separated fraction comprises cellobiuronic acid. A preferred embodiment of the method includes hydrolyzing gellan gum with a protic acid under reaction conditions that convert at least 95 wt. % of the gellan gum to a hydrolysate comprised of cellobiuronic acid and monosaccharides and isolating a separated fraction of the hydrolysate where cellobiuronic acid comprises at least a 95 wt. % of saccharides in the separated fraction.Type: GrantFiled: August 7, 1998Date of Patent: July 31, 2001Assignee: Center for the Application of Molecular Biology to International AgricultureInventor: Richard A. Jefferson
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Patent number: 5879906Abstract: Clones containing a sequence encoding a glucuronide repressor are described. The nucleotide and amino acid sequences of a repressor (gusR) are presented. A glucuronide repressor is used to control expression of a transgene, detect glucuronides in a sample, and isolate glucuronides from a sample, among other uses.Type: GrantFiled: June 25, 1997Date of Patent: March 9, 1999Assignee: Cambia Biosystems LLCInventors: Richard A. Jefferson, Katherine J. Wilson, Michael Leader
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Patent number: 5599670Abstract: The present invention relates to the .beta.-glucuronidase (GUS) gene fusion system, and to the cloning and characterization of the .beta.-glucuronidase and glucuronide permease genes of Escherichia coli. It is based on the surprising discovery that gene fusions comprising the .beta.-glucuronidase gene may be effectively expressed in a wide variety of organisms to produce active .beta.-glucuronidase enzyme. Because of the abundance and availability of useful substrates for .beta.-glucuronidase enzyme, GUS gene fusions may serve as a superior reporter gene system as well as an effective means of altering cellular phenotype. In conjunction with recombinant glucuronide permease, which may be used to render host cells permeable to .beta.-glucuronidase substrates, the GUS gene fusion system offers almost unlimited applications in the fields of plant and animal genetic engineering.Type: GrantFiled: February 21, 1995Date of Patent: February 4, 1997Assignee: Cambia Biosystems. L.L.C.Inventor: Richard A. Jefferson
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Patent number: 5432081Abstract: The present invention relates to the .beta.-glucuronidase (GUS) gene fusion system, and to the cloning and characterization of the .beta.-glucuronidase and glucuronide permease genes of Escherichia coli. It is based on the surprising discovery that gene fusions comprising the .beta.-glucuronidase gene may be effectively expressed in a wide variety of organisms to produce active .beta.-glucuronidase enzyme. Because of the abundance and availability of useful substrates for .beta.-glucuronidase enzyme, GUS gene fusions may serve as a superior reporter gene system as well as an effective means of altering cellular phenotype. In conjunction with recombinant glucuronide permease, which may be used to render host cells permeable to .beta.-glucuronidase substrates, the GUS gene fusion system offers almost unlimited applications in the fields of plant and animal genetic engineering.Type: GrantFiled: October 15, 1993Date of Patent: July 11, 1995Assignee: Cambia Biosystems, L.L.C.Inventor: Richard A. Jefferson
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Patent number: 5268463Abstract: The present invention relates to the .beta.-glucuronidase (GUS) gene fusion system, and to the cloning and characterization of the .beta.-glucuronidase and glucuronide permease genes of Escherichia coli. It is based on the surprising discovery that gene fusions comprising the .beta.-glucuronidase gene may be effectively expressed in a wide variety of organisms to produce active .beta.-glucuronidase enzyme. Because of the abundance and availability of useful substrates for .beta.-glucuronidase enzyme, GUS gene fusions may serve as a superior reporter gene system as well as an effective means of altering cellular phenotype. In conjunction with recombinant glucuronide permease, which may be used to render host cells permeable to .beta.-glucuronidase substrates, the GUS gene fusion system offers almost unlimited applications in the fields of plant and animal genetic engineering.Type: GrantFiled: December 8, 1989Date of Patent: December 7, 1993Inventor: Richard A. Jefferson