Patents by Inventor Richard A. Kaufman

Richard A. Kaufman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5525481
    Abstract: An enzymatic assay assemblage for ethanol determination is provided. A diamino compound acts as a buffer and a trapping agent for a product of the enzymatic reaction. Long stability of the assay composition is achieved.
    Type: Grant
    Filed: May 29, 1992
    Date of Patent: June 11, 1996
    Assignee: Hoffman-La Roche Inc.
    Inventors: Richard A. Kaufman, Henry J. Rosenfeld
  • Patent number: 5524764
    Abstract: A combination absorbent applicator, wipe for teeth and oral applicator comprising a sheath having a closed distal end and an open proximal end for receipt of a fingertip or finger. An abrasive absorbent material pad is on an exterior surface of the sheath adjacent the closed distal end. The abrasive absorbent material pad can be applied to teeth, gums, tongue and lips for cleaning and treatment thereof.
    Type: Grant
    Filed: November 30, 1994
    Date of Patent: June 11, 1996
    Inventors: Richard Kaufman, Salvatore Buda
  • Patent number: 5482866
    Abstract: The present invention provides novel reagent compositions incorporating chlorophosphonazo III and a chelating agent and methods utilizing such compositions for the determination of magnesium and magnesium concurrently with calcium in an analytical sample as well as diagnostic test kits for such determinations.
    Type: Grant
    Filed: July 28, 1994
    Date of Patent: January 9, 1996
    Assignee: Hoffmann-La Roche Inc.
    Inventors: James B. Denton, Diane J. Dixon, Richard A. Kaufman
  • Patent number: 5141854
    Abstract: An enzymatic assay composition for ethanol determination is provided. A compound of the formulaH.sub.2 N--(CH.sub.2).sub.n --CHR--CH.sub.2 --NH.sub.2whereR is H, CH.sub.3, or OH andN is 0-4acts as a buffer and a trapping agent for a product of the enzymatic reaction. Long stability of the assay composition is achieved.
    Type: Grant
    Filed: December 13, 1990
    Date of Patent: August 25, 1992
    Assignee: Hoffman-La Roche, Inc.
    Inventors: Richard A. Kaufman, Henry J. Rosenfeld
  • Patent number: 4826773
    Abstract: A reagent for determining quantitatively the amount of phosphorous in bodily fluids which comprises a surface active agent, a strong acid, ammonium molybdate, a heavy metal chelating compound, and anti-oxidant, and deionized water is described. A method of using such a reagent is also described.
    Type: Grant
    Filed: July 18, 1988
    Date of Patent: May 2, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard A. Kaufman, Henry J. Rosenfeld, Denise Zaunczkowski
  • Patent number: 4800168
    Abstract: A method for measuring chloride ion concentration in a sample of body fluid, e.g., serum or plasma is described in which a sample blank is made in the same cuvette after the test measurement has been made.
    Type: Grant
    Filed: October 17, 1985
    Date of Patent: January 24, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Kaufman, Alex Wesolowski
  • Patent number: 4698315
    Abstract: A method for determining total digoxin levels in a biological fluid sample containing digoxin-protein complex which method comprises disrupting the digoxin-protein complex by treating said sample solution with an effective amount of a dissociation agent selected from one or more members of the group consisting of a C.sub.3 -C.sub.26 saturated or unsaturated fatty acid, a C.sub.2-7 lower alkanol, quinidine and .alpha.-tocopherol so as to release the bound digoxin from serum protein, passing the treated sample solution through a centrifugal ultrafilter so as to selectively pass digoxin containing sample solution through said filter and retaining said serum proteins and determining the digoxin contents in said sample solution in a fluorescence polarization assay. A kit for carrying out the method is provided.
    Type: Grant
    Filed: April 22, 1985
    Date of Patent: October 6, 1987
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bruce C. Farrenkopf, Richard A. Kaufman
  • Patent number: 4599316
    Abstract: An improved photometric method for the determination of inorganic phosphate in fluids is disclosed.The method makes use of two reagents, an acid reagent and an ammonium molybdate reagent. Utilizing these reagents, the method comprises the following steps:(a) forming a first mixture consisting of a sample fluid and acid reagent;(b) measuring the light absorbance of said first mixture;(c) forming a second mixture consisting of said first mixture and ammonium molybdate reagent;(d) measuring the light absorbance of said second mixture;(e) calculating the difference in light absorbance (.DELTA.A sample) between the light absorbances measured for said first and second mixtures; and,(f) determining the concentration of inorganic phosphate in said sample fluid by comparing the difference in light absorbance (.DELTA.A sample) for said sample fluid to the difference in light absorbance (.DELTA.A standard) for a standard fluid having a known concentration of inorganic phosphate, .DELTA.
    Type: Grant
    Filed: December 2, 1983
    Date of Patent: July 8, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Benjamin A. Hahn, Richard A. Kaufman, Alexander F. Wesolowski
  • Patent number: 4451563
    Abstract: This invention relates to diagnostic reagents and a method for increasing the sensitivity of chemical and enzymatic analysis. In particular, it relates to an improved reagent and method wherein the sensitivity of the analysis is improved by the addition of a water-soluble inclusion compound.
    Type: Grant
    Filed: August 28, 1981
    Date of Patent: May 29, 1984
    Inventor: Richard A. Kaufman
  • Patent number: 4112022
    Abstract: Nitrile resins, when coagulated from a latex emulsion with inorganic salts of Groups IIA metal ions and compounded with an acrylic acid derivative such as the acrylate of a polyol, an N-substituted acrylamide or a bisacrylamide, exhibit marked improvement in stability toward thermal discoloration.
    Type: Grant
    Filed: March 31, 1977
    Date of Patent: September 5, 1978
    Assignee: Borg-Warner Corporation
    Inventors: Bruce Arthur Marien, Paul Richard Kaufman
  • Patent number: 4100126
    Abstract: Nitrile resins, when coagulated with a latex emulsion with inorganic salts of Group IIA metal ions and compounded with a half acid salt of maleic acid, exhibit marked improvement in stability toward thermal discoloration.
    Type: Grant
    Filed: April 8, 1977
    Date of Patent: July 11, 1978
    Assignee: Borg-Warner Corporation
    Inventors: Gerald Goldberg, Paul Richard Kaufman