Abstract: A method and a system for providing an extract document from a source document, the source document being a classified document, the method including the steps of: a) providing the source document in a computer readable format, selecting at least one item from the source document, establishing an identifying data set to identify the at least one item that has been selected, validating the at least one item that has been selected, e) providing the extract document in a fixed format by performing an irreversible conversion of the source document, based on the source document and the identifying data set for the at least one item that has been validated.

Abstract: The 2-(2-nitrophenyl)propyloxycarbonyl (NPPOC) group has been introduced as a photolabile amino protecting group for amino acids to be used as building blocks in photolithographic solid-phase peptide synthesis. NPPOC-protected amino acids were found to be cleaved in the presence of UV light about twice as fast as the corresponding o-nitroveratryloxycarbonyl (NVOC)-protected amino acids. The protected amino acids are of particular use in the synthesis of peptide arrays.

Abstract: The present invention is directed to a high throughput method for producing a large number of different antibodies, more specifically organized antibody microarrays. These antibodies and antibody microarrays can be used to rapidly assay protein abundance and identify types of proteins that are expressed in cells and tissues under a variety of conditions, or to compare protein expression profiles of different cells.

Abstract: The present invention features a coating consisting of a functionalized polymeric surface coating comprising reactive entities. These entities could consist of amino-, hydroxyl; epoxy- or other covalently linked in a polymer network of polyurea and polyurethane to provide a surface coating. This functionalized coating is applied to surfaces of a non-woven material composed of fibers. One embodiment of present invention is application to fibers at a level of 0.01 to 1 micromole/cm2 amine without poragens to be utilized for peptide and combinational chemistry synthesis. Furthermore, the coating can be applied to fiber at a high level with a crinkly fiber coating abased on the use of a poragen, thus creating a matrix having a higher loading on higher surface area for synthesis and other applications. These embodiments may be applied to various fields and technologies, e.g., proteomics, genomics, combinatorial chemistry, and chromatography.

Abstract: A new method, solid phase precipitation and extraction (SPPE), is disclosed and is particularly advantageous for purifying mixtures of synthetic peptides directly from a cleavage/deprotection mixture.

Abstract: Apparatus for effecting sequential chemical synthesis of a plurality of products on solid supports. A reactor is provided having a movable rotor section including a plurality of reactor modules each containing a solid support. A top stationary stator is provided having a plurality of reactor inlets and a bottom stator is provided having a plurality of reactor outlets. The rotor is rotatably mounted between the top and bottom stators and its position is controlled to effect reactant flow to one or a plurality of desired reactor modules. Alternatively, the movable rotor section can be replaced with a linear array of reactor modules that can move linearly relative to a linear stationary stator section.

Abstract: A chemically modified membrane is positioned between a first template having a first set of holes and a second set of holes aligned with the first set of holes to define a plurality of exposed portions of the membrane in such as manner as to prevent collapse of pores in the membrane during application of a differential pressure across the membrane.