Abstract: The present disclosure relates to improved methods for detecting nucleic acids using DNA fingerloop stem loop structures, wherein the DNA fingerloop stem loop structures diminish base pairing of a detection probe to a mismatched target nucleic acid. The present disclosure also relates to improved methods for amplifying nucleic acids. Further disclosed are chimeric fingerloop DNAs for use in methods for modulating protein expression levels and/or RNA stability.

Abstract: The present disclosure relates to improved methods for detecting nucleic acids using DNA fingerloop stem loop structures, wherein the DNA fingerloop stem loop structures diminish base pairing of a detection probe to a mismatched target nucleic acid. The present disclosure also relates to improved methods for amplifying nucleic acids. Further disclosed are chimeric fingerloop DNAs for use in methods for modulating protein expression levels and/or RNA stability.

Abstract: The present disclosure relates to improved methods for detecting nucleic acids using DNA fingerloop stem loop structures, wherein the DNA fingerloop stem loop structures diminish base pairing of a detection probe to a mismatched target nucleic acid. The present disclosure also relates to improved methods for amplifying nucleic acids. Further disclosed are chimeric fingerloop DNAs for use in methods for modulating protein expression levels and/or RNA stability.

Abstract: The present disclosure relates to chimeric antisense nucleotides and methods for modulating protein expression levels and/or RNA stability from at least two target mRNAs in a cell simultaneously.

Abstract: A roulette-type game apparatus with a non-traditional style. A non-traditional resilient indicator is introduced in the game from above two independently rotating disks. The indicators are dropped through a delivery tube onto an elevated surface. The indicators bounce, from that surface and strike the enclosure, then finally strike the rotating disks which contain indicia and corresponding pockets. The indicators bounce around until they come to rest in a pocket, resulting in a randomly selected winning numbers, number combos, or progressive number. All bets are placed on a table. The game apparatus would have some similar bets as roulette with additional chances to win such as a dual indicator outcome similar to a two die outcome in craps, including a chance to win a progressive jackpot.