Abstract: This defined basal nutrient medium is very effective in both high and low density culture of a wide variety of cell lines and cell types. The medium may be used for serum-free culture or supplemented with low levels of serum. The medium contains a buffer system formulated for air equilibration.

Abstract: Polymer-coated medical and laboratory devices are disclosed which are characterized by their biocompatibility and resistance to nonspecific protein adsorption. The polyurea-polyurethane coatings of this invention are prepared from high molecular weight isocyanate end-capped prepolymers substantially or exclusively comprised of ethylene oxide units. At least 75%, preferably at least 90%, of the prepolymer units are oxyethylene-based diols or polyols having molecular weights of about 7000-30,000, with essentially all of the hydroxyl groups capped with polyisocyanate prior to formation of the hydrated polymer coating.

Abstract: Apparatus and method for converting coal into useful motor fuels and metallurgical coke using a self-cleaning coal pyrolyzer wherein coal is heated in the absence of air at temperatures greater than 800.degree. F. to remove volatile hydrocarbon gases therefrom. Char remaining after such pyrolyzation is cooled and pulverized and mixed with selected binders at temperatures ranging from 125.degree. to 200.degree. F. to form briquettes. The briquettes are calcined at temperatures ranging from 1800.degree. to 2000.degree. F. to form metallurgical coke. The gaseous hydrocarbons are separated into liquid coal fuels, non-condensable gases and water vapor. The liquid coal fuels are further separated into various motor fuels while the non-condensable gases are used to fuel the coal pyrolyzer.

Abstract: The cell culturing system of the present invention includes a tubular membrane, e.g. hollow fiber, cartridge. Provision is made for the continuous circulation of a nutrient-containing medium through the tube side of the cartridge by pumping the nutrient-containing medium in an endless loop. The cells to be cultured are placed within the cartridge on the shell side where the desired extracellular products are accumulated. Nutrients are assimilated into the cell culture through the semipermeable tubular membranes and waste products are removed by passing through the semipermeable membranes into the recirculating nutrient-containing medium. Within the endless loop are located a circulating pump, an oxygenator and a pH probe. The system additionally includes a variable delivery feed pump for continuously injecting fresh nutrient-containing solution into the loop, which feed pump is operated at a rate responsive to the measured pH.

Abstract: A class of modified hydrophilic prepolymers and polymers is disclosed which are characterized by their specific reactivity. Isocyanate-capped oxyethylene-based prepolymers are modified by reacting with a compound having an isocyanate-reactive group which is a sulfhydryl group, an amino group, a hydroxyl group or a carboxyl group, and a non-isocyanate-reactive group, in quantities sufficient to modify at least a portion of the isocyanate groups of the prepolymer. Where said first functional group is an amino group contained in a diamine or polyamine compound or is a carboxyl group, the modifying compound is present in quantities sufficient to modify all or substantially all of the isocyanate groups of the prepolymer.

Abstract: Modified hydrophilic prepolymers and polymers are disclosed wherein the prepolymers and polymers are characterized by cell growth enhancement, and, in some instances, antibody production stimulation. Isocyanate-capped oxyethylene-based prepolymers are modified by reaction with a compound having at least one isocyanate (NCO) reactive group. Preferably, the NCO reactive group is a sulfhydryl group, an amino group or a carboxyl group, in quantities sufficient to modify at least a portion of the isocyanate groups of the prepolymer. The prepolymer and polymer also express a free functional group, preferably an amino, sulfonic acid or a sulfhydryl. When the free functional group is sulfhydryl or sulfonic acid, antibody production stimulation, as well as cell growth enhancement, is observed.

Abstract: An antioxidant useful for stabilizing polyesters having the formula ##STR1## where R.sub.1 is hydrogen or a lower alkyl radical; R.sub.2 is a monovalent radical containing carbon, hydrogen, and oxygen, free of ethylenic or acetylenic unsaturation, and having a molecular weight between about 99-300 and, further, containing two carboxyl groups or their ester forming equivalents; R.sub.3 and R.sub.4 are tertiary alkyl radicals each containing not more than 8 carbon atoms; and x is an integer of from 0-4.