Abstract: Substituted analogs of dextromethorphan (DM) are disclosed, which are shown to have substantial binding affinity at both NMDA and sigma-1 receptors, and which are degraded by human liver enzymes more slowly than dextromethorphan. The analogs are useful as alternatives to dextromethorphan, and can provide the same benefits without requiring co-administration of a cytochrome P-450 enzyme inhibitor.

Abstract: Substituted analogs of dextromethorphan (DM) are disclosed, which are shown to have substantial binding affinity at both NMDA and sigma-1 receptors, and which are degraded by human liver enzymes more slowly than dextromethorphan. The analogs are useful as alternatives to dextromethorphan, and can provide the same benefits without requiring co-administration of a cytochrome P-450 enzyme inhibitor.

Abstract: Systems and methods for a door or window contact sensor are provided. Some systems can include a three-dimensional (3D) microelectromechanical system (MEMS) magnetic sensor, a programmable processor, and executable control software stored on a non-transitory computer readable medium, wherein the 3D MEMS magnetic sensor can measure magnetic parameters of a magnetic field along three axes, and wherein the programmable processor and the executable control software can compare the magnetic parameters to reference values to determine whether the magnetic parameters indicate that a door or a window associated with the 3D MEMS magnetic sensor is open or closed.

Abstract: Systems and methods for a door or window contact sensor are provided. Some systems can include a three-dimensional (3D) microelectromechanical system (MEMS) magnetic sensor, a programmable processor, and executable control software stored on a non-transitory computer readable medium, wherein the 3D MEMS magnetic sensor can measure magnetic parameters of a magnetic field along three axes, and wherein the programmable processor and the executable control software can compare the magnetic parameters to reference values to determine whether the magnetic parameters indicate that a door or a window associated with the 3D MEMS magnetic sensor is open or closed.

Abstract: Systems and methods that address the gap, security, and robustness limitations of known door and window contact systems and methods without increasing the overall cost thereof are provided. Some systems can include an accelerometer and a magnetometer for mounting in or on a first portion of a window or door unit and a microcontroller unit in communication with each of the accelerometer and the magnetometer. The accelerometer can measure acceleration or vibration relative to a second portion of the window or door unit and transmit the measured acceleration or vibration to the microcontroller unit, the magnetometer can measure magnetic field relative to a sensor magnet mounted on or embedded in the second portion of the window or door unit and transmit the measured magnetic field to the microcontroller unit, and the microcontroller unit can use the measured acceleration or vibration and the measured magnetic field to make a security determination.

Abstract: Systems and methods that address the gap, security, and robustness limitations of known door and window contact systems and methods without increasing the overall cost thereof are provided. Some systems can include an accelerometer and a magnetometer for mounting in or on a first portion of a window or door unit, and a microcontroller unit in communication with each of the accelerometer and the magnetometer. The accelerometer can measure acceleration or vibration relative to a second portion of the window or door unit and transmit the measured acceleration or vibration to the microcontroller unit, the magnetometer can measure magnetic field relative to a sensor magnet mounted on or embedded in the second portion of the window or door unit and transmit the measured magnetic field to the microcontroller unit, and the microcontroller unit can use the measured acceleration or vibration and the measured magnetic field to make a security determination.

Abstract: A glassbreak detector includes first and second different audio transducers. The first transducer is omnidirectional. The second transducer is highly directional. Control circuitry processes signals from both of the first and second transducers and determines if a glassbreakage profile is present.

Abstract: A window or door position detector includes an RFID tag attachable to a window or a door and a transceiver. The transceiver emits an activating signal to the tag. The tag, in turn, responds with an identifying RF signal indicative of a predetermined position of the window or the door. The detector includes a transceiver that can communicate with both the tag and a displaced monitoring system control panel.

Abstract: Systems and methods that address the gap, security, and robustness limitations of known door and window contact systems and methods without increasing the overall cost thereof are provided. A system can include a time of flight sensor for mounting in or on a first portion of a window unit or a door unit and a microcontroller unit in communication with the time of flight sensor. The sensor can measure a time for a signal to travel from the sensor to a second portion of the window unit or the door unit and back to the sensor, the sensor can transmit the measured time to the microcontroller unit, and the microcontroller unit can use the measured time to make a security determination.

Abstract: Systems and methods that address the gap, security, and robustness limitations of known door and window contact systems and methods without increasing the overall cost thereof are provided. A system can include a time of fight sensor for mounting in or on a first portion of a window unit or a door unit, and a microcontroller unit in communication with the time of flight sensor. The sensor can measure a time for a signal to travel from the sensor to a second portion of the window unit or the door unit and back to the sensor, the sensor can transmit the measured time to the microcontroller unit, and the microcontroller unit can use the measured time to make a security determination.

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding superoxide dismutase 1, soluble. Methods of using these compounds for modulation of superoxide dismutase 1, soluble expression and for treatment of diseases associated with expression of superoxide dismutase 1, soluble are provided.

Abstract: A window or door position detector includes an RFID tag attachable to the window or door, and a transceiver. The transceiver emits an activating signal to the tag. The tag in turn responds with an identifying RF signal indicative of a predetermined position of the window or door. The detector includes a transceiver which can communicate with both the tag and a displaced monitoring system control panel.

Abstract: An alarm or intrusion monitoring system includes a plurality of detectors which communicate with a displaced control element. Various of the detectors include local storage circuitry wherein detected conditions or events are recorded along with a time indicator. Recorded events and respective times of occurrence can be downloaded to the control element for evaluation. Detected conditions or events can include system conditions, such as faults or detector off-line indicators, as well as various intrusion or environmental-type incidents such as smoke, gas, temperature or fire.

Abstract: A window or door position detector includes an RFID tag attachable to the window or door, and a transceiver. The transceiver emits an activating signal to the tag. The tag in turn responds with an identifying RF signal indicative of a predetermined position of the window or door. The detector includes a transceiver which can communicate with both the tag and a displaced monitoring system control panel.

Abstract: A window or door position detector includes an RFID tag attachable to the window or door, and a transceiver. The transceiver emits an activating signal to the tag. The tag in turn responds with an identifying RF signal indicative of a predetermined position of the window or door. The detector includes a transceiver which can communicate with both the tag and a displaced monitoring system control panel.

Abstract: A window or door position detector includes an RFID tag attachable to the window or door, and a transceiver. The transceiver emits an activating signal to the tag. The tag in turn responds with an identifying RF signal indicative of a predetermined position of the window or door. The detector includes a transceiver which can communicate with both the tag and a displaced monitoring system control panel.

Abstract: An alarm or intrusion monitoring system includes a plurality of detectors which communicate with a displaced control element. Various of the detectors include local storage circuitry wherein detected conditions or events are recorded along with a time indicator. Recorded events and respective times of occurrence can be downloaded to the control element for evaluation. Detected conditions or events can include system conditions, such as faults or detector off-line indicators, as well as various intrusion or environmental-type incidents such as smoke, gas, temperature or fire.

Abstract: A window or door position detector includes an RFID tag attachable to the window or door, and a transceiver. The transceiver emits an activating signal to the tag. The tag in turn responds with an identifying RF signal indicative of a predetermined position of the window or door. The detector includes a transceiver which can communicate with both the tag and a displaced monitoring system control panel.

Abstract: A glassbreak detector or motion detector includes circuitry responsive to an installation process. Data concerning the installation process can be automatically stored in non-volatile memory. The stored data can be retrieved as part of an after-installation review.

Abstract: An acoustic detector comprises an acoustic sensor for receiving an acoustic signal. The acoustic signal selectively comprises a test sound with an encoded pattern indicative of the select mode. A controller is operatively associated with the acoustic sensor for analyzing the received acoustic signal to determine if the encoded pattern is present, changing a mode of operation if the encoded pattern is present, and selectively adjusting the operation of the acoustic detector based upon the received acoustic signal if mode is changed.